The ICRC in Central Africa in the end of the 20 th century : Case study of Cameroon, Congo-Brazzaville, RDCongo and Gabon, from 1960 up to 1999

Le comité international de la Croix-Rouge en abrégé CICR est une organisation humanitaire fondée en 1863 par le Comité de cinq citoyens suisses: Gustave Moynier, Henri Dunant, Guillaume Dufour, Louis Appia, Théodore Maunoir. Crée à la base pour secourir et venir en aide aux victimes de guerre, sur une initiative d'Henri Dunant d'après un souvenir de la Guerre de Solferino, le CICR élargira son champ d'action après la Convention de Genève de 1949. En effet, le CICR est l'ONG la plus représentée dans le monde et c'est à juste titre qu'elle fut Prix-Nobel de la paix en 1901 remis à Henri Dunant, en 1917, 1944, 1963, pour son effort lors des différents conflits, mais aussi le prix Balzan pour l'humanité, la paix et la fraternité entre les peuples en 1996. Elle s'est établie progressivement dans tous les continents après la seconde Guerre Mondiale. Avant cela, elle n'était qu'une ONG essentiellement européenne. En Afrique Centrale, la délégation de la Croix-Rouge Internationale était basée à Yaoundé au Cameroun et comprenait les pays d'Afrique Centrale tels que le Congo, la RD Congo, le Gabon, la Guinée Equatoriale et le Sao-Tomé. Dans ces pays l'oeuvre du CICR varie selon les besoins Humanitaires des uns et des autres. En effet, plus un Etat est en guerre, plus l’intervention du CICR est importante. Cette intervention se fait dans le respect des règles établies lors des différentes Conventions de Genève, de la Haye et bien d’autres encore. De ces différentes conférences est né le Droit international humanitaire qui codifie l’action du CICR sur le terrain, surtout en temps de guerre, mais aussi celles des autres ONG, y compris les entités onusiennes. Le Droit international est le respect des Droits de l’homme et son environnement en période de conflit armé. Ainsi l’action du CICR en Afrique Centrale a été plus importante en République Démocratique du Congo qu’au Gabon qui est resté sans conflits guerriers depuis 1960, date de départ de notre borne chronologique. Les pays qui font l’objet de notre étude ont connu diverses péripéties : la guerre de Bakassi pour le Cameroun, la guerre civile du Congo Brazzaville et la guerre à multiples facettes interminable en République Démocratique du Congo. L’intervention du CICR en temps de paix est souvent confiée aux Sociétés nationales qui doivent former les secouristes, diffuser le Droit international humanitaire, entre autres de leurs activités quotidiennes de supplier les gouvernements dans leurs missions de santé, d’hygiène. Même cette mission du CICR en temps de paix vise la limitation des dégâts en temps de guerre.The International Committee of the Red Cross ICRC abstract is a humanitarian organization founded in 1863 by the Committee of five Swiss citizens: Moynier, Henry Dunant, Guillaume Dufour, Louis Appia, ThéodoreMaunoir. Creates the basis for the relief and assistance to victims of war, an initiative of Henry Dunant from a memory of the War of Solferino, the ICRC will extend its scope after the Geneva Convention of 1949. In Indeed, the ICRC is the NGO most represented in the world and it is appropriate that it was price-Nobel Peace Prize in 1901 awarded to Henri Dunant, in 1917, 1944, 1963 for his effort during the different conflicts, but also the Balzan Prize for humanity, peace and brotherhood among peoples in 1996. It was established gradually in all continents after the Second World War. Before that, she was a mostly European NGOs. In Central Africa, the delegation of the International Red Cross is based in Yaounde, Cameroon and includes the Central African countries such as Congo, DR Congo, Gabon, Equatorial Guinea and Sao Tome. In these countries the work of the ICRC varies Humanitarian needs of each other. The more a country is at war, most of the ICRC's intervention is important. This procedure is done in accordance with the rules established in the various Geneva Conventions, the Hague and many others. Of these conferences was born on international humanitarian law that codifies the ICRC's work in the field, especially in time of war, but also those of other NGOs, including UN entities. International law is respect for human rights and the environment in times of armed conflict. Thus the ICRC's work in Central Africa was greater in Democratic Republic of Congo and Gabon, which remained without military conflicts since 1960, starting date of our chronological terminal. The countries that are the subject of our study experienced various vicissitudes: Bakassi war for Cameroon, the civil war in Congo Brazzaville and war multifaceted ending in the Democratic Republic of Congo. The intervention of the ICRC in time of peace is often left to National Societies must train rescuers dissemination of international humanitarian law, including their daily activities to beg governments in their health missions, hygiene. Even the ICRC mission in peacetime is damage limitation in time of war

