Inband Relaying in Long Term Evolution-Advanced Networks

The set of stringent requirements for 4G radio access networks has triggered the embodiment of new small low-power nodes, e.g. relay, Femto and Pico access nodes, as part of the network infrastructure. Various types of relay nodes are currently supported in IEEE 802.16m and 3GPP LTE-Advanced, e.g. inband Layer 2 or Layer 3 nodes and outband nodes, considering different functional capabilities and backhauling characteristics. In general, relay nodes are characterized by compact physical characteristics, low power consumption, a wireless backhaul link to the core network, and relaxed installation guidelines with respect to radiation and planning regulation. In specific, inband relay nodes, the matter of this study, are Layer 3 access nodes with time-multiplexed transmission and reception on their wireless backhaul and access links, which operate on the same frequency band. These characteristics impose serious challenges on one hand, but allow for significant improvements on the other hand. In this context, the deployment flexibility of relay nodes simplifies the network planning procedure and reduces deployment costs. On the other hand, low power transmission and limited antenna capabilities result in small relay cell coverage areas which will lead to load imbalances. Besides, multiplexing backhaul and access communications on different subframes implies the need for suitable two-hop resource allocation and scheduling. Further challenges are attributed to increased interference levels compared to macrocell deployments, as well as the introduction of a new interference type known as relay-to-relay interference resulting from the misalignment of access and backhaul link dedicated subframes at different relay nodes. The research towards this thesis has addressed these challenges within 3GPP LTE-Advanced context. A feasibility study of different relaying modes is provided and the performance of relay deployments is evaluated in different propagation environments. Thereafter, simple network planning techniques are proposed to alleviate the limitations of the inband backhaul link. Further, novel techniques are investigated to address resource allocation and scheduling, load balancing and interference coordination. The performance of proposed techniques along with the energy efficiency of relay nodes is evaluated. Results show in general significant gains and validate relaying as an efficient enhancement technology

Group Validation in Recommender Systems: Framework for Multi-layer Performance Evaluation

Interpreting the performance results of models that attempt to realize user behavior in platforms that employ recommenders is a big challenge that researchers and practitioners continue to face. Although current evaluation tools possess the capacity to provide solid general overview of a system's performance, they still lack consistency and effectiveness in their use as evident in most recent studies on the topic. Current traditional assessment techniques tend to fail to detect variations that could occur on smaller subsets of the data and lack the ability to explain how such variations affect the overall performance. In this article, we focus on the concept of data clustering for evaluation in recommenders and apply a neighborhood assessment method for the datasets of recommender system applications. This new method, named neighborhood-based evaluation, aids in better understanding critical performance variations in more compact subsets of the system to help spot weaknesses where such variations generally go unnoticed with conventional metrics and are typically averaged out. This new modular evaluation layer complements the existing assessment mechanisms and provides the possibility of several applications to the recommender ecosystem such as model evolution tests, fraud/attack detection and a possibility for hosting a hybrid model setup

The Functionality of the three-sited Ferroxidase center of E. coli Bacterial Ferritin (EcFtnA)

At least three ferritins are found in the bacterium Escherichia coli, the heme-containing bacterioferritin (EcBFR) and two non-heme bacterial ferritins (EcFtnA and EcFtnB). In addition to the conserved A- and B-sites of the diiron ferroxidase center, EcFtnA has a third iron-binding site (the C-site) of unknown function that is nearby the diiron site. In the present work, the complex chemistry of iron oxidation and deposition in EcFtnA has been further defined through a combination of oximetry, pH stat, stopped-flow and conventional kinetics, UV-visible, fluorescence and EPR spectroscopic measurements on the wildtype protein and site-directed variants of the A-, B- and C-sites. The data reveal that, while H2O2 is a product of dioxygen reduction in EcFtnA and oxidation occurs with a stoichiometry of Fe(II)/O2 ~ 3:1, most of the H2O2 produced is consumed in subsequent reactions with a 2:1 Fe(II)/H2O2 stoichiometry, thus suppressing hydroxyl radical formation. While the A- and B-sites are essential for rapid iron oxidation, the C-site slows oxidation and suppresses iron turnover at the ferroxidase center. A tyrosyl radical, assigned to Tyr24 near the ferroxidase center, is formed during iron oxidation and its possible significance to the function of the protein is discussed. Taken as a whole, the data indicate that there are multiple iron-oxidation pathways in EcFtnA with O2 and H2O2 as oxidants. Furthermore, the data are inconsistent with the C-site being a transit site, providing iron to the A- and B-sites, and does not support a universal mechanism for iron oxidation in all ferritins as recently proposed

