Effect of Network Topology on Neighbourhood-Aided Collective Learning

International audienceThis article is about multi-agent collective learning in networks. An agent revises its current model when collecting a new observation inconsistent with it. While revising, the agent interacts with its neighbours in the community, and benefits from observations that other agents send on a utility basis. When considering the learning speed of an agent with respect to all the observations within the community, it clearly depends on the neighbourhood structure, i.e. on the network topology. A comprehensive experimental study characterizes this influence, showing the main factors that affect neighbourhood-aided collective learning. Two kinds of informations are propagated in the networks: hypotheses and counter-examples. This study also weights the impact of these propagation by considering some variants in which one kind of propagation is stopped. Our main purpose is to understand how network characteristics affect to what extent the agents learn and share models and observations, and consequently the learning speed within the community

Impact of Epicatechin on the Procoagulant Activities of Microparticles

International audienceMicroparticles play a role in cardiovascular disease pathology. The flavanol-like epicatechin is increasingly considered due to its cardioprotective effects. The aim of this study was to investigate the impact of epicatechin on microparticle generation, phenotype and procoagulant properties. Plasma samples from 15 healthy subjects were incubated with increasing concentrations of epicatechin (1 to 100 mu M). Then, the expression of glycoprotein IIb, phosphatidylserine (PS), glycoprotein Ib (GPIb) and P-selectin was assessed by flow cytometry analysis after (or not) platelet stimulation. Microparticle procoagulant activity was determined using Zymuphen MP and Zymuphen (TM) MP-TF for phospholipid and tissue factor content, and with thrombin generation (TG) assays for procoagulant function. Platelet microparticles that express GPIb (/mu L) decreased from 20,743 +/- 24,985 (vehicle) to 14,939 +/- 14,333 (p = 0.6), 21,366 +/- 16,949 (p = 0.9) and 15,425 +/- 9953 (p < 0.05) in samples incubated with 1, 10 and 100 mu M epicatechin, respectively. Microparticle concentration (nM PS) decreased from 5.6 +/- 2.0 (vehicle) to 5.1 +/- 2.2 (p = 0.5), 4.5 +/- 1.5 (p < 0.05) and 4.7 +/- 2.0 (p < 0.05) in samples incubated with 1, 10 and 100 mu M epicatechin, respectively. Epicatechin had no impact on tissue factor-positive microparticle concentration. Epicatechin decreased TG (endogenous thrombin potential, nM.min) from 586 +/- 302 to 509 +/- 226 (p = 0.3), 512 +/- 270 (p = 0.3) and 445 +/- 283 (p < 0.05). These findings indicate that epicatechin affects microparticle release, phenotype and procoagulant properties

Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay

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The Spliceosome: An Another Regulating System of Gene Expression Deregulated in CP-CML CD34+CD15- Cells

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Le spliceosome : un autre mécanisme de régulation des gènes impliqués dans l’hétérogénéité intra-clonale de la Leucémie Myéloïde Chronique ?

# 09-01International audienc