Effect of Family Education on Clinical Outcomes in Children with Asthma: A Review

Childhood asthma still imposes an enormous burden on children and their families. To the best of our knowledge, no study reviewed the literature on the effect of family asthma education on major asthma outcomes. This study aimed to explore the effect of family education programs on major asthma outcomes in children. Quasi-experimental studies and randomized controlled trials were conducted among children with asthma aged 6–18 years and their parents were included. Pub Med, Science Direct, and Trip databases were used to extract data published in English from 2010 to 2021. Twenty-two studies were reported in this review. It was demonstrated that family empowerment interventions were effective in improving the quality of life of children and their parents, asthma symptom control, and pulmonary function. Family education that was specific to medication improved medication adherence, inhalation technique, and asthma control. Family asthma education enhanced asthma management and family functioning. This approach should be a cornerstone of pediatric asthma therapy. It helps health care professionals to build a strong connection and trustful relationship with children with asthma and their families

Diagnosis of Fucosidosis through Cutaneous Manifestations

El objetivo central de este trabajo es analizar la crítica al naturalismo formulada por la corriente denominada feminismo materialista francés (FMF). Mostraremos que la crítica que dicha corriente elabora permite desmontar tempranamente, desde principios de la década de 1970, diversos biologicismos, tanto en el campo del marxismo como del feminismo teórico. De este modo, demostraremos que el FMF provee un marco epistémico alternativo al sistema sexo/género, tal como era desarrollado por la misma época en la literatura anglófona (a partir de los trabajos de Ann Oakley y Gayle Rubin) y que permite pensar "antes del género y más allá de él" (tomamos prestada la expresión de Falquet, 2018). Esta investigación se despliega a la luz de una inquietud general: la necesidad de recuperar líneas de pensamiento que quedan ocultas bajo la sedimentación de las narrativas hegemónicas. En este caso, se trata de abordar teorías que se encuentran fuera del feminismo mainstream, con clara preeminencia estadounidense. Es por esto que en este trabajo, retomamos la propuesta benjaminiana de construir una historia a contrapelo que descubra, entre las diferentes capas o estratos del relato hegemónico, los restos de otros relatos. El feminismo materialista francés, que surge al fragor de los tumultuosos años sesenta y principios de los setenta, quedará sepultado en los años posteriores. ¿Cuáles son los motivos de esta invisibilización? ¿Por qué el FMF pasó desapercibido durante tanto tiempo, e incluso hoy, cómo es que casi no conocemos los nombres de estas autoras: Christine Delphy, Colette Guillaumin, Paola Tabet y Nicole-Claude Mathieu? Para abordar estos interrogantes, proponemos un análisis del feminismo materialista francés desde una nueva perspectiva: aquella que aportan los estudios contemporáneos sobre la división académica del conocimiento global, desde una perspectiva situada en el Sur, para contribuir tanto a los estudios feministas como al gran campo de saberes sobre la circulación internacional de teorías.Universidad Nacional de La Plat

Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia

<div><p>This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of <i>Streptococcus pneumoniae</i> 16S rDNA using real-time PCR. The viral distribution and its association with clinical symptoms were statistically analyzed. Viral pathogens were detected in 342 (91.93%) of the samples of which 28.76% were single positive and 63.17% had multiple infections. The most frequent detected viruses were rhinovirus (55.64%), respiratory syncytial virus A/B (33.06%), adenovirus (25.00%), coronavirus NL63, HKU1, OC43, and 229E (21.50%), and metapneumovirus A/B (16.12%). Children in the youngest age group (1–3 months) exhibited the highest frequencies of infection. Related to their frequency of detection, RSV A/B was the most associated pathogen with patient’s demographic situation and clinical manifestations (p<0.05). Parainfluenza virus 1–4 and parechovirus were found to increase the risk of death (p<0.05). Adenovirus was statistically associated to the manifestation of gastroenteritis (p = 0.004). Rhinovirus infection increases the duration of oxygen support (p = 0.042). Coronavirus group was statistically associated with the manifestation of bronchiolitis (p = 0.009) and laryngitis (p = 0.017). <i>Streptococcus pneumoniae</i> DNA was detected in 143 (38.44%) of tested samples. However, only 53 samples had a concentration of C-reactive protein from equal to higher than 20 milligrams per liter, and 6 of them were single positive for <i>Streptocuccus pneumoniae</i>. This study confirms the high incidence of respiratory viruses in children hospitalized for acute respiratory tract infections in the Sousse area, Tunisia.</p></div

Summary of the statistical comparisons between positive viral infection and patient’s medical history, demographic data and clinical manifestations.

<p>Summary of the statistical comparisons between positive viral infection and patient’s medical history, demographic data and clinical manifestations.</p

Summary of the statistical associations comparing single and multiple viral infections with patient’s data.

<p>Summary of the statistical associations comparing single and multiple viral infections with patient’s data.</p

Diagnostic moléculaire de la dyskinésie ciliaire primitive dans une cohorte tunisienne : identification d’un allèle majeur

National audiencePrimary ciliary dyskinesia (PCD) is a genetically heterogeneous disease of motile cilia. Even though PCD is widely studied, North-African patients have been rarely explored. In this study, we aim at confirming the clinical diagnosis and explore the genetic spectrum of PCD in a cohort of Tunisian patients. Forty clinically diagnosed patients with PCD belonging to 34 families were recruited from Tunisian pediatric departments. In each proband, targeted capture PCD panel sequencing of the 40 PCD genes was performed. PCD panel sequencing identified bi-allelic mutations in 82% of the families in eight PCD genes. Remarkably, 23.5% of patients carried the same c.2190del CCDC39 mutation. Single nucleotide polymorphism profiling in six unrelated patients carrying this mutation has revealed a founder effect in North-African patients. This mutation is estimated to date back at least 1,400-1,750 years ago. The identification of this major allele allowed us to suggest a cost-effective genetic diagnostic strategy in North-African patients with PCD

Characteristics of <i>S</i>. <i>pneumoniae</i> infected subjects in relation to viral infection (negative, single and multiple) and CRP concentrations^a.

<p>Characteristics of <i>S</i>. <i>pneumoniae</i> infected subjects in relation to viral infection (negative, single and multiple) and CRP concentrations<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188325#t003fn001" target="_blank">^a</a>.</p