9,162 research outputs found
Incompressible viscous flow near the leading edge of a flat plate admitting slip
The shear stress at the leading edge, calculated on basis of the Navier-Stokes equations and the no-slip boundary condition, approaches infinity. However, taking into account the mean free path of the molecules, which implies admitting a certain slip, the shear stress becomes inversely proportional to the square root of the Knudsen number κ if κ→0. κ is defined as the ratio between the mean free path and the viscous length. The new boundary condition modifies the shear stress only within the Knudsen region of which the size is of the order of 3 to 4 times the mean free path.
Accuracy Characterization of a MEMS Accelerometer for Vibration Monitoring in a Rotating Framework
Active and passive vibration control systems are of paramount importance in many engineering applications. If an external load excites a structure’s resonance and the damping is too low, detrimental events, such as crack initiation, growth and, in the worst case, fatigue failure, can be entailed. Damping systems can be commonly found in applications such as industrial machines, vehicles, buildings, turbomachinery blades, and so forth. Active control systems usually achieve higher damping effectiveness than passive ones, but they need a sensor to detect the working conditions that require damping system activation. Recently, the development of such systems in rotating structures has received considerable interest among designers. As a result, the development of vibration monitoring equipment in rotating structures is also a topic of particular interest. In this respect, a reliable, inexpensive and wireless monitoring system is of utmost importance. Typically, optical systems are used to measure vibrations, but they are expensive and require rather complex processing algorithms. In this paper, a wireless system based on a commercial MEMS accelerometer is developed for rotating blade vibration monitoring. The proposed system measurement accuracy was assessed by means of comparison with a reference wired measurement setup based on a mini integrated circuit piezoelectric (ICP) accelerometer adapted for data acquisition in a rotating frame. Both the accelerometers were mounted on the tip of the blade and, in order to test the structure under different conditions, the first four blade resonances were excited by means of piezoelectric actuators, embedded in a novel experimental setup. The frequency and amplitude of acceleration, simultaneously measured by the reference and MEMS sensors, were compared with each other in order to investigate the viability and accuracy of the proposed wireless monitoring system. The rotor angular speed was varied from 0 to 300 rpm, and the data acquisitions were repeated six times for each considered condition. The outcomes reveal that the wireless measurement system may be successfully used for vibration monitoring in rotating blades
High spin Fe(III)-doped nanostructures as T1 MR imaging probes
Magnetic Resonance Imaging (MRI) T1 contrast agents based on Fe(III) as an alternative to Gd-based compounds have been under intense scrutiny in the last 6-8 years and a number of nanostructures have been designed and proposed for in vivo diagnostic and theranostic applications. Excluding the large family of superparamagnetic iron oxides widely used as T2 -MR imaging agents that will not be covered by this review, a considerable number and type of nanoparticles (NPs) have been employed, ranging from amphiphilic polymer-based NPs, NPs containing polyphenolic binding units such as melanin-like or polycatechols, mixed metals such as Fe/Gd or Fe/Au NPs and perfluorocarbon nanoemulsions. Iron(III) exhibits several favorable magnetic properties, high biocompatibility and improved toxicity profile that place it as the paramagnetic ion of choice for the next generation of nanosized MRI and theranostic contrast agents. An analysis of the examples reported in the last decade will show the opportunities for relaxivity and MR-contrast enhancement optimization that could bring Fe(III)-doped NPs to really compete with Gd(III)-based nanosystems. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Diagnostic Tools > Diagnostic Nanodevices Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
An updated checklist and biogeography of the Sardinian large branchiopods, with a focus on Spinicaudata (Crustacea, Branchiopoda)
The large branchiopod fauna of Sardinia is reviewed based both on literature and newly collected data. Based on the available evidence, 13 taxa are present on the island (8 Anostraca, 2 Notostraca, and 3 Spinicaudata). Among them, the finding of the spinicaudatan Leptestheria dahalacensis is new for Sardinia, while the spinicaudatans Cyzicus bucheti and Eulimnadia sp. were overlooked in the most recent synopses on the fauna of the island due to misidentifications. Conversely, Cyzicus tetracerus and Limnadia lenticularis, previously erroneously reported based on misidentifications, must be excluded from the fauna of Sardinia. The finding of Eulimnadia sp. is the first record in Europe and the northernmost record of the genus. The occurrence of Leptestheria dahalacensis in Sardinia is rather unexpected and probably due to its accidental introduction linked with rice cultures. At least four of the 13 Sardinian large branchiopod species are absent from the Italian mainland and Sicily, stressing the uniqueness of its fauna and its significant contribution to the Mediterranean inland water crustacean diversity
Use of biochar as filler for biocomposite blown films: Structure-processing-properties relationships
