Exploring Environmental Heat Injuries in the Pediatric Population

Children are considered a vulnerable population in society. While thermoregulation in children is similar to that of an adult, children are vulnerable to heat-related illness. Student athletes have been found to be particularly vulnerable to heat-related illness for numerous reasons, including intense outdoor play. Football players are perhaps the most at-risk population of student athletes due to the intense physical requirements, outdoor practice during the hottest months of the year, and the extensive protective equipment required. By conducting a literature review on the subject of pediatric heat illness, the purpose of this thesis is to explore evidenced based research and guidelines regarding heat-related illness prevention. This review of literature was conducted through the utilization of the University of Central Florida\u27s online databases using the EBSCOhost platform of: CINAHL Plus with Full Text, Cochrane Database of Systematic Reviews, ERIC, Health Source: Nursing/Academic Edition, MEDLINE, PsycINFO and SPORTDiscus. This thesis is unique because it does not focus on an individual sport; rather, it focuses on pediatric athletes from various disciplines. The prevalence, pathophysiology, prevention, and treatment of heat-related injuries are complex phenomena requiring the attention of law makers, athletic associations, school officials, coaches, athletic trainers, parents, and students

Examining the Relationship Between Mobile Phone Utilization on Self-Directed Online Professional Development Among Early Childhood Practitioners: A Preregistered Study

This study examines Arkansas early childhood practitioners\u27 propensity for self-directed learning when using mobile phones to participate in self-paced online professional development. Further, the activity system model provides context for understanding practitioners\u27 willingness to use technology, like smartphones, to adopt new information when interacting in online learning formats. The problem is that although we must offer professional development to ensure we have competent early childhood practitioners statewide, we are uncertain whether those practitioners have the propensity to use mobile phones to direct their online learning. The purpose of this cross-sectional regression study is to examine the relationship between early childhood practitioners\u27 mobile phone usage and their self-directed learning while considering the moderating influence of technology readiness when participating in asynchronous online professional development. This study aims to go beyond simply looking at the effect of mobile phone use on practitioners\u27 propensity for self-directed learning. It also examines the potential for technology readiness to moderate the relationship between these factors through a multiple linear regression analysis utilizing survey data. The study\u27s implications regarding practitioners\u27 self-directed online learning when using mobile phones may provide insights for professional development stakeholders who govern, develop, and implement early childhood practitioner continuing education and workforce training

Investigating Student Perceptions of the Effectiveness of a First-Year Experience Online Program on Student Retention

This applied dissertation is a mixed-methods study designed to collect student perspectives of an online First-Year Experience (FE) course and to determine the overall value of the FE course. The researcher sought to identify what is the value of the FE course to the students enrolled in this online course. In the study’s survey, students will be asked a series of questions designed to determine the overall value of the FE course. For this study, the online FE course survey addressed the following theme areas: Course Content, Overall Satisfaction, Transfer Perceptions, and the participants are the new incoming students (first-year and transfer status) that were enrolled and have completed the online FE course. The researcher collected demographic data and analyzed Likert-like scale questions from survey responses. The survey contained open-ended questions inviting the students to express their “lived” experiences, having completed the online FE course based on perceived value. The transcribed open-ended questions were sorted into common themes that indicate the students’ perceptions of their “lived” experiences while taking this online FE course. The research that has been undertaken for this study has highlighted how retention rates and first-year student perceptions are essential when implementing an FE course at a university and that further research would be beneficial. The researcher would recommend expanding this survey at multiple universities to diversify the findings of demographical and retention data, as well as the perceptions of first-year students in varied FE course programs

Force‐sensing catheters during pediatric radiofrequency ablation: The FEDERATION Study

Background Based on data from studies of atrial fibrillation ablations, optimal parameters for the TactiCath (TC; St. Jude Medical, Inc) force‐sensing ablation catheter are a contact force of 20 g and a force‐time integral of 400 g·s for the creation of transmural lesions. We aimed to evaluate TC in pediatric and congenital heart disease patients undergoing ablation. Methods and Results Comprehensive chart and case reviews were performed from June 2015 to March 2016. Of the 102 patients undergoing electrophysiology study plus ablation, 58 (57%) underwent ablation initially with a force‐sensing catheter. Patients had an average age of 14 (2.4–23) years and weight of 58 (18–195) kg with 15 patients having abnormal cardiac anatomy. Electrophysiology diagnoses for the + TC group included 30 accessory pathway–mediated tachycardia, 24 atrioventricular nodal reentrant tachycardia, and 7 other. Baseline generator settings included a power of 20 W, temperature of 40°, and 6 cc/min flow during lesion creation with 11 patients (19%) having alterations to parameters. Seventeen patients (30%) converted to an alternate ablation source. A total of 516 lesions were performed using the TC with a median contact force of 6 g, force‐time integral of 149 g·s, and lesion size index of 3.3. Median‐term follow‐up demonstrated 5 (10%) recurrences with no acute or median‐term complications. Conclusions TactiCath can be effectively employed in the treatment of pediatric patients with congenital heart disease with lower forces than previously described in the atrial fibrillation literature. Patients with atrioventricular nodal reentrant tachycardia or atrioventricular reciprocating tachycardia may not require transmural lesions and the TC may provide surrogate markers for success during slow pathway ablation. </jats:sec