Le Comité international de la Croix-Rouge en Afrique centrale à la fin du XXe siècle : cas du Cameroun, du Congo Brazzaville, du Congo Kinshasa et du Gabon de 1960 à 1999

The International Committee of the Red Cross ICRC abstract is a humanitarian organization founded in 1863 by the Committee of five Swiss citizens: Moynier, Henry Dunant, Guillaume Dufour, Louis Appia, ThéodoreMaunoir. Creates the basis for the relief and assistance to victims of war, an initiative of Henry Dunant from a memory of the War of Solferino, the ICRC will extend its scope after the Geneva Convention of 1949. In Indeed, the ICRC is the NGO most represented in the world and it is appropriate that it was price-Nobel Peace Prize in 1901 awarded to Henri Dunant, in 1917, 1944, 1963 for his effort during the different conflicts, but also the Balzan Prize for humanity, peace and brotherhood among peoples in 1996. It was established gradually in all continents after the Second World War. Before that, she was a mostly European NGOs. In Central Africa, the delegation of the International Red Cross is based in Yaounde, Cameroon and includes the Central African countries such as Congo, DR Congo, Gabon, Equatorial Guinea and Sao Tome. In these countries the work of the ICRC varies Humanitarian needs of each other. The more a country is at war, most of the ICRC's intervention is important. This procedure is done in accordance with the rules established in the various Geneva Conventions, the Hague and many others. Of these conferences was born on international humanitarian law that codifies the ICRC's work in the field, especially in time of war, but also those of other NGOs, including UN entities. International law is respect for human rights and the environment in times of armed conflict. Thus the ICRC's work in Central Africa was greater in Democratic Republic of Congo and Gabon, which remained without military conflicts since 1960, starting date of our chronological terminal. The countries that are the subject of our study experienced various vicissitudes: Bakassi war for Cameroon, the civil war in Congo Brazzaville and war multifaceted ending in the Democratic Republic of Congo. The intervention of the ICRC in time of peace is often left to National Societies must train rescuers dissemination of international humanitarian law, including their daily activities to beg governments in their health missions, hygiene. Even the ICRC mission in peacetime is damage limitation in time of war.Le comité international de la Croix-Rouge en abrégé CICR est une organisation humanitaire fondée en 1863 par le Comité de cinq citoyens suisses: Gustave Moynier, Henri Dunant, Guillaume Dufour, Louis Appia, Théodore Maunoir. Crée à la base pour secourir et venir en aide aux victimes de guerre, sur une initiative d'Henri Dunant d'après un souvenir de la Guerre de Solferino, le CICR élargira son champ d'action après la Convention de Genève de 1949. En effet, le CICR est l'ONG la plus représentée dans le monde et c'est à juste titre qu'elle fut Prix-Nobel de la paix en 1901 remis à Henri Dunant, en 1917, 1944, 1963, pour son effort lors des différents conflits, mais aussi le prix Balzan pour l'humanité, la paix et la fraternité entre les peuples en 1996. Elle s'est établie progressivement dans tous les continents après la seconde Guerre Mondiale. Avant cela, elle n'était qu'une ONG essentiellement européenne. En Afrique Centrale, la délégation de la Croix-Rouge Internationale était basée à Yaoundé au Cameroun et comprenait les pays d'Afrique Centrale tels que le Congo, la RD Congo, le Gabon, la Guinée Equatoriale et le Sao-Tomé. Dans ces pays l'oeuvre du CICR varie selon les besoins Humanitaires des uns et des autres. En effet, plus un Etat est en guerre, plus l’intervention du CICR est importante. Cette intervention se fait dans le respect des règles établies lors des différentes Conventions de Genève, de la Haye et bien d’autres encore. De ces différentes conférences est né le Droit international humanitaire qui codifie l’action du CICR sur le terrain, surtout en temps de guerre, mais aussi celles des autres ONG, y compris les entités onusiennes. Le Droit international est le respect des Droits de l’homme et son environnement en période de conflit armé. Ainsi l’action du CICR en Afrique Centrale a été plus importante en République Démocratique du Congo qu’au Gabon qui est resté sans conflits guerriers depuis 1960, date de départ de notre borne chronologique. Les pays qui font l’objet de notre étude ont connu diverses péripéties : la guerre de Bakassi pour le Cameroun, la guerre civile du Congo Brazzaville et la guerre à multiples facettes interminable en République Démocratique du Congo. L’intervention du CICR en temps de paix est souvent confiée aux Sociétés nationales qui doivent former les secouristes, diffuser le Droit international humanitaire, entre autres de leurs activités quotidiennes de supplier les gouvernements dans leurs missions de santé, d’hygiène. Même cette mission du CICR en temps de paix vise la limitation des dégâts en temps de guerre

