Yöresel Organik Ürünlerde Üretim ve Pazarlama Problemleri

Tarımsal ürün üretim sistemlerinde kimyasal girdi kullanılmadan, tamamen doğal girdilerle yapılan ürün yetiştiriciliği organik tarım olarak adlandırılmaktadır. Artan nüfusa paralel olarak ortaya çıkabilecek gıda açığına karşı tarımsal üretimi artırmaya yönelik çeşitli uygulamalar yapılmış ve önemli gelişmeler kaydedilmiştir. Sağlıklı beslenme ve çevre sağlığı açısından oldukça önemli bir uygulama olan organik tarım üretim modeli ülkemizin birçok kırsal kesiminde yerine getirilmesine rağmen tarımsal üretimle uğraşan kişiler bu önemli ürünlerden yeterince kazanç elde edememektedirler. Bu durumun en önemli sebepleri üreticilerin ürettikleri ürün konusunda yeterince bilgi sahibi olmamaları ile ilişkili olarak üretim, işleme ve paketleme yöntemlerinin ürün kalitesi ve sağlığına uygun bir şekilde düzenlenememesi ile pazarlama imkânlarından yeterince faydalanamama gibi durumlardır. Organik tarımsal üretim açısından önemli bir potansiyele sahip olan yöresel ürünlerin uygun yöntemlerle üretilip işlenerek daha sağlıklı şartlarda tüketicilere sunulmalarının sağlanması durumunda kırsal kesimdeki tarımsal ürün yetiştiricilerinin elde edecekleri gelirde artış sağlanabileceği gibi insan ve çevre sağlığına da önemli katkılar sağlanacaktır

Prolonged coagulopathy related to coumarin rodenticide in a young patient: superwarfarin poisoning

Superwarfarins (brodifacoum, difenacoum, bromodialone and chlorphacinone) are anticoagulant rodenticides that were developed in 1970s to overcome resistance to warfarin in rats. A 26-year-old previously healthy man was admitted to the emergency department with epigastric pain, severe upper and lower gastrointestinal haemorrhage, gingival bleeding and melena. The patient stated that he had been healthy with no prior hospital admissions and no personal or family history of bleeding diathesis. The patient, who later admitted attempted suicide, stated that he had taken 400 g rodenticide including brodifacoum orally for five days prior to admission to hospital. He had oral mucosal bleeding, numerous bruises over the arms, legs and abdomen, and an abdominal tenderness, together with melena. Laboratory tests revealed a haemoglobin level of 12.3 g/dl, leucocyte count of 9.1 x 10(9)/l, haematocrit of 28% and platelet count of 280 x 10(9)/l. The prothrombin time (PT) was > 200 s (normal range 10.5-15.2 s) and the activated partial thromboplastin time (aPTT) was 91 s (normal range 20-45 s). The INR (International normalised ratio) was reported to be > 17 (normal range 0.8-1.2). The thrombin time and plasma fibrinogen levels were in the normal range. The results showed the presence of brodifacoum at a concentration of 61 ng/ml, detected by reversed-phase liquid chromatography

Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher incidence in the Turkish, Jewish, Arabic, and Armenian populations. As our understanding of FMF improves, it becomes clearer that we are facing with a more complex picture of FMF with respect to its pathogenesis, penetrance, variant type (gain-of-function vs. loss-of-function), and inheritance. In this study, MEFV gene analysis results and clinical findings of 27,504 patients from 35 universities and institutions in Turkey and Northern Cyprus are combined in an effort to provide a better insight into the genotype-phenotype correlation and how a specific variant contributes to certain clinical findings in FMF patients. Our results may help better understand this complex disease and how the genotype may sometimes contribute to phenotype. Unlike many studies in the literature, our study investigated a broader symptomatic spectrum and the relationship between the genotype and phenotype data. In this sense, we aimed to guide all clinicians and academicians who work in this field to better establish a comprehensive data set for the patients. One of the biggest messages of our study is that lack of uniformity in some clinical and demographic data of participants may become an obstacle in approaching FMF patients and understanding this complex disease