Metalloprotein Crystallography: More than a Structure

Metal ions and metallocofactors play important roles in a broad range of biochemical reactions. Accordingly, it has been estimated that as much as 25–50% of the proteome uses transition metal ions to carry out a variety of essential functions. The metal ions incorporated within metalloproteins fulfill functional roles based on chemical properties, the diversity of which arises as transition metals can adopt different redox states and geometries, dictated by the identity of the metal and the protein environment. The coupling of a metal ion with an organic framework in metallocofactors, such as heme and cobalamin, further expands the chemical functionality of metals in biology. The three-dimensional visualization of metal ions and complex metallocofactors within a protein scaffold is often a starting point for enzymology, highlighting the importance of structural characterization of metalloproteins. Metalloprotein crystallography, however, presents a number of implicit challenges including correctly incorporating the relevant metal or metallocofactor, maintaining the proper environment for the protein to be purified and crystallized (including providing anaerobic, cold, or aphotic environments), and being mindful of the possibility of X-ray induced damage to the proteins or incorporated metal ions. Nevertheless, the incorporated metals or metallocofactors also present unique advantages in metalloprotein crystallography. The significant resonance that metals undergo with X-ray photons at wavelengths used for protein crystallography and the rich electronic properties of metals, which provide intense and spectroscopically unique signatures, allow a metalloprotein crystallographer to use anomalous dispersion to determine phases for structure solution and to use simultaneous or parallel spectroscopic techniques on single crystals. These properties, coupled with the improved brightness of beamlines, the ability to tune the wavelength of the X-ray beam, the availability of advanced detectors, and the incorporation of spectroscopic equipment at a number of synchrotron beamlines, have yielded exciting developments in metalloprotein structure determination. Here we will present results on the advantageous uses of metals in metalloprotein crystallography, including using metallocofactors to obtain phasing information, using K-edge X-ray absorption spectroscopy to identify metals coordinated in metalloprotein crystals, and using UV–vis spectroscopy on crystals to probe the enzymatic activity of the crystallized protein.National Institutes of Health (U.S.) (Grant GM069857)National Institutes of Health (U.S.) (Grant F32-GM099257)National Institutes of Health (U.S.) (Grant F32-GM108189

Giant Left Atrial Myxoma Masquerading as Cough-Syncope Syndrome

Left atrial myxomas are the most common type of benign primary cardiac tumor. Patients can present with generalized symptoms, such as fatigue, symptoms from obstruction of the myxoma, or even embolization of the myxoma causing distal thrombosis. We describe a case with several-month duration of syncopal episodes that occurred after coughing and with exertion. Computed tomography of the chest showed a 6.1 cm by 4.5 cm mass in the left atrium, later evaluated with an echocardiogram. Cardiothoracic surgery removed the mass, and it was determined to be an atrial myxoma. It is important for an internist to be able to diagnose an atrial myxoma because of the risks associated with embolization and even sudden death as myxoma can block blood supply from atrium to ventricle

Advertising Aimed Toward Working Women Before and After World War II

Even at the start of the war in Europe in 1939, women workers were only turned to as a last resort, The war in Europe had brought a flood of economic activity to America. Recovering businesses damaged during the Great Depression were once again prosperous, bringing hope to the American public for a bright future. In fact, World War II quickly turned the unemployment problem into one of a labor shortage and rocketed the economy into new heights of production and prosperity. (Hartmann, 2) Business was booming and people were working. Traditional beliefs that men should be the primary or sole breadwinners in the family was especially significant in limiting women\u27s job opportunities as long as unemployed men were still available to fill the labor needs. (Anderson, 24) The resistance to hiring women before all sources of male labor were depleted was encouraged by the War Department itself. A Civil Defense official was quoted as saying give the women something to do to keep their hands busy as we did in the last war--then maybe they won\u27t bother us. (Kessler-Harris, 274) Meaning women were still only expected to volunteer and do housework

Antibody responses to a Cryptosporidium parvum rCP15/60 vaccine

Cryptosporidium parvum is a zoonotic apicomplexa-protozoan pathogen that causes gastroenteritis and diarrhoea in mammals worldwide. The organism is transmitted by ingestion of oocysts, which are shed in faeces, and completes its lifecycle in a single host.^1^ C. parvum is ubiquitous on dairy operations worldwide and is one of the leading causes of diarrhoea in calves on these farms.^2,3^ Here, for the first time, we describe the antibody response in a large group of cows to a recombinant C. parvum oocyst surface protein (rCP15/60) vaccine and the antibody response in calves fed rCP15/60-immune colostrum produced by these vaccinated cows. Results of recent genotype surveys indicate that calves are the only major reservoir for C. parvum infections in humans.^4^ Human C. parvum infections are particularly prevalent and often fatal in neonates in developing countries and to immunocompromised people, such as AIDs patients.^4^ Drug therapy against cryptosporidiosis is limited and not wholly efficacious in either humans or calves^5^, making development of an effective vaccine of paramount importance. To date, there is no commercially available effective vaccine against C. parvum, although passive immunization utilizing different zoite surface (glyco)proteins has showed promise.^6-9^ All cows we vaccinated produced an antibody response to the rCP15/60 vaccine and the magnitude of response correlated strongly with the subsequent level of antibody in their colostrum. All calves fed rCP15/60-immune colostrum showed a dose-dependent absorption of antibody. Our results demonstrate that vaccination of cows with rCP15/60 successfully induces antibodies against CP15/60 in their serum and colostrum and that these antibodies are then well absorbed when fed to neonatal calves. With further research, this C. parvum vaccine may well be a practical method of conferring passive protection to calves against cryptosporidiosis. Furthermore, a specifically targeted immune-colostrum may be valuable in protection and treatment of immunocompromised human patients with cryptosporidiosis