The ICRC in Central Africa in the end of the 20 th century : Case study of Cameroon, Congo-Brazzaville, RDCongo and Gabon, from 1960 up to 1999

Le comité international de la Croix-Rouge en abrégé CICR est une organisation humanitaire fondée en 1863 par le Comité de cinq citoyens suisses: Gustave Moynier, Henri Dunant, Guillaume Dufour, Louis Appia, Théodore Maunoir. Crée à la base pour secourir et venir en aide aux victimes de guerre, sur une initiative d'Henri Dunant d'après un souvenir de la Guerre de Solferino, le CICR élargira son champ d'action après la Convention de Genève de 1949. En effet, le CICR est l'ONG la plus représentée dans le monde et c'est à juste titre qu'elle fut Prix-Nobel de la paix en 1901 remis à Henri Dunant, en 1917, 1944, 1963, pour son effort lors des différents conflits, mais aussi le prix Balzan pour l'humanité, la paix et la fraternité entre les peuples en 1996. Elle s'est établie progressivement dans tous les continents après la seconde Guerre Mondiale. Avant cela, elle n'était qu'une ONG essentiellement européenne. En Afrique Centrale, la délégation de la Croix-Rouge Internationale était basée à Yaoundé au Cameroun et comprenait les pays d'Afrique Centrale tels que le Congo, la RD Congo, le Gabon, la Guinée Equatoriale et le Sao-Tomé. Dans ces pays l'oeuvre du CICR varie selon les besoins Humanitaires des uns et des autres. En effet, plus un Etat est en guerre, plus l’intervention du CICR est importante. Cette intervention se fait dans le respect des règles établies lors des différentes Conventions de Genève, de la Haye et bien d’autres encore. De ces différentes conférences est né le Droit international humanitaire qui codifie l’action du CICR sur le terrain, surtout en temps de guerre, mais aussi celles des autres ONG, y compris les entités onusiennes. Le Droit international est le respect des Droits de l’homme et son environnement en période de conflit armé. Ainsi l’action du CICR en Afrique Centrale a été plus importante en République Démocratique du Congo qu’au Gabon qui est resté sans conflits guerriers depuis 1960, date de départ de notre borne chronologique. Les pays qui font l’objet de notre étude ont connu diverses péripéties : la guerre de Bakassi pour le Cameroun, la guerre civile du Congo Brazzaville et la guerre à multiples facettes interminable en République Démocratique du Congo. L’intervention du CICR en temps de paix est souvent confiée aux Sociétés nationales qui doivent former les secouristes, diffuser le Droit international humanitaire, entre autres de leurs activités quotidiennes de supplier les gouvernements dans leurs missions de santé, d’hygiène. Même cette mission du CICR en temps de paix vise la limitation des dégâts en temps de guerre.The International Committee of the Red Cross ICRC abstract is a humanitarian organization founded in 1863 by the Committee of five Swiss citizens: Moynier, Henry Dunant, Guillaume Dufour, Louis Appia, ThéodoreMaunoir. Creates the basis for the relief and assistance to victims of war, an initiative of Henry Dunant from a memory of the War of Solferino, the ICRC will extend its scope after the Geneva Convention of 1949. In Indeed, the ICRC is the NGO most represented in the world and it is appropriate that it was price-Nobel Peace Prize in 1901 awarded to Henri Dunant, in 1917, 1944, 1963 for his effort during the different conflicts, but also the Balzan Prize for humanity, peace and brotherhood among peoples in 1996. It was established gradually in all continents after the Second World War. Before that, she was a mostly European NGOs. In Central Africa, the delegation of the International Red Cross is based in Yaounde, Cameroon and includes the Central African countries such as Congo, DR Congo, Gabon, Equatorial Guinea and Sao Tome. In these countries the work of the ICRC varies Humanitarian needs of each other. The more a country is at war, most of the ICRC's intervention is important. This procedure is done in accordance with the rules established in the various Geneva Conventions, the Hague and many others. Of these conferences was born on international humanitarian law that codifies the ICRC's work in the field, especially in time of war, but also those of other NGOs, including UN entities. International law is respect for human rights and the environment in times of armed conflict. Thus the ICRC's work in Central Africa was greater in Democratic Republic of Congo and Gabon, which remained without military conflicts since 1960, starting date of our chronological terminal. The countries that are the subject of our study experienced various vicissitudes: Bakassi war for Cameroon, the civil war in Congo Brazzaville and war multifaceted ending in the Democratic Republic of Congo. The intervention of the ICRC in time of peace is often left to National Societies must train rescuers dissemination of international humanitarian law, including their daily activities to beg governments in their health missions, hygiene. Even the ICRC mission in peacetime is damage limitation in time of war

Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds

Photograph used for a newspaper owned by the Oklahoma Publishing Company. Caption: "(photo looking up a building's side that has an outwards build where the window are located and a fence or something similar at the front of the camera)

The Contributive Role of IGFBP-3 and Mitochondria in Synoviocyte-Induced Osteoarthritis through Hypoxia/Reoxygenation Injury: A Pathogenesis-Focused Literature Review

Osteoarthritis (OA), one of the most common joint disorders, is characterized by chronic progressive cartilage degradation, osteophyte formation, and synovial inflammation. OA lesions are not only located in articular cartilage but also in the entire synovial joint. Nevertheless, most of the early studies done mostly focused on the important role of chondrocyte apoptosis and cartilage degeneration in the pathogenesis and progress of OA. The increased expression of hypoxia-inducible factors (HIF-1α and HIF-2α) is known to be the cellular and biochemical signal that mediates the response of chondrocytes to hypoxia. The role of the synovium in OA pathogenesis had been poorly evaluated. Being sensitive to hypoxia/reoxygeneration (H/R) injury, fibroblast-like synoviocytes (FLS) play an essential role in cartilage degradation during the course of this pathology. Insulin-like growth factor binding protein 3 (IGFBP-3) acts as the main carrier of insulin-like growth factor I (IGF-I) in the circulation and remains the most abundant among the six IGFBPs. Synovial fluids of OA patients have markedly increased levels of IGFBP-3. We aim to discuss the interconnected behavior of IGFBP-3 and synoviocytes during the course of osteoarthritis pathogenesis, especially under the influence of hypoxia-inducible factors. In this review, we present information related to the essential role that is played by IGFBP-3 and mitochondria in synoviocyte-induced osteoarthritis through H/R injury. Little research has been done in this area. However, strong evidences show that the level of IGFBP-3 in synovial fluid significantly increased in OA, inhibiting the binding of IGF-1 to IGFR 1 (IGF receptor-1) and therefore the inhibition of cell proliferation. To the best of our knowledge, this is the first paper providing a comprehensive explanatory contribution of IGFBP-3 and mitochondria in synovial cell-induced osteoarthritis through hypoxia/reoxygenation mechanism

Assessment and evaluation efficacy of a clinical pharmacist-led inpatient warfarin knowledge education program and follow-up at a Chinese tertiary referral teaching hospital

Background: Oral anticoagulation therapy with warfarin is used to prevent and to treat venous and arterial thrombosis and embolism. Its narrow therapeutic index should be monitored carefully in order to reach the desired outcomes. Objective: This study aims to evaluate the clinical pharmacist-led in-patient warfarin′s knowledge education program and to assess a follow-up efficacy in a Chinese tertiary referral teaching hospital. Design and Setting: A cross-sectional and observational study was conducted at the Affiliated Hospital of Medical College of Nanjing University, a 1460-bed tertiary referral teaching hospital in Nanjing. Materials and Methods: One-on-one interview questionnaire was conducted among 47 Chinese patients who had undergone prosthetic valve replacement. Before the patient education program′s implemented, at discharge time and 3 months, 6-9 months and 12 months after surgery were considered as time points. A previously validated 17-item questionnaire was used to measure the patient′s knowledge level of warfarin and to assess and evaluate a follow-up efficacy of this patient education program run by a clinical pharmacist. Knowledge scores were compared using the Student′s t-test or one-way analysis of variance. Main Outcome Measure: Patients′ knowledge on the warfarin education program and warfarin knowledge score, drug therapy problems or bleeding complication events associated to warfarin therapy and evaluation of clinical pharmacist′s service provided. Results: Patients mean age was 47.68 ΁ 9.70 years (range 23-67). The higher education strata had significantly higher warfarin knowledge scores (P < 0.05). In terms of hospital stay post-surgery, compared with other groups, patients with an average of 11-14 days, were found significantly and statically higher knowledgeable in warfarin (P < 0.05). The clinical pharmacist′ service was found very satisfying f(80.85%). Conclusion: Chinese patients on warfarin therapy should benefit from periodic educational efforts reinforcing key medication safety information. Patient education is not a once-off procedure. A complete patient education program run by a clinical pharmacist in a Cardio-thoracic ward can considerably improve and enhance to reduce the hospital stays and significantly enlighten the role of the patient education in adherence to therapy