Safety Concern between Autologous Fat Graft, Mesenchymal Stem Cell and Osteosarcoma Recurrence

Background: Osteosarcoma is the most common malignant primary bone tumour in young adult treated by neo adjuvant chemotherapy, surgical tumor removal and adjuvant multidrug chemotherapy. For correction of soft tissue defect consecutive to surgery and/or tumor treatment, autologous fat graft has been proposed in plastic and reconstructive surgery. Principal Findings: We report here a case of a late local recurrence of osteosarcoma which occurred 13 years after the initial pathology and 18 months after a lipofilling procedure. Because such recurrence was highly unexpected, we investigated the possible relationship of tumor growth with fat injections and with mesenchymal stem/stromal cell like cells which are largely found in fatty tissue. Results obtained in osteosarcoma pre-clinical models show that fat grafts or progenitor cells promoted tumor growth. Significance: These observations and results raise the question of whether autologous fat grafting is a safe reconstructive procedure in a known post neoplasic context

Passive stochastic matched filter for Antarctic blue whale call detection

As a first step to Antarctic blue whale (ABW) monitoring using passive acoustics, a method based on the stochastic matched filter (SMF) is proposed. Derived from the matched filter (MF), this filter-based denoising method enhances stochastic signals embedded in an additive colored noise by maximizing its output signal to noise ratio (SNR). These assumptions are well adapted to the passive detection of ABW calls where emitted signals are modified by the unknown impulse response of the propagation channel. A filter bank is computed and stored offline based on a priori knowledge of the signal second order statistics and simulated colored sea-noise. Then, the detection relies on online background noise and SNR estimation, realized using time-frequency analysis. The SMF output is cross-correlated with the signal's reference (SMF þ MF). Its performances are assessed on an ccean bottom seismometer-recorded ground truth dataset of 845 ABW calls, where the location of the whale is known. This dataset provides great SNR variations in diverse soundscapes. The SMF þ MF performances are compared to the commonly used MF and to the Z-detector (a sub-space detector for ABW calls). Mostly, the benefits of the use of the SMF þ MF are revealed on low signal to noise observations: in comparison to the MF with identical detection threshold, the false alarm rate drastically decreases while the detection rate stays high. Compared to the Z-detector, it allows the extension of the detection range of ' 30 km in presence of ship noise with equivalent false discovery rate.Imagerie mantellique du point chaud de La Réunio