Triangle Counting Rule: An Approach to Forecast the Magnetic Properties of Benzenoid Polycyclic Hydrocarbons

Open-shell benzenoid polycyclic hydrocarbons (BPHs) are promising materials for future quantum applications. However, the search and realization of open-shell BPHs with desired properties is a challenging task due to the gigantic chemical space of BPHs, requiring new strategies for both theoretical understanding and experimental advancement. In this work, by building a structure database of BPHs through graphical enumeration, performing data-driven analysis, and combining tight-binding and mean-field Hubbard calculations, we discovered that the number of the internal vertices of the BPH graphs is closely correlated to their open-shell characters. We further established a series of simple rules, the triangle counting rule (TCR), to predict the magnetic ground state of BPHs. These findings not only provide a database of open-shell BPHs, but also extend the well-known Lieb's theorem and Ovchinnikov's rule and provide a straightforward method for designing open-shell carbon nanostructures. These insights may aid in the exploration of emerging quantum phases and the development of magnetic carbon materials for technology applications.Comment: 6 pages, 4 figure

Role of G-protein coupled receptors in cardiovascular diseases

Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an essential regulating cellular physiology and pathology. Some GPCR antagonists, such as β-blockers, are standard therapy for the treatment of CVDs. In addition, nearly one-third of the drugs used to treat CVDs target GPCRs. All the evidence demonstrates the crucial role of GPCRs in CVDs. Over the past decades, studies on the structure and function of GPCRs have identified many targets for the treatment of CVDs. In this review, we summarize and discuss the role of GPCRs in the function of the cardiovascular system from both vascular and heart perspectives, then analyze the complex ways in which multiple GPCRs exert regulatory functions in vascular and heart diseases. We hope to provide new ideas for the treatment of CVDs and the development of novel drugs

Far-field transient absorption nanoscopy with sub-50 nm optical super-resolution

Nanoscopic imaging or characterizing is the mainstay of the development of advanced materials. Despite great progress in electronic and atomic force microscopies, label-free and far-field characterization of materials with deep sub- wavelength spatial resolution has long been highly desired. Herein, we demonstrate far-field super-resolution transient absorption (TA) imaging of two-dimensional material with a spatial resolution of sub-50 nm. By introducing a donut- shaped blue saturation laser, we effectively suppress the TA transition driven by near-infrared (NIR) pump–probe photons, and push the NIR-TA microscopy to sub-diffraction-limited resolution. Specifically, we demonstrate that our method can image the individual nano-grains in graphene with lateral resolution down to 36 nm. Further, we perform super-resolution TA imaging of nano-wrinkles in monolayer graphene, and the measured results are very consistent with the characterization by an atomic force microscope. This direct far-field optical nanoscopy holds great promise to achieve sub-20 nm spatial resolution and a few tens of femtoseconds temporal resolution upon further improvement and represents a paradigm shift in a broad range of hard and soft nanomaterial characterization

TRPV1 Channel Contributes to the Behavioral Hypersensitivity in a Rat Model of Complex Regional Pain Syndrome Type 1

Complex regional pain syndrome type 1 (CRPS-I) is a debilitating pain condition that significantly affects life quality of patients. It remains a clinically challenging condition and the mechanisms of CRPS-I have not been fully elucidated. Here, we investigated the involvement of TRPV1, a non-selective cation channel important for integrating various painful stimuli, in an animal model of CRPS-I. A rat model of chronic post-ischemia pain (CPIP) was established to mimic CRPS-I. TRPV1 expression was significantly increased in hind paw tissue and small to medium-sized dorsal root ganglion (DRG) neurons of CPIP rats. CPIP rats showed increased TRPV1 current density and capsaicin responding rate in small-sized nociceptive DRG neurons. Local pharmacological blockage of TRPV1 with the specific antagonist AMG9810, at a dosage that does not produce hyperthermia or affect thermal perception or locomotor activity, effectively attenuated thermal and mechanical hypersensitivity in bilateral hind paws of CPIP rats and reduced the hyperexcitability of DRG neurons induced by CPIP. CPIP rats showed bilateral spinal astrocyte and microglia activations, which were significantly attenuated by AMG9810 treatment. These findings identified an important role of TRPV1 in mediating thermal and mechanical hypersensitivity in a CRPS-I animal model and further suggest local pharmacological blocking TRPV1 may represent an effective approach to ameliorate CRPS-I

