748 research outputs found
Mass-independent scheme for enhancing spatial quantum superpositions
Placing a large mass in a large spatial superposition, such as a Schrödinger cat state, is a significant and important challenge. In particular, the large spatial superposition [O(10-100)μm] of mesoscopic masses [m∼O(10-14-10-15)kg] makes it possible to test the quantum nature of gravity via entanglement in the laboratory. To date, the proposed methods of achieving this spatial delocalization are to use wave-packet expansions or quantum ancilla- (for example, spin-) dependent forces, all of whose efficacy reduces with mass. Thus increasing the spatial splitting independently of the mass is an important open challenge. In this paper we present a method of achieving a mass-independent enhancement of superposition via diamagnetic repulsion from current-carrying wires. We analyze an example system which uses the Stern-Gerlach effect to creating a small initial splitting and then apply our diamagnetic repulsion method to enhance the superposition size O(400-600)μm from an initial modest split of the wave function. We provide an analytical and numerical analysis of our scheme
Relative Acceleration Noise Mitigation for Nanocrystal Matter-wave Interferometry: Application to Entangling Masses via Quantum Gravity
Matter wave interferometers with large momentum transfers, irrespective of specific implementations, will face a universal dephasing due to relative accelerations between the interferometric mass and the associated apparatus. Here we propose a solution that works even without actively tracking the relative accelerations: putting both the interfering mass and its associated apparatus in a freely falling capsule, so that the strongest inertial noise components vanish due to the equivalence principle. In this setting, we investigate two of the most important remaining noise sources: (a) the non-inertial jitter of the experimental setup and (b) the gravity-gradient noise. We show that the former can be reduced below desired values by appropriate pressures and temperatures, while the latter can be fully mitigated in a controlled environment. We finally apply the analysis to a recent proposal for testing the quantum nature of gravity [S. Bose et. al. Phys. Rev. Lett 119, 240401 (2017)] through the entanglement of two masses undergoing interferometry. We show that the relevant entanglement witnessing is feasible with achievable levels of relative acceleration noise
The Complexity of Drawing Graphs on Few Lines and Few Planes
It is well known that any graph admits a crossing-free straight-line drawing
in and that any planar graph admits the same even in
. For a graph and , let denote
the minimum number of lines in that together can cover all edges
of a drawing of . For , must be planar. We investigate the
complexity of computing these parameters and obtain the following hardness and
algorithmic results.
- For , we prove that deciding whether for a
given graph and integer is -complete.
- Since , deciding is NP-hard for . On the positive side, we show that the problem
is fixed-parameter tractable with respect to .
- Since , both and
are computable in polynomial space. On the negative side, we show
that drawings that are optimal with respect to or
sometimes require irrational coordinates.
- Let be the minimum number of planes in needed
to cover a straight-line drawing of a graph . We prove that deciding whether
is NP-hard for any fixed . Hence, the problem is
not fixed-parameter tractable with respect to unless
U.S. Physicians’ Views on Financing Options to Expand Health Insurance Coverage: A National Survey
Background: Physician opinion can influence the prospects for health care reform, yet there are few recent data on physician views on reform proposals or access to medical care in the United States. Objective: To assess physician views on financing options for expanding health care coverage and on access to health care. Design and Participants: Nationally representative mail survey conducted between March 2007 and October 2007 of U.S. physicians engaged in direct patient care. Measurements: Rated support for reform options including financial incentives to induce individuals to purchase health insurance and single-payer national health insurance; rated views of several dimensions of access to care. Main results: 1,675 of 3,300 physicians responded (50.8%). Only 9% of physicians preferred the current employer-based financing system. Forty-nine percent favored either tax incentives or penalties to encourage the purchase of medical insurance, and 42% preferred a government-run, taxpayer-financed single-payer national health insurance program. The majority of respondents believed that all Americans should receive needed medical care regardless of ability to pay (89%); 33% believed that the uninsured currently have access to needed care. Nearly one fifth of respondents (19.3%) believed that even the insured lack access to needed care. Views about access were independently associated with support for single-payer national health insurance. Conclusions: The vast majority of physicians surveyed supported a change in the health care financing system. While a plurality support the use of financial incentives, a substantial proportion support single payer national health insurance. These findings challenge the perception that fundamental restructuring of the U.S. health care financing system receives little acceptance by physicians
Heterogeneous Response to a Quorum-Sensing Signal in the Luminescence of Individual Vibrio fischeri
The marine bacterium Vibrio fischeri regulates its bioluminescence through a quorum sensing mechanism: the bacterium releases diffusible small molecules (autoinducers) that accumulate in the environment as the population density increases. This accumulation of autoinducer (AI) eventually activates transcriptional regulators for bioluminescence as well as host colonization behaviors. Although V.fischeri quorum sensing has been extensively characterized in bulk populations, far less is known about how it performs at the level of the individual cell, where biochemical noise is likely to limit the precision of luminescence regulation. We have measured the time-dependence and AI-dependence of light production by individual V.fischeri cells that are immobilized in a perfusion chamber and supplied with a defined concentration of exogenous AI. We use low-light level microscopy to record and quantify the photon emission from the cells over periods of several hours as they respond to the introduction of AI. We observe an extremely heterogeneous response to the AI signal. Individual cells differ widely in the onset time for their luminescence and in their resulting brightness, even in the presence of high AI concentrations that saturate the light output from a bulk population. The observed heterogeneity shows that although a given concentration of quorum signal may determine the average light output from a population of cells, it provides far weaker control over the luminescence output of each individual cell
Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction (EXAMI): study protocol for a randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Myocardial infarction causes irreversible loss of cardiomyocytes and may lead to loss of ventricular function, morbidity and mortality. Infarct size is a major prognostic factor and reduction of infarct size has therefore been an important objective of strategies to improve outcomes. In experimental studies, glucagon-like peptide 1 and exenatide, a long acting glucagon-like peptide 1 receptor agonist, a novel drug introduced for the treatment of type 2 diabetes, reduced infarct size after myocardial infarction by activating pro-survival pathways and by increasing metabolic efficiency.</p> <p>Methods</p> <p>The EXAMI trial is a multi-center, prospective, randomized, placebo controlled trial, designed to evaluate clinical outcome of exenatide infusion on top of standard treatment, in patients with an acute myocardial infarction, successfully treated with primary percutaneous coronary intervention. A total of 108 patients will be randomized to exenatide (5 μg bolus in 30 minutes followed by continuous infusion of 20 μg/24 h for 72 h) or placebo treatment. The primary end point of the study is myocardial infarct size (measured using magnetic resonance imaging with delayed enhancement at 4 months) as a percentage of the area at risk (measured using T2 weighted images at 3-7 days).</p> <p>Discussion</p> <p>If the current study demonstrates cardioprotective effects, exenatide may constitute a novel therapeutic option to reduce infarct size and preserve cardiac function in adjunction to reperfusion therapy in patients with acute myocardial infarction.</p> <p>Trial registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01254123">NCT01254123</a></p
Albiglutide, a Long Lasting Glucagon-Like Peptide-1 Analog, Protects the Rat Heart against Ischemia/Reperfusion Injury: Evidence for Improving Cardiac Metabolic Efficiency
BACKGROUND: The cardioprotective effects of glucagon-like peptide-1 (GLP-1) and analogs have been previously reported. We tested the hypothesis that albiglutide, a novel long half-life analog of GLP-1, may protect the heart against I/R injury by increasing carbohydrate utilization and improving cardiac energetic efficiency. METHODS/PRINCIPAL FINDINGS: Sprague-Dawley rats were treated with albiglutide and subjected to 30 min myocardial ischemia followed by 24 h reperfusion. Left ventricle infarct size, hemodynamics, function and energetics were determined. In addition, cardiac glucose disposal, carbohydrate metabolism and metabolic gene expression were assessed. Albiglutide significantly reduced infarct size and concomitantly improved post-ischemic hemodynamics, cardiac function and energetic parameters. Albiglutide markedly increased both in vivo and ex vivo cardiac glucose uptake while reducing lactate efflux. Analysis of metabolic substrate utilization directly in the heart showed that albiglutide increased the relative carbohydrate versus fat oxidation which in part was due to an increase in both glucose and lactate oxidation. Metabolic gene expression analysis indicated upregulation of key glucose metabolism genes in the non-ischemic myocardium by albiglutide. CONCLUSION/SIGNIFICANCE: Albiglutide reduced myocardial infarct size and improved cardiac function and energetics following myocardial I/R injury. The observed benefits were associated with enhanced myocardial glucose uptake and a shift toward a more energetically favorable substrate metabolism by increasing both glucose and lactate oxidation. These findings suggest that albiglutide may have direct therapeutic potential for improving cardiac energetics and function
Observation of strong coupling between a micromechanical resonator and an optical cavity field
Achieving coherent quantum control over massive mechanical resonators is a
current research goal. Nano- and micromechanical devices can be coupled to a
variety of systems, for example to single electrons by electrostatic or
magnetic coupling, and to photons by radiation pressure or optical dipole
forces. So far, all such experiments have operated in a regime of weak
coupling, in which reversible energy exchange between the mechanical device and
its coupled partner is suppressed by fast decoherence of the individual systems
to their local environments. Controlled quantum experiments are in principle
not possible in such a regime, but instead require strong coupling. So far,
this has been demonstrated only between microscopic quantum systems, such as
atoms and photons (in the context of cavity quantum electrodynamics) or solid
state qubits and photons. Strong coupling is an essential requirement for the
preparation of mechanical quantum states, such as squeezed or entangled states,
and also for using mechanical resonators in the context of quantum information
processing, for example, as quantum transducers. Here we report the observation
of optomechanical normal mode splitting, which provides unambiguous evidence
for strong coupling of cavity photons to a mechanical resonator. This paves the
way towards full quantum optical control of nano- and micromechanical devices.Comment: Published versio
Ratio of the Isolated Photon Cross Sections at \sqrt{s} = 630 and 1800 GeV
The inclusive cross section for production of isolated photons has been
measured in \pbarp collisions at GeV with the \D0 detector at
the Fermilab Tevatron Collider. The photons span a transverse energy ()
range from 7-49 GeV and have pseudorapidity . This measurement is
combined with to previous \D0 result at GeV to form a ratio
of the cross sections. Comparison of next-to-leading order QCD with the
measured cross section at 630 GeV and ratio of cross sections show satisfactory
agreement in most of the range.Comment: 7 pages. Published in Phys. Rev. Lett. 87, 251805, (2001
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