Self-reported gait unsteadiness in mildly impaired neurological patients: an objective assessment through statistical gait analysis

Background Self-reported gait unsteadiness is often a problem in neurological patients without any clinical evidence of ataxia, because it leads to reduced activity and limitations in function. However, in the literature there are only a few papers that address this disorder. The aim of this study is to identify objectively subclinical abnormal gait strategies in these patients. Methods Eleven patients affected by self-reported unsteadiness during gait (4 TBI and 7 MS) and ten healthy subjects underwent gait analysis while walking back and forth on a 15-m long corridor. Time-distance parameters, ankle sagittal motion, and muscular activity during gait were acquired by a wearable gait analysis system (Step32, DemItalia, Italy) on a high number of successive strides in the same walk and statistically processed. Both self-selected gait speed and high speed were tested under relatively unconstrained conditions. Non-parametric statistical analysis (Mann-Whitney, Wilcoxon tests) was carried out on the means of the data of the two examined groups. Results The main findings, with data adjusted for velocity of progression, show that increased double support and reduced velocity of progression are the main parameters to discriminate patients with self-reported unsteadiness from healthy controls. Muscular intervals of activation showed a significant increase in the activity duration of the Rectus Femoris and Tibialis Anterior in patients with respect to the control group at high speed. Conclusions Patients with a subjective sensation of instability, not clinically documented, walk with altered strategies, especially at high gait speed. This is thought to depend on the mechanisms of postural control and coordination. The gait anomalies detected might explain the symptoms reported by the patients and allow for a more focused treatment design. The wearable gait analysis system used for long distance statistical walking assessment was able to detect subtle differences in functional performance monitoring, otherwise not detectable by common clinical examination

Folds and Buckles at the Nanoscale: Experimental and Theoretical Investigation of the Bending Properties of Graphene Membranes

The elastic properties of graphene crystals have been extensively investigated, revealing unique properties in the linear and nonlinear regimes, when the membranes are under either stretching or bending loading conditions. Nevertheless less knowledge has been developed so far on folded graphene membranes and ribbons. It has been recently suggested that fold-induced curvatures, without in-plane strain, can affect the local chemical reactivity, the mechanical properties, and the electron transfer in graphene membranes. This intriguing perspective envisages a materials-by-design approach through the engineering of folding and bending to develop enhanced nano-resonators or nano-electro-mechanical devices. Here we present a novel methodology to investigate the mechanical properties of folded and wrinkled graphene crystals, combining transmission electron microscopy mapping of 3D curvatures and theoretical modeling based on continuum elasticity theory and tight-binding atomistic simulations

Anti-de Sitter boundary in Poincare coordinates

We study the space-time boundary of a Poincare patch of Anti-de Sitter (AdS) space. We map the Poincare AdS boundary to the global coordinate chart and show why this boundary is not equivalent to the global AdS boundary. The Poincare AdS boundary is shown to contain points of the bulk of the entire AdS space. The Euclidean AdS space is also discussed. In this case one can define a semi-global chart that divides the AdS space in the same way as the corresponding Euclidean Poincare chart.Comment: In this revised version we add a discussion of the physical consequences of the choice of a coordinate system for AdS space. We changed figure 1 and added more references. Version to be published in Gen. Relat. Grav

Water relations of grapevine cv. Cortese with different training systems

Leaf (LWP) and stem water potential and stomatal conductance (SC) were measured during the day on grapevines trained with four different systems: traditional trellis, central curtain, Y trellis and double curtain. During most of the day LWP was lower and the stem to leaf water potential gradient was higher in the traditional trellis than in the other systems. On the contrary, very few differences were found as regards SC. Osmotic potential changed little during the day and among treatments. Traditional trellis vines had lower yield and total sugar production. The conclusion is drawn that training systems can affect water relations and in this way influence yield and must quality.Relations hydriques de vignes du cépage Cortese élevées sous différents systèmes de conduiteLe potentiel hydrique des feuilles (LWP) et des tiges et la conductance stomatique (SC) ont été mésurés le long du jour sur des plantes de vigne élevés sous quatre systèmes de conduite: vigne palissée en taille Guyot, rideau simple, système Y, rideau double. Pendant la plupart du jour LWP a été plus réduit dans les vignes en Guyot tandis que le gradient de potentiel entre feuille et tige a été plus éléve chez le même système de conduite. Au contraire, les différences au niveau de SC ont été négligeables. Le potentiel osmotique de la feuille a peu changé le long du jour et entre les systemès de conduite. Les vignes en Guyot ont produit moins de raisins et de sucre. Le mode de conduite peut affecter les relations hydriques de la vigne et donc modifier la production et la qualité du moût

