610 research outputs found
Mean field and corrections for the Euclidean Minimum Matching problem
Consider the length of the minimum matching of N points in
d-dimensional Euclidean space. Using numerical simulations and the finite size
scaling law , we obtain
precise estimates of for . We then consider
the approximation where distance correlations are neglected. This model is
solvable and gives at an excellent ``random link'' approximation to
. Incorporation of three-link correlations further improves
the accuracy, leading to a relative error of 0.4% at d=2 and 3. Finally, the
large d behavior of this expansion in link correlations is discussed.Comment: source and one figure. Submitted to PR
IL-1 beta and TNF alpha Promote Monocyte Viability through the Induction of GM-CSF Expression by Rheumatoid Arthritis Synovial Fibroblasts
Background. Macrophages and synovial fibroblasts (SF) are two major cells implicated in the pathogenesis of rheumatoid arthritis (RA). SF could be a source of cytokines and growth factors driving macrophages survival and activation. Here, we studied the effect of SF on monocyte viability and phenotype. Methods. SF were isolated from synovial tissue of RA patients and CD14+ cells were isolated from peripheral blood of healthy donors. SF conditioned media were collected after 24 hours of culture with or without stimulation with TNFα or IL-1β. Macrophages polarisation was studied by flow cytometry. Results. Conditioned medium from SF significantly increased monocytes viability by 60% compared to CD14+ cells cultured in medium alone . This effect was enhanced using conditioned media from IL-1β and TNFα stimulated SF. GM-CSF but not M-CSF nor IL34 blocking antibodies was able to significantly decrease monocyte viability by 30% when added to the conditioned media from IL-1β and TNFα stimulated SF . Finally, monocyte cultured in presence of SF conditioned media did not exhibit a specific M1 or M2 phenotype. Conclusion. Overall, rheumatoid arthritis synovial fibroblasts stimulated with proinflammatory cytokines (IL-1β and TNFα) promote monocyte viability via GM-CSF but do not induce a specific macrophage polarization
Performance of ePix10K, a high dynamic range, gain auto-ranging pixel detector for FELs
ePix10K is a hybrid pixel detector developed at SLAC for demanding
free-electron laser (FEL) applications, providing an ultrahigh dynamic range
(245 eV to 88 MeV) through gain auto-ranging. It has three gain modes (high,
medium and low) and two auto-ranging modes (high-to-low and medium-to-low). The
first ePix10K cameras are built around modules consisting of a sensor flip-chip
bonded to 4 ASICs, resulting in 352x384 pixels of 100 m x 100 m each.
We present results from extensive testing of three ePix10K cameras with FEL
beams at LCLS, resulting in a measured noise floor of 245 eV rms, or 67 e
equivalent noise charge (ENC), and a range of 11000 photons at 8 keV. We
demonstrate the linearity of the response in various gain combinations: fixed
high, fixed medium, fixed low, auto-ranging high to low, and auto-ranging
medium-to-low, while maintaining a low noise (well within the counting
statistics), a very low cross-talk, perfect saturation response at fluxes up to
900 times the maximum range, and acquisition rates of up to 480 Hz. Finally, we
present examples of high dynamic range x-ray imaging spanning more than 4
orders of magnitude dynamic range (from a single photon to 11000
photons/pixel/pulse at 8 keV). Achieving this high performance with only one
auto-ranging switch leads to relatively simple calibration and reconstruction
procedures. The low noise levels allow usage with long integration times at
non-FEL sources. ePix10K cameras leverage the advantages of hybrid pixel
detectors with high production yield and good availability, minimize
development complexity through sharing the hardware, software and DAQ
development with all other versions of ePix cameras, while providing an upgrade
path to 5 kHz, 25 kHz and 100 kHz in three steps over the next few years,
matching the LCLS-II requirements.Comment: 9 pages, 5 figure
Toeplitz operators on symplectic manifolds
We study the Berezin-Toeplitz quantization on symplectic manifolds making use
of the full off-diagonal asymptotic expansion of the Bergman kernel. We give
also a characterization of Toeplitz operators in terms of their asymptotic
expansion. The semi-classical limit properties of the Berezin-Toeplitz
quantization for non-compact manifolds and orbifolds are also established.Comment: 40 page
Field cooling memory effect in Bi2212 and Bi2223 single crystals
A memory effect in the Josephson vortex system created by magnetic field in
