Aerobic oxidation of aryl-himachalene using a combination of N-hydroxy phthalimide and cobalt(II) acetoacetate

An efficient aerobic oxidation of Ar-himachalene as bio-natural sesquiterpene employing the N-hydroxyphthalimide (NHPI), under mild conditions in presence of cobalt (II) afforded the corresponding alcohol, aldehyd and carboxylic acid in excellent yield and good selectivities. Keywords : Aerobic oxidation, Ar-himachalene, sesquiterpene, NHPI

Natural phosphate as new, highly efficient and reusable heterogeneous catalyst for the selective preparation of beta-enaminoesters under solvent-free conditions

Natural phosphate (NP) has been found to be a new and highly efficient heterogeneous catalyst for the synthesis of beta-enaminoesters, by simple condensation of various primary amines with beta-dicarbonyl under solvent-free conditions. Keywords: Natural phosphate (NP), b-enaminoesters, solvent-free condition

(5R)-5-[(1R)-2,2-Dichloro-1-methyl­cyclo­prop­yl]-2-methyl­cyclo­hex-2-en-1-one

The title compound, C11H14Cl2O, was synthesized by the reaction of a dichloro­methane solution of (R)-carvone and potassium tert-butano­late in the presence of a catalytic amount of benzyl­triethyl­ammonium chloride in chloro­form. The cyclo­hexene ring adopts a half-boat conformation. The cyclo­propyl ring is unsymmetrical, the shortest C—C bond being distal to the alkyl-substituted C atom. The crystal packing is stabilized only by van der Waals inter­actions

Development of a Sustainable and Solventless Friedel-Crafts Acylation Reaction of an Aromatic Natural Product “Ar-Himachalene” over Nanostructured ZnO as a New Catalyst

We describe the development of a sustainable and solventless acylation reaction of the naturally occurring product, namely 2,5,9,9-tetramethyl-6,7,8,9-tetrahydro-5H-benzocycloheptene [ar-himachalene], with acid chlorides over a new type of flower-shaped ZnO nanosructure as a hetrogenous catalyst at room temperature. The ZnO nanoflowers can efficiently and selectively catalyze the acylation of the aromatic group of ar-himachalene and be reused up to three times by simple filtration and washing without significant loss in their catalytic activity. Keywords: Acylation, Natural product, Solventless, Zin Oxide nanostructure, Heterogenous Catalysis, Sustainability

(S)-4-(2-Chloro­propan-2-yl)-1-(2,2,2-trichloro­eth­yl)cyclo­hexene

The title compound, C11H16Cl4, was synthesized by the reaction of (1S)-β-pinene with triethyl­amine in the presence of ZnCl2. The cyclo­hexene ring assumes a half-boat conformation. The crystal packing is governed only by van der Waals inter­actions. The structure, which has been refined in P21, presents a striking P21/m pseudosymmetry

Natural Hydroxyapatite Ca5(PO4)3OH: An Efficient Catalyst for the Chemo- and Regioselective Enamination of the β-Ketoesters

Hydroxylapatite or hydroxyapatite Ca5(PO4)3OH (Hap), a natural mineral species of the family of phosphate, efficiently catalyzed the condensation of 1,3-ketoesters with primary amines under solvent-free conditions. The reaction was complete in 10 min, to afford β-enamino esters in a high yield and good selectivity. Moreover, the catalyst can be re-used for four times with good activities

One-Pot Transformation of Olefins into -Aminoalcohols Via Vic- Bromohydrins Catalyzed by Silica

Commercially available silica (SiO2) was found to be highly effective catalyst for one-pot synthesis of a-aminoalcohols from olefins via bromohydrins using morpholine as nitrogen fragment donor. Furthermore, silica in the presence of easily accessible N-bromosuccimide (NBS) catalyzes a rapid and quantitative room temperature bromohydroxylation of simple olefins. Various olefins are easily converted to the corresponding vic-bromohydrins and in “one pot†to a-aminoalcohols in excellent yields and high selectivity. The reaction offers a simple and efficient method for the preparation of vic-bromohydrins and a-aminoalcohools

2-(Naphthalen-1-yl­amino)­cyclo­hexa­nol

The title compound, C16H19NO, was synthesized under solvent-free conditions by reaction of 7-oxa-bicyclo­[4.1.0]heptane and naphthalen-1-amine in the presence of Ca(CF3COO)2 as catalyst. The cyclo­hexane ring adopts a chair conformation. In the crystal, mol­ecules are linked by inter­molecular N—H⋯O hydrogen bonds and C—H⋯π inter­actions into chains parallel to the c axis

[(1R,4S)-(+)-3-Benzoyl-1,7,7-trimethyl­bicyclo­[2.2.1]heptan-2-olato-κ2 O 2,O 3](η4-norbornadiene)rhodium(I)

In the title complex mol­ecule, [Rh(C17H19O2)(C7H8)], the rhodium(I) metal centre is coordinated by the O atoms of a benzoyl­camphorate anion and the C=C bonds of the norbornadiene mol­ecule into a slightly distorted square-planar coordination geometry. The six-membered chelate ring is essentially planar (r.m.s. deviation = 0.0378 Å) and forms a dihedral angle of 31.67 (11)° with the phenyl ring

Implementation of an Affordable Method for MPS Diagnosis from Urine Screening to Enzymatic Confirmation: Results of a Pilot Study in Morocco

Background: Rapid and accurate diagnosis of mucopolysaccharidoses (MPS) is still a challenge due to poor access to screening and diagnostic methods and to their extensive clinical heterogeneity. The aim of this work is to perform laboratory biochemical testing for confirming the diagnosis of mucopolysaccharidosis (MPS) for the first time in Morocco. Methods: Over a period of twelve months, 88 patients suspected of having Mucopolysaccharidosis (MPS) were referred to our laboratory. Quantitative and qualitative urine glycosaminoglycan (GAG) analyses were performed, and enzyme activity was assayed on dried blood spots (DBS) using fluorogenic substrates. Enzyme activity was measured as normal, low, or undetectable. Results: Of the 88 patients studied, 26 were confirmed to have MPS; 19 MPS I (Hurler syndrome; OMIM #607014/Hurler-Scheie syndrome; OMIM #607015), 2 MPS II (Hunter syndrome; OMIM #309900), 2 MPS IIIA (Sanfilippo syndrome; OMIM #252900), 1 MPS IIIB (Sanfilippo syndrome; OMIM #252920) and 2 MPS VI (Maroteaux-Lamy syndrome; OMIM #253200). Parental consanguinity was present in 80.76% of cases. Qualitative urinary glycosaminoglycan (uGAGs) assays showed abnormal profiles in 31 cases, and further quantitative urinary GAG evaluation and Thin Layer Chromatography (TLC) provided important additional information about the likely MPS diagnosis. The final diagnosis was confirmed by specific enzyme activity analysis in the DBS samples. Conclusions: The present study shows that the adoption of combined urinary substrate analysis and enzyme assays using dried blood spots can facilitate such diagnosis, offer an important tool for an appropriate supporting care, and a specific therapy, when available