Recent results of a seismically isolated optical table prototype designed for advanced LIGO

The Horizontal Access Module Seismic Attenuation System (HAM-SAS) is a mechanical device expressly designed to isolate a multipurpose optical table and fit in the tight space of the LIGO HAM Ultra-High-Vacuum chamber. Seismic attenuation in the detectors' sensitivity frequency band is achieved with state of the art passive mechanical attenuators. These devices should provide an attenuation factor of about 70dB above 10Hz at the suspension point of the Advanced LIGO triple pendulum suspension. Automatic control techniques are used to position the optical table and damp rigid body modes. Here, we report the main results obtained from the full scale prototype installed at the MIT LIGO Advanced System Test Interferometer (LASTI) facility. Seismic attenuation performance, control strategies, improvements and limitations are also discussed

Relativistic Green functions in a plane wave gravitational background

We consider a massive relativistic particle in the background of a gravitational plane wave. The corresponding Green functions for both spinless and spin 1/2 cases, previously computed by A. Barducci and R. Giachetti \cite{Barducci3}, are reobtained here by alternative methods, as for example, the Fock-Schwinger proper-time method and the algebraic method. In analogy to the electromagnetic case, we show that for a gravitational plane wave background a semiclassical approach is also sufficient to provide the exact result, though the lagrangian involved is far from being a quadratic one.Comment: Last paper by Professor Arvind Narayan Vaidya, 18 pages, no figure

Core-mantle boundary deformations and J2 variations resulting from the 2004 Sumatra earthquake

The deformation at the core-mantle boundary produced by the 2004 Sumatra earthquake is investigated by means of a semi-analytic theoretical model of global coseismic and postseismic deformation, predicting a millimetric coseismic perturbation over a large portion of the core-mantle boundary. Spectral features of such deformations are analysed and discussed. The time-dependent postseismic evolution of the elliptical part of the gravity field (J2) is also computed for different asthenosphere viscosity models. Our results show that, for asthenospheric viscosities smaller than 10^18 Pa s, the postseismic J2 variation in the next years is expected to leave a detectable signal in geodetic observations.Comment: 14 pages, 8 figures, 1 table. It will appear in Geophysical Journal Internationa

Vertebroplasty – High Viscosity Cement versus Low Viscosity Cement

The patients with intensive pain caused by the vertebra body fracture were treated by application of low viscosity cement (LVC),(Vertebroplastic, DePuy) and high viscosity cement (HVC),(Confidence, DePuy,) into the body, by means of diascopy through unilateral transpendicular approach. Application of LVC was made in 75 patients, on 109 vertebrae, and HVC was applied in 12 patients on 14 vertebrae. Application of LVC was performed on 48 thoracic and 61 lumbar vertebrae and 5 thoracic and 9 lumbar vertebrae were stabilized with HVC. 43 patients were treated for malignancy and in 38 for osteoporosis. For LVC, preoperative VAS score was 8.32 and 2.23 (p<0.00001) 24 hours after surgery, and it remained stable 3 month later. For HVC, preoperative VAS score was 7.99 and it was 2.5 (p<0.00001) 24 hours after surgery and 3 months later. In the group of patients treated with LVC, there was 1 serious complication, a paraparesis caused by the leakage of cement into the spinal canal, which was partially recovered after decompression and rehabilitation treatment and 2 superificial infections with S. epidermidis which were cured by means of antibiotics. In 32 vertebrae (32) cement leakage extra ossal, either into vein plexus or intradiscal during surgery were noticed. When HVC was applied, intradiscal leakage occurred in one case onl (8%). By means od Wilcoxon paired test a significant difference was found between the preoperative VAS, and the values immediately after surgery and 3 months later (Z=7.52, p<0.00001) when LVC was applied., and with HVC it was (Z=3.04, p<0.00001), which indicates that the fast achieved pain reduction remained stable during the 3 month follow-up. The vertebroplasty is a safe and efficient surgical method in treatment of compressive vertebrae fractures which do not react to the conventional method of treatment. This method, when HVC is applied, shows significantly less complications related to cement leakage