5 research outputs found

    Demonstrating a Perimeter Trap Crop Approach to Pest Management on Summer Squash in New England

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    Perimeter trap cropping (PTC) involves using a trap crop, and possibly other border defenses, to encircle and protect the main cash crop like fortress walls. Six growers in Connecticut used PTC to protect commercial summer squash plantings from cucumber beetles and bacterial wilt damage. Grower surveys were used to compare PTC program results to the conventional multiple-full-field-spray system formerly used on the farms. Most growers using PTC stated that this system improved and simplified pest control, reduced pesticide use (93%) and crop loss, and saved them time and money compared to their conventional program

    Compartmentation of Redox Metabolism in Malaria Parasites

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    Malaria, caused by the apicomplexan parasite Plasmodium, still represents a major threat to human health and welfare and leads to about one million human deaths annually. Plasmodium is a rapidly multiplying unicellular organism undergoing a complex developmental cycle in man and mosquito – a life style that requires rapid adaptation to various environments. In order to deal with high fluxes of reactive oxygen species and maintain redox regulatory processes and pathogenicity, Plasmodium depends upon an adequate redox balance. By systematically studying the subcellular localization of the major antioxidant and redox regulatory proteins, we obtained the first complete map of redox compartmentation in Plasmodium falciparum. We demonstrate the targeting of two plasmodial peroxiredoxins and a putative glyoxalase system to the apicoplast, a non-photosynthetic plastid. We furthermore obtained a complete picture of the compartmentation of thioredoxin- and glutaredoxin-like proteins. Notably, for the two major antioxidant redox-enzymes – glutathione reductase and thioredoxin reductase – Plasmodium makes use of alternative-translation-initiation (ATI) to achieve differential targeting. Dual localization of proteins effected by ATI is likely to occur also in other Apicomplexa and might open new avenues for therapeutic intervention
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