Chemically and Biologically Harmless versus Harmful Ferritin/Copper–Metallothionein Couples

"This is the peer reviewed version of the following article: Carmona Rodríguez-Acosta, F.; et al. Chemically and Biologically Harmless versus Harmful Ferritin/Copper–Metallothionein Couples. Chemistry A European Journal, 21(2): 808-813 (2015), which has been published in final form at http://dx.doi.org/10.1002/chem.201404660. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."The simultaneous measurement of the decrease of available FeII ions and the increase of available FeIII ions allowed the analysis of the ferroxidase activity of two distinct apoferritins. Although recombinant human apoferritin (HuFtH) rapidly oxidizes FeII to FeIII, this iron is not properly stored in the ferritin cavity, as otherwise occurs in horse-spleen H/L-apoferritin (HsFt; H=heavy subunit, L=light subunit). Iron storage in these apoferritins was also studied in the presence of two copper-loaded mammalian metallothioneins (MT2 and MT3), a scenario that occurs in different brain-cell types. For HuFtH, unstored FeIII ions trigger the oxidation of Cu–MT2 with concomitant CuI release. In contrast, there is no reaction with Cu–MT2 in the case of HsFt. Similarly, Cu–MT3 does not react during either HuFtH or HsFt iron reconstitution. Significantly, the combination of ferritin and metallothionein isoforms reported in glia and neuronal cells are precisely those combinations that avoid a harmful release of FeII and CuI ions.Work supported by the Spanish MINECO and FEDER funds with grants CTQ2012–32236 to J.M.D.-V., BIO2012–39682-C02–01 to S.A., and BIO2012–39682-C02–02 to M.C. The authors from the Barcelona universities are members of the Grup de Recerca de la Generalitat de Catalunya (refs. 2014SGR-00423). F.C. is grateful to the Spanish MINECO for a FPI Fellowship

EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON DISTRACTION OSTEOGENESIS IN THE MANDIBLE OF RABBITS: A MORPHOLOGIC AND MORPHOMETRIC APPROACH

Distraction osteogenesis of the jaws is a common surgical practice in the treatment of pediatric craniofacial deformities. Autologous platelet rich plasma (PRP) has been used to increase the healing potential of bones in humans during distraction osteogenesis. This article aims to study the morphometric and morphologic parameters resulting from the effect of PRP on bone healing after mandibular distraction in rabbits. Right mandibular distraction was performed in 12 rabbits divided equally into 2 groups. PRP and physiological saline were injected, according to a defined protocol, in the callus following distraction of the experimental and control groups respectively. The rabbits were sacrificed after a consolidation period of 45 days and the mandibles were surgically removed. Bone mineral density, radiographic analysis, mechanical properties and histological features of the lengthened bones were assessed using radiographic examination, dual X-ray absorptiometry, biomechanical testing and histology. Results showed that the regenerate bone density, the amount of trabeculation in addition to the bone mineral density and mineral content, as measured by absorptiometry, were better with PRP but not significantly different between groups. Two radiographs revealed a more consistent healing in the experimental mandibles compared with erratic outcomes in corresponding controls. Two of the latter could not be subjected to any mechanical testing because the mandibular parts, connected with fibrous tissue, were separated. Consequently, the biomechanical test depicted greater maximal loads in the experimental group. The histological studies exhibited more ossification and less connective tissue fibers in the experimental group. PRP accelerated healing of mandibles in rabbits following distraction and improved their biomechanical properties. These findings have significant clinical implications on reducing the period of consolidation of the mandibles which may not be immobilized like other bones for long period tim