Self impedance matched Hall-effect gyrators and circulators

We present a model study of an alternative implementation of a two-port Hall-effect microwave gyrator. Our set-up involves three electrodes, one of which acts as a common ground for the others. Based on the capacitive-coupling model of Viola and DiVincenzo, we analyze the performance of the device and we predict that ideal gyration can be achieved at specific frequencies. Interestingly, the impedance of the three-terminal gyrator can be made arbitrarily small for certain coupling strengths, so that no auxiliary impedance matching is required. Although the bandwidth of the device shrinks as the impedance decreases, it can be improved by reducing the magnetic field; it can be realistically increased up to $150 \mathrm{MHz}$ at $50\mathrm{\Omega}$ by working at filling factor $\nu=10$. We examine also the effects of the parasitic capacitive coupling between electrodes and we find that, although in general they strongly influence the response of device, their effect is negligible at low impedance. Finally, we analyze an interferometric implementation of a circulator, which incorporates the gyrator in a Mach-Zender-like construction. Perfect circulation in both directions can be achieved, depending on frequency and on the details of the interferometer

Opportunities and Challenges of Sustainable Development and Digital Revolution: the Italian case of Toolery

This article explores how Digital Transformation can provide support for achieving the Sustainable Development Goals (SDGs) of the UN's 2030 Agenda. The article aims to provide a case study of the use of technology in a low-tech sector, the construction industry, in order to make the costs of reducing the positive impacts on the environment and people sustainable from an economic point of view as well. The article produces practical implications by describing strengths, weaknesses opportunities and major challenges of digital technologies for designing sustainable business models

Measuring Sustainability in the Luxury Fashion Sector: A Comparison between LVMH and Kering

New social, environmental, and economic scenarios and the continuous evolution of the business world are directing society’s attention towards sustainability. In the current market context, there is a lot of talk about Corporate Social Responsibility (CSR), the tools needed to implement it and the consequent accountability. Undertaking CSR policies is a voluntary choice and this ̀ implies that organizations need to implement a system of guidelines and internal and external processes that influence all their activities. In this regard, this work focuses on the consultation and relative analysis of the “Sustainability Progress Reports” of the global luxury groups Kering and LVMH to proceed to a subsequent analysis related to the material themes of each of the Fashion Houses

Integration of the Intellectual Capital in the Healthcare Organizations: The Case of the Lazio Region Local Health Units

Healthcare Organizations can be identified as contexts that can be defined as highly “knowledge-intensive”, both because of the peculiar characteristics of the personnel working in them, who are highly specialized, and because of the quality of the services provided. When we talk about Intellectual Capital within the Public Administration, the health sector proves to be among the least investigated, with the consequent lack of a reference model for the presentation of variables and a clear awareness of the criticalities found in the representation of this concept in such complex organizations. For this reason, the following research focuses on the content analysis of the Corporate Acts of the Lazio Region Local Health Units (ASLs) to analyse the impact of Intellectual Capital on Organization performance, specifically by resorting to key indicators identified concerning the three dimensions of Intellectual Capital (relational-individual-internal). The study aims to propose insights on IC for all public settings, both health and non-health, to integrate better the Intellectual Capital employed and help stakeholders understand the topic better

Digital Social Innovation and Sustainability: An Analysis of the Large-Scale Retailing Sector during the Covid-19 Pandemic

The following paper analyzes the Digital Social Innovation (DSI) phenomenon and focuses on why new technological trends are essential both for the country's growth and for Sustainable Development. The study conducted focused on the consequences of Covid-19 on society and sectors in Italy, analyzing how a digital response was able to positively affect the growth of the Large-Scale Retailing (LSR) sector. The ultimate goal is to understand the extent to which digitization affects economic, social, and environmental sustainability, and how this can have a positive impact on a country's long-term growth. All this is related to the case of the large-scale retail sector, examined as one of the few to have responded better, through processes of digital evolution, to the Covid-19 Pandemic

