Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration

Spatiotemporal expression patterns of six members of the Eph gene family (EphA4, EphA3, EphB2, ephrin-B1, ephrin-A2, and ephrin-A5) were characterized immunocytochemically at various stages of chick cerebellar development. EphA4 expression is observed in the cerebellar anlage as early as embryonic day 5 (E5) and continues in the posthatch cerebellum. During the early period of cerebellar development (E3-E8), complementarity is observed between EphA4 and ephrin-A5 expression within the cerebellar-isthmal region. By E8, differential expression of EphA4 in parasagittal Purkinje cell bands is evident, and the expression remains banded in the posthatch cerebellum. Banded expression of the ephrin-A5 ligand complements EphA4 expression during the middle period (E9-E15). During this period, ephrin-A2 and EphA3 are coexpressed in a banded pattern and with variable correlation to EphA4. Variability in the banding expression is observed for EphA4, EphA3, ephrin-A5, and ephrin-A2 across different lobes, and graded complementarity in the expression pattern of EphA3 and ephrin-A5 is observed in the external granular layer between the posterior and anterior lobes. Analysis of Purkinje cell birth date in correlation with Eph-ephrin expression during the middle period reveals that early-born cells express EphA4, whereas late-born cells express ephrin-A5. Finally, EphA4 expression domains are respected by migrating granule cell ribbons, which express both ephrin-B1 and EphB2. These expression patterns suggest multiple roles for the Eph-ephrin system in cerebellar development, including demarcation/enforcement of boundaries of the cerebellar anlage, formation/maintenance of Purkinje cell compartments, and restriction of the early phase of granule cell migration to ribbons

Royal endowment of peerage creations in the reign of Edward III

This thesis is an examination of the use Edward III made of various resources at his disposal in order to patronize a number of individuals destined for the parliamentary peerage or beyond. Primarily through a judicious use of escheats, forfeitures and expectancies, though also through his control over the marriages of his tenants-in-chief, Edward managed to endow a considerable number of new men with properties both suitable to their existing estates and commensurate with their new ranks. Edward's use of these sources, along with temporary forms of patronage such as wardships, annuities, offices and smaller token forms of favour, unsurprisingly sparked a considerable amount of contemporary reaction. However, unlike previous favourites, though Edward's new men did have to contend with a substantial amount of opposition at an individual level - especially in the law courts - popular reaction in general was surprisingly mute. Though there were instances when these men were singled out for criticism, for the most part landed society as a whole, and the established nobility in particular, received them with a degree of toleration rarely exhibited to parvenus. In part due to Edward's use of propaganda, but also to the terms on which he granted out a large portion of the patronage, Edward's new creations were seen as complementing rather than threatening the existing order. Indeed, it was Edward himself who may be said to have limited the powers of his 'new nobility' not only by making them dependent on his goodwill, but also by not allowing for much of the patronage granted out to remain out indefinitely. In the end, then, this thesis is about the first coherent realization by an English monarch of the importance of controlling the composition of the parliamentary peerage at a time when its membership was becoming increasingly predetermined

SPT 0538–50: Physical Conditions in the Interstellar Medium of a Strongly Lensed Dusty Star-forming Galaxy at z = 2.8

We present observations of SPT-S J053816–5030.8, a gravitationally lensed dusty star-forming galaxy (DSFG) at z = 2.7817 that was first discovered at millimeter wavelengths by the South Pole Telescope. SPT 0538–50 is typical of the brightest sources found by wide-field millimeter-wavelength surveys, being lensed by an intervening galaxy at moderate redshift (in this instance, at z = 0.441). We present a wide array of multi-wavelength spectroscopic and photometric data on SPT 0538–50, including data from ALMA, Herschel PACS and SPIRE, Hubble, Spitzer, the Very Large Telescope, ATCA, APEX, and the Submillimeter Array. We use high-resolution imaging from the Hubble Space Telescope to de-blend SPT 0538–50, separating DSFG emission from that of the foreground lens. Combined with a source model derived from ALMA imaging (which suggests a magnification factor of 21 ± 4), we derive the intrinsic properties of SPT 0538–50, including the stellar mass, far-IR luminosity, star formation rate, molecular gas mass, and—using molecular line fluxes—the excitation conditions within the interstellar medium. The derived physical properties argue that we are witnessing compact, merger-driven star formation in SPT 0538–50 similar to local starburst galaxies and unlike that seen in some other DSFGs at this epoch

