Pattern Design in the Context Space A Methodological Framework for Auditory Display Design

Common practice in the design of auditory display is hardly ever based on any structured design methodology. This leaves audio being widely underused or used inappropriately and inefficiently. We analyse the current status of research in this context and develop requirements for a methodological framework for auditory display design. Based on these requirements, we have created a framework of methods to capture, transfer and apply design knowledge based on design patterns - paco ad. We present the context space as the organising principle to conceptualise the design space facilitating the matching of design knowledge with solutions and the workflow. Finally, we elaborate on how we intend to evaluate the framework and how it can be supported by tools

Mucronatine, a new N-methyl purine from the french mediterranean marine sponge Stryphnus mucronatus

A new N-methyl purine, mucronatine 1, was isolated from the French marine sponge Stryphnus mucronatus. Its structure was determined by detailed 2D spectroscopic analysis, including 15N spectral data assignments

New polychlorinated pyrrolidinones from the Red Sea marine sponge Lamellodysidea herbacea

Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of seven new polychlorinated derivatives 3-6 and 8-10 in addition to the known dysidamide 1, dysidamide B 2 and dysidamide C 7. Their structures were established by extensive NMR spectroscopic data. The absolute configuration of compound 9 was determined by X-ray crystallographic diffraction analysis. Dysidamide 1 exhibited neurotoxic effects towards both mesencephalic and cortical murine neurones at 0.8 μg/ml. Seven new polychlorinated derivatives have been isolated in addition to the known dysidamide, dysidamide B and dysidamide C from the Red Sea marine sponge Lamellodysidea herbacea. Their structures were established by extensive spectroscopic methods. Dysidamide exhibited neurotoxic effects towards both mesencephalic and cortical murine neurones at 0.8 μg/ml

New polychlorinated derivatives from the Red Sea marine sponge

Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of seven new polychlorinated derivatives 3-6 and 8-10 in addition to the known dysidamide 1, dysidamide B 2 and dysidamide C 7. Their structures were established by extensive NMR spectroscopic data. The absolute configuration of compound 9 was determined by X-ray crystallographic diffraction analysis. Dysidamide 1 exhibited neurotoxic effects towards both mesencephalic and cortical murine neurones at 0.8 μg/ml. Seven new polychlorinated derivatives have been isolated in addition to the known dysidamide, dysidamide B and dysidamide C from the Red Sea marine sponge Lamellodysidea herbacea. Their structures were established by extensive spectroscopic methods. Dysidamide exhibited neurotoxic effects towards both mesencephalic and cortical murine neurones at 0.8 μg/ml

Coscinolactams A and B : new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties

Investigation of the marine sponge Coscinoderma mathewsi led to the isolation of two novel nitrogen-containing cheilanthane sesterterpenoids, coscinolactams A and B, together with known suvanine. The structures were elucidated by extensive spectroscopic measurements including NOE experiments to deduce the stereochemistry. The natural compounds, as well as a semisynthetic derivative, showed moderate anti-inflammatory activity measured as their capability to inhibit PGE2 and NO production. The suvanine aldehyde derivative 4 inhibited inducible nitric oxide protein expression with an IC50 value of 7.3 μM