Reproducible process for Titanium deep etching

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Design of a Ti-based microsensor for in vivo pressure monitoring

International audienc

Design of a Ti-based microsensor for in vivo pressure monitoring

International audienc

Effektivitetshämmare inom komplexa M&A-integreringar : - En studie som observerar ledarskapspåverkan

There is a recurring interest and attention regarding the problems with M&A integrations andthe difficulty to implement these successfully. Focus is often set on necessary financialaspects and smart strategic moves but equally important factors such as leadership andculture has recently been shown to be crucial. The purpose of this study has been to identify potential kinds of efficiency drawbacks inchange management situations of complex M&A integrations. Complex M&A integrationshave been designated by constellations of multiple companies, concentrated in differentindustries. The data collection has been a qualitative case study that spanned over three months, locatedinternationally. More than 40 interviews were conducted, in which the majority have beenface-to-face. The co-operating company contributed with employees to interview and gatherknowledge from, where emphasis was placed on differentiating the interviewees to reduceany potential bias. The findings demonstrate many forms of identified efficiency drawbacks, which inconclusions are later categorized into the efficiency drawback lack of leadership. Thisefficiency drawback may be considered critically important to address, advantageouslyproactively for successful M&A integrations.Det förekommer ett återkommande intresse och uppmärksamhet gällande problematiken medM&A-integrationer och att det är så svårt att genomföra lyckade sådana. Fokus hamnar oftapå nödvändiga finansiella aspekter och smarta strategiska drag men minst lika viktigafaktorer såsom ledarskap och kultur har på senare tid visats vara avgörande. Syftet med denna studie har varit att identifiera eventuella former av effektivitetshämmareinom förändringsmiljöer uppkomna av komplexa M&A-integreringar. Med komplexa M&Aintegreringaravses i detta fall M&A-konstellationer av multipel art, det vill säga där fler äntvå företag ingår, koncentrerade inom skilda industrier. För datainsamling har valts en kvalitativ fallstudie som sträckt sig över tre månader,lokaliserad internationellt. Drygt 40 intervjuer har utförts, där majoriteten har varit fysiska.Det samarbetande företaget har hållit med personal att intervjua och samla in kunskap ifrån,där tonvikt har lagts vid att differentiera intervjuobjekten för reducering av eventuell bias. Resultatet påvisar många former av identifierade effektivitetshämmare där slutsatsen senarekategoriserar in dessa i effektivetshämmaren avsaknaden av ledarskap. Dennaeffektivitetshämmare kan således anses kritiskt viktig att åtgärda, fördelaktigen proaktivt, förlyckade M&A-integreringar

Remote wireless control of an enzymatic biofuel cell implanted in a rabbit for 2 months

International audienceA bioelectronic device comprising an enzymatic biofuel cell (GBFC) connected to a wireless tele-transmission system was implanted in a rabbit and its function was monitored and controlled in vivo for a period of 2 months. After the 18th day of implantation, the tele-transmission system was used to wirelessly charge and discharge the operational GBFC in vivo through a 100 kU load for 30 min each day. For a further 16 days of operation, the GBFC delivered 16 mW mL À1 continuously during each 30 min discharge each day for 16 days. At the end of the 2 month period of implantation the power output had diminished, which was most likely due to an inflammatory process. Our results also indicate that the duration of operational activity is increased by optimizing the interface between the GBFC and the body to minimize inflammatory processes and biofouling. These data provide a significant advance in the achievable output from a GBFC that is implanted in a mammal, and importantly provide a basis upon which to further develop stable implantable biofuel cells. Improving the in vivo performance of an implanted GBFC includes the development of biocompatible diffusing polymers to act as buffering diffusion barriers

Microstructuration of titanium for implantable components

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Diagnosis of Menke‐Hennekam syndrome by prenatal whole exome sequencing and review of prenatal signs

Abstract Introduction CREBBP truncating mutations and deletions are responsible for the well‐known Rubinstein‐Taybi syndrome. Recently, a new, distinct CREBBP‐linked syndrome has been described: missense mutations located at the 3′ end of exon 30 and the 5′ portion of exon 31 induce Menke‐Hennekam syndrome. Patients with this syndrome present a recognizable facial dysmorphism, intellectual disability of variable severity, microcephaly, short stature, autism, epilepsy, visual and hearing impairments, feeding problems, upper airway infections, scoliosis, and/or kyphosis. To date, all diagnoses were made postnatally. Method and Case Report Trio‐whole exome sequencing (WES) was performed in a fetus showing increased nuchal translucency persistence and aorta abnormalities at 28 weeks of gestation (WG). Results WES revealed a CREBBP de novo missense mutation (c.5602C>T; p.Arg1868Trp) in exon 31, previously reported as the cause of Menke‐Hennekam syndrome. Termination of pregnancy was performed at 32 WG. We further reviewed the prenatal signs of Menke‐Hennekam syndrome already reported. Among the 35 patients reported and diagnosed postnatally up to this day, 15 presented recognizable prenatal signs, the most frequent being intra‐uterine growth retardation, brain, and cardiovascular anomalies. Conclusion Menke‐Hennekam is a rare syndrome with unspecific, heterogeneous, and inconstant prenatal symptoms occurring most frequently with the c.5602C>T, p.(Arg1868Trp) mutation. Therefore, the prenatal diagnosis of Menke‐Hennekam syndrome is only possible by molecular investigation. Moreover, this case report and review reinforce the importance of performing prenatal WES when unspecific signs are present on imaging

Bulk micromachined Titanium MEMS

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