Social Innovation, Urban Regeneration, Circular City: A Cross- Country Analysis Post-Covid 19

The document studies urban regeneration as a sustainable development strategy for any city, emphasizing the sphere of urban reality (economic, social, and environmental). The aim is to examine the topic of urban regeneration to the concept of sustainable development after the impact of Covid-19. The paper analyzes how urban regeneration policies can contribute positively to the economic-social-environmental progress of the city. The research proposes a comparative analysis of three case studies of urban regeneration: Hammarby Sjöstad (Stockholm), Euromediterranée (Marseille), and the 'Ex Poligrafico (Rome)

Detection of Plasmodium falciparum male and female gametocytes and determination of parasite sex ratio in human endemic populations by novel, cheap and robust RTqPCR assays

The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection of submicroscopic infections with gametocytes and the estimation of the gametocyte sex ratio are crucial to assess the human host potential ability to infect mosquitoes and transmit malaria parasites

LA VALUTAZIONE DEGLI INVESTIMENTI PER LA MOBILITÀ: UN MODELLO MATEMATICO DI AIUTO ALLA DECISIONE

The Italian mobility system is characterized by obsolete, inefficient, often unsafe infrastructural networks and by long and complex processes in public administrations, as well as by procurement legal disputes that discourage private investments: these multiple factors hinder the socio-economic development and the national GDP growth. In the EU report “Transport in the European Union" of March 2019, Italy is below the European average, both in terms of the services quality and the reliability of the transport network, with over 80% car trips. Logistics, local public transport and related modal integrations (train-bus-bicycle, etc.), and tariffs are fundamental elements for “sustainable development". Considering the strategic importance and the problem relevance, in this paper, the variables characterizing the quadrinomial “infrastructural network-mobility service-economy-environment" are analysed in order to develop a mathematical model to support the decision-making process for transport investments. The proposed algorithm allows to evaluate the right choice among not indifferent alternatives which respect technical, economic and ecosystemic constraints. Thanks to this model, the project manager is able to evaluate and choose the best alternative for improving the “territory-mobility" system into a global configuration which considers the overall impact (all effects) of the investment, taking into account every possible scenario. The model is based on the elements of function theory and linear and relational algebra: through pre-established “input" parameters, a decision-making strategy is set up to achieve pre-established strategic objectives, with “excellent" decision trajectories which maximize the global utilities of the project or of the action program

Targeted sequencing of BRAF by MinION in archival Formalin-Fixed Paraffin-Embedded specimens allows to discriminate between Hairy Cell Leukemia and Hair Cell Leukemia Variant

Targeted sequencing of BRAF by MinION in archival Formalin-Fixed Paraffin-Embedded specimens allows to discriminate between Hairy Cell Leukemia and Hair Cell Leukemia Varian

Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels

L1 (also known as L1CAM) is a trans-membrane glycoprotein mediating neuron-neuron adhesion through homophilic and heterophilic interactions. Although experimental evidence has implicated L1 in axonal outgrowth, fasciculation and pathfinding, its contribution to voltage-gated Na+ channel function and membrane excitability has remained unknown. Here, we show that firing rate, single cell spiking frequency and Na+ current density are all reduced in hippocampal excitatory neurons from L1-deficient mice both in culture and in slices owing to an overall reduced membrane expression of Na+ channels. Remarkably, normal firing activity was restored when L1 was reintroduced into L1-deficient excitatory neurons, indicating that abnormal firing patterns are not related to developmental abnormalities, but are a direct consequence of L1 deletion. Moreover, L1 deficiency leads to impairment of action potential initiation, most likely due to the loss of the interaction of L1 with ankyrin G that produces the delocalization of Na+ channels at the axonal initial segment. We conclude that L1 contributes to functional expression and localization of Na+ channels to the neuronal plasma membrane, ensuring correct initiation of action potential and normal firing activity