57 research outputs found
Specific Binding and Mineralization of Calcified Surfaces by Small Peptides
Several small (<25aa) peptides have been designed based on the sequence of the dentin phosphoprotein, one of the major noncollagenous proteins thought to be involved in the mineralization of the dentin extracellular matrix during tooth development. These peptides, consisting of multiple repeats of the tripeptide aspartate-serine-serine (DSS), bind with high affinity to calcium phosphate compounds and, when immobilized, can recruit calcium phosphate to peptide-derivatized polystyrene beads or to demineralized human dentin surfaces. The affinity of binding to hydroxyapatite surfaces increases with the number of (DSS)n repeats, and though similar repeated sequencesā(NTT)n, (DTT)n, (ETT)n, (NSS)n, (ESS)n, (DAA)n, (ASS)n, and (NAA)nāalso showed HA binding activity, it was generally not at the same level as the natural sequence. Binding of the (DSS)n peptides to sectioned human teeth was shown to be tissue-specific, with high levels of binding to the mantle dentin, lower levels of binding to the circumpulpal dentin, and little or no binding to healthy enamel. Phosphorylation of the serines of these peptides was found to affect the avidity, but not the affinity, of binding. The potential utility of these peptides in the detection of carious lesions, the delivery of therapeutic compounds to mineralized tissues, and the modulation of remineralization is discussed
E141 Fourier transform infrared spectroscopic studies on the carbonate identification in carbapatite urinary stones
S37 Long term viscoelastic property assessment of in-vitro aged polypropylene meshes used in female urinary incontinence treatment
E142 Application of thermogravimetric analysis (TGA) to the characterization of calcium oxalate and calcium phosphate urinary stones
VISCOELASTIC RELAXATION ASSESSMENT OF A POLYPROPYLENE SLING USED IN THE TREATMENT OF FEMALE STRESS URINARY INCONTINENCE
pH-responsive polymeric nanoassemblies encapsulated into alginate beads: morphological characterization and swelling studies
The aim of this study is to design and develop novel hybrid pH-responsive hydrogels. For this purpose, new copolymers with different molecular weights and different content of the hydrophobic part are synthesized. The self-assembly behavior of PSMA-co-PDMAEMA copolymerswasstudiedin two different dispersion media (simulated gastric fluid-SGF, pH = 1.2 and simulated intestinal fluid-SIF, pH = 6.8) and in different concentrations. The physicochemical characteristics of the nano-assemblies were found to be dependent on the composition of the copolymer and the aqueous environment. Having a complete knowledge of the self-assembly behavior of the copolymers in aqueous media, the encapsulation of the PSMA-co-PDMAEMA 1/2 nano-assemblies into Alginate beads was achieved by following the protocol of the preparation of hydrogels. The Calcium:Alginate hydrogels were used as reference systems for comparison reasons. The size and the morphology of pure and mixed beads were found to be dependent on the composition of the block copolymer, as revealed from SEM images. The behavior of the mixed hydrogels was the same during the swelling studies, but the rate of the swelling and the amount of weight change were found to be additionally dependent on the composition of the polymeric guest. The hydration state of the polymeric chains plays a key role inthe swelling behavior of the mixed hydrogels. In conclusion, pH-responsive hybrid hydrogels were developed and their behavior and morphology are strongly dependent on the molecular characteristics of the polymeric guest. Ā© 2018, Springer Science+Business Media B.V., part of Springer Nature
C26 LONG TERM EFFECTS OF SIMULTANEOUS TRANSURETHRAL RESECTION OF NON-MUSCLE-INVASIVE BLADDER TUMORS AND BENIGN PROSTATIC HYPERPLASIA: ANALYSIS OF OUR EXPERIENCE
S147 A RANDOMIZED STUDY OF SINGLE DOSE INTRAVESICAL MITOMYCIN-C IN THE TREATMENT OF SUPERFICIAL BLADDER CANCER
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