In this work, biocomposite blown films based on poly(butylene adipate-co-terephthalate) (PBAT) as biopolymeric matrix and biochar (BC) as filler were successfully fabricated. The materials were subjected to a film-blowing process after being compounded in a twin-screw extruder. The preliminary investigations conducted on melt-mixed PBAT/BC composites allowed PBAT/BC 5% and PBAT/BC 10% to be identified as the most appropriate formulations to be processed via film blowing. The blown films exhibited mechanical performances adequate for possible application as film for packaging, agricultural, and compost bags. The addition of BC led to an improvement of the elastic modulus, still maintaining high values of deformation. Water contact angle measurements revealed an increase in the hydrophobic behavior of the biocomposite films compared to PBAT. Additionally, accelerated degradative tests monitored by tensile tests and spectroscopic analysis revealed that the filler induced a photo-oxidative resistance on PBAT by delaying the degradation phenomena
Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study
Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating levels are significantly associated with an increased risk of cardiovascular events. This study aimed to evaluate the relationship between circulating levels of PCSK9 and arterial stiffness, an early instrumental biomarker of cardiovascular disease risk, in a large sample of overall healthy participants
Bionanocomposite blown films: Insights on the rheological and mechanical behavior
In this work, bionanocomposites based on two different types of biopolymers belonging to the MaterBi® family and containing two kinds of modified nanoclays were compounded in a twinscrew extruder and then subjected to a film blowing process, aiming at obtaining sustainable films potentially suitable for packaging applications. The preliminary characterization of the extruded bionanocomposites allowed establishing some correlations between the obtained morphology and the material rheological and mechanical behavior. More specifically, the morphological analysis showed that, regardless of the type of biopolymeric matrix, a homogeneous nanofiller dispersion was achieved; furthermore, the established biopolymer/nanofiller interactions caused a restrain of the dynamics of the biopolymer chains, thus inducing a significant modification of the material rheological response, which involves the appearance of an apparent yield stress and the amplification of the elastic feature of the viscoelastic behavior. Besides, the rheological characterization under non-isothermal elongational flow revealed a marginal effect of the embedded nanofillers on the biopolymers behavior, thus indicating their suitability for film blowing processing. Additionally, the processing behavior of the bionanocomposites was evaluated and compared to that of similar systems based on a low-density polyethylene matrix: this way, it was possible to identify the most suitable materials for film blowing operations. Finally, the assessment of the mechanical properties of the produced blown films documented the potential exploitation of the selected materials for packaging applications, also at an industrial level
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.
he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates. We previously reported a set of substituted 1,5-diarylpyrrole derivatives, along with their inhibitory activity toward COX enzymes. Several compounds proved to be highly selective COX-2 inhibitors and their affinity data were rationalized through docking simulations. In this paper, we describe the synthesis of new 1,5-diarylpyrrole derivatives that were assayed for their in vitro inhibitory effects toward COX isozymes. Among them, the ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-fluorophenyl]-1H-pyrrol-3- acetate (1d), which was the most potent and COX-2 selective compound, also showed a very interesting in vivo anti-inflammatory and analgesic activity, laying the foundations for developing new lead compounds that could be effective agents in the armamentarium for the management of inflammation and pain
Biochar Particles Obtained from Agricultural Carob Waste as a Suitable Filler for Sustainable Biocomposite Formulations
In the context of sustainable and circular economy, the recovery of biowaste for sustainable biocomposites formulation is a challenging issue. The aim of this work is to give a new life to agricultural carob waste after glucose extraction carried out by a local factory for carob candy production. A pyrolysis process was carried out on bio-waste to produce biofuel and, later, the solid residual fraction of pyrolysis process was used as interesting filler for biocomposites production. In this work, biochar particles (BC) as a pyrolysis product, after fuels recovery of organic biowaste, specifically, pyrolyzed carobs after glucose extraction, were added on poly(butylene-adipate-co-terephthalate), (PBAT), at two different concentrations, i.e., 10 and 20 wt%. The BC have been produced using three pyrolysis processing temperatures (i.e., 280, 340 and 400 degrees C) to optimize the compositions of produced solid fractions and biofuels. The resulting particles from the pyrolysis process (BC280, BC340 and BC400) were considered as suitable fillers for PBAT. Firstly, the BC particles properties were characterized by elemental composition and spectroscopy analysis, particle size measurements and evaluation of radical scavenging activity and efficiency. Moreover, PBAT/BC composites were subjected to analysis of their rheological and thermal behavior, morphologies and mechanical properties. In addition, accelerated weathering, monitored by both tensile test and spectroscopic analysis, was carried out, and obtained results show that the biochar particles can exert a beneficial effect on photo-oxidation delay of PBAT matrix
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