Cultural values predict national COVID-19 death rates

National responses to a pandemic require populations to comply through personal behaviors that occur in a cultural context. Here we show that aggregated cultural values of nations, derived from World Values Survey data, have been at least as important as top-down government actions in predicting the impact of COVID-19. At the population level, the cultural factor of cosmopolitanism, together with obesity, predict higher numbers of deaths in the first two months of COVID-19 on the scale of nations. At the state level, the complementary variables of government efficiency and public trust in institutions predict lower death numbers. The difference in effect between individual beliefs and behaviors, versus state-level actions, suggests that open cosmopolitan societies may face greater challenges in limiting a future pandemic or other event requiring a coordinated national response among the population. More generally, mass cultural values should be considered in crisis preparations

STEM Abstracting and Indexing (A&I) Tool Overlap Analysis in 2020: An Open Science Informed Approach Amid Pandemic Budgets

Objectives: Compare journal coverage of abstract and indexing tools commonly used within academic science and engineering research. Methods: Title lists of Compendex, Inspec, Reaxys, SciFinder, and Web of Science were provided by their respective publishers. These lists were imported into Excel and the overlap of the ISSN/EISSNs and journal titles was determined using the VLOOKUP command, which determines if the value in one cell can be found in a column of other cells. Results: There is substantial overlap between the Web of Science’s Science Citation Index Expanded and the Emerging Sources Citation Index, the largest database with 17,014 titles, and Compendex (63.6%), Inspec (71.0%), Reaxys (67.0%), and SciFinder (75.8%). SciFinder also overlaps heavily with Reaxys (75.9%). Web of Science and Compendex combined contain 77.6% of the titles within Inspec. Conclusion: Flat or decreasing library budgets combined with increasing journal prices result in an unsustainable system that will require a calculated allocation of resources at many institutions. The overlap of commonly indexed journals among abstracting and indexing tools could serve as one way to determine how these resources should be allocated

Research data sharing: Practices and attitudes of geophysicists

Open data policies have been introduced by governments, funders, and publishers over the past decade. Previous research showed a growing recognition by scientists of the benefits of data-sharing and reuse, but actual practices lag and are not always compliant with new regulations. The goal of this study is to investigate motives, attitudes, and data practices of the community of Earth and planetary geophysicists, a discipline believed to have accepting attitudes toward data sharing and reuse. A better understanding of the attitudes and current data-sharing practices of this scientific community could enable funders, publishers, data managers, and librarians to design systems and services that help scientists understand and adhere to mandates and to create practices, tools, and services that are scientist-focused. An online survey was distributed to the members of the American Geophysical Union, producing 1,372 responses from 116 countries. The attitudes of researchers to data sharing and reuse were generally positive, but in practice, scientists had concerns about sharing their own research data. These concerns include the possibility of potential data misuse and the need for assurance of proper citation and acknowledgement. Training and assistance in good data management practices are lacking in many scientific fields and might help to alleviate these doubts

Observed restrictive feeding practices among low- income mothers of pre- adolescents

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162798/2/ijpo12666_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162798/1/ijpo12666.pd

Key Modulatory Role of Presynaptic Adenosine A 2A

Basal ganglia processing results from a balanced activation of direct and indirect striatal efferent pathways, which are controlled by dopamine D1 and D2 receptors, respectively. Adenosine A2A receptors are considered novel antiparkinsonian targets, based on their selective postsynaptic localization in the indirect pathway, where they modulate D2 receptor function. The present study provides evidence for the existence of an additional, functionally significant, segregation of A2A receptors at the presynaptic level. Using integrated anatomical, electrophysiological, and biochemical approaches, we demonstrate that presynaptic A2A receptors are preferentially localized in cortical glutamatergic terminals that contact striatal neurons of the direct pathway, where they exert a selective modulation of corticostriatal neurotransmission. Presynaptic striatal A2A receptors could provide a new target for the treatment of neuropsychiatric disorders

