489 research outputs found

    A semantic study of the terms designating buildings and agglomerations in Old French literary texts (ca. 1150 - 1300)

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    This study sets out to consider the terms used to designate buildings and agglomerations in Old French literary texts dated from c. 1150 to c. 1300. It begins with a definition of the field of vocabulary under review and a chronological enumeration of the texts from which our observations are made. There follows a discussion of various former and current theories on the possible semantic treatment of such a field of vocabulary. It is proposed that the field be considered as a structured whole; the units making up this structure are identified from textual examples, and the different relationships obtaining between the units are defined and illustrated. An onomasiological study presents all the terms which may occur within each unit, making special reference to their relative frequency, meaningfulness and stylistic nuance. Next, treating each term individually, there follows a semasiological study. This consists of commentaries on the conception of each term hitherto held and on the new conceptions which result from the closer definition made possible by our structural approach. Consequent lacunae in the Old French dictionaries are pointed out. The advantages of this kind of approach are next discussed, and the possible practical application of this study illustrated by means of a number of critical essays on the defined field of vocabulary in individual texts. The aim of this thesis is to present this section of Old French vocabulary as a whole and in relief, and our claim is that it will enable compilers of dictionaries and of glossaries to individual texts to assess each term in the field against the background of a structured and clearly dimensioned whole.<p

    Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

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    Chromosome synapsis during zygotene is a prerequisite for the timely homologous recombinational repair of meiotic DNA double-strand breaks (DSBs). Unrepaired DSBs are thought to trigger apoptosis during midpachytene of male meiosis if synapsis fails. An early pachytene response to asynapsis is meiotic silencing of unsynapsed chromatin (MSUC), which, in normal males, silences the X and Y chromosomes (meiotic sex chromosome inactivation [MSCI]). In this study, we show that MSUC occurs in Spo11-null mouse spermatocytes with extensive asynapsis but lacking meiotic DSBs. In contrast, three mutants (Dnmt3l, Msh5, and Dmc1) with high levels of asynapsis and numerous persistent unrepaired DSBs have a severely impaired MSUC response. We suggest that MSUC-related proteins, including the MSUC initiator BRCA1, are sequestered at unrepaired DSBs. All four mutants fail to silence the X and Y chromosomes (MSCI failure), which is sufficient to explain the midpachytene apoptosis. Apoptosis does not occur in mice with a single additional asynapsed chromosome with unrepaired meiotic DSBs and no disturbance of MSCI

    Energy Statistics, 1968 - No. 3

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