Accelerated Synthesis and Discovery of Covalent Organic Framework Photocatalysts for Hydrogen Peroxide Production

[Image: see text] A high-throughput sonochemical synthesis and testing strategy was developed to discover covalent organic frameworks (COFs) for photocatalysis. In total, 76 conjugated polymers were synthesized, including 60 crystalline COFs of which 18 were previously unreported. These COFs were then screened for photocatalytic hydrogen peroxide (H(2)O(2)) production using water and oxygen. One of these COFs, sonoCOF-F2, was found to be an excellent photocatalyst for photocatalytic H(2)O(2) production even in the absence of sacrificial donors. However, after long-term photocatalytic tests (96 h), the imine sonoCOF-F2 transformed into an amide-linked COF with reduced crystallinity and loss of electronic conjugation, decreasing the photocatalytic activity. When benzyl alcohol was introduced to form a two-phase catalytic system, the photostability of sonoCOF-F2 was greatly enhanced, leading to stable H(2)O(2) production for at least 1 week

Numerical Simulation of the Fractional Dispersion Advection Equations Based on the Lattice Boltzmann Model

The fractional dispersion advection equations (FDAEs) have recently attracted considerable attention due to their extensive application in the fields of science and engineering. For example, it has been shown that the anomalous solute transport behaviour that exists in hydrology can be well explained by introducing FDAEs. Therefore, the study of FDAEs has profound significance for understanding real transport phenomena in nature. Nevertheless, the existing algorithms for the FDAEs are generally intricate and costly. Therefore, exploiting an efficient solution technique has been a concern for scientists. In an effort to overcome this challenge, a promising lattice Boltzmann (LB) model for the FDAEs is presented in this paper. The Riemann–Liouville definition and the Grünwald–Letnikov definition are introduced for the time derivatives. In addition, Chapman–Enskog analysis is applied to recover the FDAEs. To test the validity of the model, three numerical examples are carried out. In addition, a comparative study of the proposed model and the classical implicit finite difference scheme is also conducted. The numerical results show that the model is suitable for simulating FDAEs

Satellite-Based Monitoring on Green-Up Date for Optimizing the Rest-Grazing Period in Xilin Gol Grassland

Ecological degradation has occurred in global grasslands and has impaired their ecosystem services severely, so ecological conservation of grasslands should be focused more on the effectiveness of management measures. The green-up process decides the year-round forage yield and ecological conditions of grasslands. Adopting rest-grazing during the green-up process can guarantee a successful green-up, thus realizing more economic benefits without grassland degradation. Therefore, studies should pay more attention to whether the green-up process is really covered by the rest-grazing period or not. We analyze the spatiotemporal variations and the stability of the annual green-up date in Xilin Gol Grassland from 2000 to 2018 based on MODIS time series images and compare the green-up date with the rest-grazing period to assess the effectiveness of the rest-grazing policy. The results show that the green-up date of Xilin Gol Grassland had advanced 15 days on average because of the increasing trend of both temperature and precipitation during 2000~2018. The green-up date is mostly 120~130 d in the east, about 10 days earlier than the west (130~140 d) and 20 days earlier than in the central areas (140~150 d), also because of the spatial variations of temperature and precipitation. The coefficient of variation (CV) of the green-up date showed a significant negative correlation with precipitation, so the green-up date is more unstable in the arid areas. The rest-grazing period started more than 45 days earlier than the green-up date and failed to cover it in several years, which occurred more frequently in southern counties. The average green-up date appeared after rest-grazing started in over 98% of areas, and the time gap is 15~45 days in 88% of areas, which not only could not avoid grassland degradation effectively but also increased herdsmen’s life burden. This study aims to accurately grasp the temporal and spatial variations of the green-up date in order to provide references for adjusting a more proper rest-grazing period, thus promoting ecological conservation and sustainable development of animal husbandry