The development and evaluation of exercises for meaningful responses in reading in grade two

Research chapter for this study will be found in Ash, Dorothea: "Development and evaluation of silent reading exercises in grade one" Thesis (M.A.)--Boston Universit

Auto-immune haematological complications occurring during the treatment of malignant lymphoproliferative diseases

Auto-immune haematological complications occurring during treatment for malignant Iymphoproliferative diseases are described in 5 patients. There appeared to be a temporal relationship between the development of these complications and the administration of chemotherapeutic drugs or extensive radiotherapy.S. Afr. Med. J., 48, 2143 (1974)

ALLSMOG: an APEX Low-redshift Legacy Survey for MOlecular Gas. I - molecular gas scaling relations, and the effect of the CO/H2 conversion factor

We present ALLSMOG, the APEX Low-redshift Legacy Survey for MOlecular Gas. ALLSMOG is a survey designed to observe the CO(2-1) emission line with the APEX telescope, in a sample of local galaxies (0.01 < z < 0.03), with stellar masses in the range 8.5 < log(M*/Msun) < 10. This paper is a data release and initial analysis of the first two semesters of observations, consisting of 42 galaxies observed in CO(2-1). By combining these new CO(2-1) emission line data with archival HI data and SDSS optical spectroscopy, we compile a sample of low-mass galaxies with well defined molecular gas masses, atomic gas masses, and gas-phase metallicities. We explore scaling relations of gas fraction and gas consumption timescale, and test the extent to which our findings are dependent on a varying CO/H2 conversion factor. We find an increase in the H2/HI mass ratio with stellar mass which closely matches semi-analytic predictions. We find a mean molecular gas fraction for ALLSMOG galaxies of MH2/M* = (0.09 - 0.13), which decreases with stellar mass. We measure a mean molecular gas consumption timescale for ALLSMOG galaxies of 0.4 - 0.7 Gyr. We also confirm the non-universality of the molecular gas consumption timescale, which varies (with stellar mass) from ~100 Myr to ~2 Gyr. Importantly, we find that the trends in the H2/HI mass ratio, gas fraction, and the non-universal molecular gas consumption timescale are all robust to a range of recent metallicity-dependent CO/H2 conversion factors.Comment: 25 pages, 15 figures. Accepted for publication in MNRA

Molecular gas as the driver of fundamental galactic relations

There has been much recent work dedicated to exploring secondary correlations in the mass-metallicity relation, with significant dependence on both the SFR (SFR) and Hi content being demonstrated. Previously, a paucity of molecular gas data (combined with sample selection bias) hampered the investigation of any such relation with molecular gas content. In this work, we assemble a sample of 221 galaxies from a variety of surveys in the redshift range 0<z<2, to explore the connection between molecular gas content and metallicity. We explore the effect of gas mass on the mass-metallicity relation, finding that the offset from the relation is negatively correlated against both molecular and total gas mass. We then employ a principle component analysis technique to explore secondary dependences in the mass-metallicity relation, finding that the secondary dependence with gas mass is significantly stronger than with SFR, and as such the underlying ‘fundamental metallicity relation' is between stellar mass, metallicity, and gas mass. In particular, the metallicity dependence on SFR is simply a byproduct of the dependence on the molecular gas content, via the Schmidt-Kennicutt relation. Finally, we note that our principle component analysis finds essentially no connection between gas-phase metallicity and the efficiency of star formatio