Tra saeculum e mysterium fidei. La chiesa cattolica in regime di lockdown

The consequences of the pandemic on the presence of the Catholic Church. The relation State-Church. The adaptive strategies by the church followers and by the religious institution. The role played by Pope Francis.The Catholicism between visibility and evanescence. The questions asked to the institution and the possible outcomes for the future way of believing

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

La variante C

The pandemic is a watershed between a ‘before’, that was already suffering the fatigues of the crisis of the model of a Church’s religion, and an ‘after’ that cannot simply ‘resume’ spaces and times denied in the months of the most rigid lockdown in which the Government had imposed, and willingly accepted by the hierarchies of Catholic Church, the cancellation of any activity in presence. The pandemic has imposed itself as a total social fact and this characteristic asks for a broader reflection on some issues that have more to do with the presence in society of the Church and not just with a simple resuming of ordinary religious functions and services. There are consequences on the sacramental practice, on the community dimension and on the public relevance of the Italian Catholic Church