the highly anisotropic superconductors Bi2212 and Bi2223 is demonstrated using
microwave power absorption. This surprising effect appears despite a very low
viscosity of Josephson vortices compared to Abrikosov vortices. The
superconductor is field cooled in DC magnetic field H_{m} oriented parallel to
the CuO planes through the critical temperature T_{c} down to 4K, with
subsequent reduction of the field to zero and again above H_{m}. Large
microwave power absorption signal is observed at a magnetic field just above
the cooling field clearly indicating a memory effect. The dependence of the
signal on deviation of magnetic field from H_{m} is the same for a wide range
of H_{m} from 0.15T to 1.7T
Cryptotomography: reconstructing 3D Fourier intensities from randomly oriented single-shot diffraction patterns
We reconstructed the 3D Fourier intensity distribution of mono-disperse
prolate nano-particles using single-shot 2D coherent diffraction patterns
collected at DESY's FLASH facility when a bright, coherent, ultrafast X-ray
pulse intercepted individual particles of random, unmeasured orientations. This
first experimental demonstration of cryptotomography extended the
Expansion-Maximization-Compression (EMC) framework to accommodate unmeasured
fluctuations in photon fluence and loss of data due to saturation or background
scatter. This work is an important step towards realizing single-shot
diffraction imaging of single biomolecules.Comment: 4 pages, 4 figure
Initial-boundary value problems for discrete evolution equations: discrete linear Schrodinger and integrable discrete nonlinear Schrodinger equations
We present a method to solve initial-boundary value problems for linear and
integrable nonlinear differential-difference evolution equations. The method is
the discrete version of the one developed by A. S. Fokas to solve
initial-boundary value problems for linear and integrable nonlinear partial
differential equations via an extension of the inverse scattering transform.
The method takes advantage of the Lax pair formulation for both linear and
nonlinear equations, and is based on the simultaneous spectral analysis of both
parts of the Lax pair. A key role is also played by the global algebraic
relation that couples all known and unknown boundary values. Even though
additional technical complications arise in discrete problems compared to
continuum ones, we show that a similar approach can also solve initial-boundary
value problems for linear and integrable nonlinear differential-difference
equations. We demonstrate the method by solving initial-boundary value problems
for the discrete analogue of both the linear and the nonlinear Schrodinger
equations, comparing the solution to those of the corresponding continuum
problems. In the linear case we also explicitly discuss Robin-type boundary
conditions not solvable by Fourier series. In the nonlinear case we also
identify the linearizable boundary conditions, we discuss the elimination of
the unknown boundary datum, we obtain explicitly the linear and continuum limit
of the solution, and we write down the soliton solutions.Comment: 41 pages, 3 figures, to appear in Inverse Problem
Structure, Time Propagation and Dissipative Terms for Resonances
For odd anharmonic oscillators, it is well known that complex scaling can be
used to determine resonance energy eigenvalues and the corresponding
eigenvectors in complex rotated space. We briefly review and discuss various
methods for the numerical determination of such eigenvalues, and also discuss
the connection to the case of purely imaginary coupling, which is PT-symmetric.
Moreover, we show that a suitable generalization of the complex scaling method
leads to an algorithm for the time propagation of wave packets in potentials
which give rise to unstable resonances. This leads to a certain unification of
the structure and the dynamics. Our time propagation results agree with known
quantum dynamics solvers and allow for a natural incorporation of structural
perturbations (e.g., due to dissipative processes) into the quantum dynamics.Comment: 14 pages; LaTeX; minor change
Skew-self-adjoint discrete and continuous Dirac type systems: inverse problems and Borg-Marchenko theorems
New formulas on the inverse problem for the continuous skew-self-adjoint
Dirac type system are obtained. For the discrete skew-self-adjoint Dirac type
system the solution of a general type inverse spectral problem is also derived
in terms of the Weyl functions. The description of the Weyl functions on the
interval is given. Borg-Marchenko type uniqueness theorems are derived for both
discrete and continuous non-self-adjoint systems too
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