Personal, Behavioral, and Socio-environmental Correlates of Emerging Adults’ Sustainable Food Consumption in a Cross-sectional Analysis

Abstract Objective: Describe how dietary intake patterns of US young adults align with the EAT-Lancet Planetary Health Diet (PHD) sustainable diet goals, and identify personal, behavioral, and socio-environmental correlates of sustainable intake. Design: Data on past-year dietary intake were captured using a food frequency questionnaire. The PHD was applied to specific food groups and a total PHD score was calculated. Linear regression models were used to identify associations between personal, behavioral, and socio-environmental factors and PHD scores. Setting: This cross-sectional analysis uses data from the second wave of EAT 2010-2018 (Eating and Activity over Time), a population-based longitudinal study recruited in Minnesota. Participants: Ethnically/racially diverse group of participants (n=1,308) with a mean age of 22.1 (SD 2.0) years. Results: The mean PHD score was 4.1 (SD 1.4) on a scale of 0-14, with 14 representing the most sustainable. On average, participants consumed fewer whole grains, fish, legumes, soy, and nuts than ideal for a sustainable diet, and an excess of eggs, added sugar, and meat. The PHD score was higher for participants with higher SES and greater educational attainment. Higher home availability of healthy food (β = 0.24, P < 0.001) and less frequent fast-food consumption (β = -0.26, P < 0.001) were the strongest correlates of PHD scores. Conclusions: Results suggest that a high percentage of participants may not be achieving the sustainable diet goals defined by the PHD. Reductions in meat consumption and increases in plant-based foods are necessary to increase the sustainability of US young adults’ diets

High probability neurotransmitter release sites represent an energy efficient design

At most synapses, the probability of neurotransmitter release from an active zone (PAZ) is low, a design thought to confer many advantages. Yet, high PAZ can also be found at synapses. Speculating that high PAZ confers high energy efficiency, we examined energy efficiency at terminals of two Drosophila motor neurons (MNs) synapsing on the same muscle fiber, but with contrasting average PAZ. Through electrophysiological and ultrastructural measurements we calculated average PAZ for MNSNb/d-Is and MN6-Ib terminals (0.33±0.10 and 0.11±0.02 respectively). Using a miles-per-gallon analogy, we calculated efficiency as the number of glutamate molecules released for each ATP molecule that powers the release and recycling of glutamate and the removal of calcium (Ca2+) and sodium (Na+). Ca2+ and Na+ entry were calculated by microfluorimetry and morphological measurements respectively. Terminals with the highest PAZ release more glutamate but admit less Ca2+ and Na+, supporting the hypothesis that high PAZ confers greater energy efficiency than low PAZ (0.13±0.02 and 0.06±0.01 respectively). In an analytical treatment of parameters that influence efficiency we found that efficiency could be optimized in either terminal by increasing PAZ. Terminals with highest PAZ operate closest to this optimum but are less active and less able to sustain high release rates. Adopting an evolutionary biological perspective, we interpret the persistence of low PAZ release sites at more active terminals to be the result of selection pressures for sustainable neurotransmitter release dominating selection pressures for high energy efficiency

A Glial Variant of the Vesicular Monoamine Transporter Is Required To Store Histamine in the Drosophila Visual System

Unlike other monoamine neurotransmitters, the mechanism by which the brain's histamine content is regulated remains unclear. In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and mediate the storage of histamine and other monoamines. We have studied the visual system of Drosophila melanogaster in which histamine is the primary neurotransmitter released from photoreceptor cells. We report here that a novel mRNA splice variant of Drosophila VMAT (DVMAT-B) is expressed not in neurons but rather in a small subset of glia in the lamina of the fly's optic lobe. Histamine contents are reduced by mutation of dVMAT, but can be partially restored by specifically expressing DVMAT-B in glia. Our results suggest a novel role for a monoamine transporter in glia that may be relevant to histamine homeostasis in other systems