Stability of fermionic Feshbach molecules in a Bose-Fermi mixture

In the wake of successful experiments in Fermi condensates, experimental attention is broadening to study resonant interactions in degenerate Bose-Fermi mixtures. Here we consider the properties and stability of the fermionic molecules that can be created in such a mixture near a Feshbach resonance (FR). To do this, we consider the two-body scattering matrix in the many-body environment, and assess its complex poles. The stability properties of these molecules strongly depend on their centre-of-mass motion, because they must satisfy Fermi statistics. At low centre-of-mass momenta the molecules are more stable than in the absence of the environment (due to Pauli-blocking effects), while at high centre-of-mass momenta nontrivial many body effects render them somewhat less stable

Dipolar Bose gases: Many-body versus mean-field description

We characterize zero-temperature dipolar Bose gases under external spherical confinement as a function of the dipole strength using the essentially exact many-body diffusion Monte Carlo (DMC) technique. We show that the DMC energies are reproduced accurately within a mean-field framework if the variation of the s-wave scattering length with the dipole strength is accounted for properly. Our calculations suggest stability diagrams and collapse mechanisms of dipolar Bose gases that differ significantly from those previously proposed in the literature

Wave Mechanics of a Two Wire Atomic Beamsplitter

We consider the problem of an atomic beam propagating quantum mechanically through an atom beam splitter. Casting the problem in an adiabatic representation (in the spirit of the Born-Oppenheimer approximation in molecular physics) sheds light on explicit effects due to non-adiabatic passage of the atoms through the splitter region. We are thus able to probe the fully three dimensional structure of the beam splitter, gathering quantitative information about mode-mixing, splitting ratios,and reflection and transmission probabilities

Evidence of Luttinger liquid behavior in one-dimensional dipolar quantum gases

The ground state and structure of a one-dimensional Bose gas with dipolar repulsions is investigated at zero temperature by a combined Reptation Quantum Monte Carlo (RQMC) and bosonization approach. A non trivial Luttinger-liquid behavior emerges in a wide range of intermediate densities, evolving into a Tonks-Girardeau gas at low density and into a classical quasi-ordered state at high density. The density dependence of the Luttinger exponent is extracted from the numerical data, providing analytical predictions for observable quantities, such as the structure factor and the momentum distribution. We discuss the accessibility of such predictions in current experiments with ultracold atomic and molecular gases.Comment: 4 pages, 3 EPS figures, Revtex

Dipolar Bose-Einstein condensates with dipole-dependent scattering length

We consider a Bose-Einstein condensate of polar molecules in a harmonic trap, where the effective dipole may be tuned by an external field. We demonstrate that taking into account the dependence of the scattering length on the dipole moment is essential to reproducing the correct energies and for predicting the stability of the condensate. We do this by comparing Gross-Pitaevskii calculations with diffusion Monte Carlo calculations. We find very good agreement between the results obtained by these two approaches once the dipole dependence of the scattering length is taken into account. We also examine the behavior of the condensate in non-isotropic traps

In Defence of Modest Doxasticism About Delusions

Here I reply to the main points raised by the commentators on the arguments put forward in my Delusions and Other Irrational Beliefs (OUP, 2009). My response is aimed at defending a modest doxastic account of clinical delusions, and is articulated in three sections. First, I consider the view that delusions are in-between perceptual and doxastic states, defended by Jacob Hohwy and Vivek Rajan, and the view that delusions are failed attempts at believing or not-quite-beliefs, proposed by Eric Schwitzgebel and Maura Tumulty. Then, I address the relationship between the doxastic account of delusions and the role, nature, and prospects of folk psychology, which is discussed by Dominic Murphy, Keith Frankish, and Maura Tumulty in their contributions. In the final remarks, I turn to the continuity thesis and suggest that, although there are important differences between clinical delusions and non-pathological beliefs, these differences cannot be characterised satisfactorily in epistemic terms. \u

Bogoliubov modes of a dipolar condensate in a cylindrical trap

The calculation of properties of Bose-Einstein condensates with dipolar interactions has proven a computationally intensive problem due to the long range nature of the interactions, limiting the scope of applications. In particular, the lowest lying Bogoliubov excitations in three dimensional harmonic trap with cylindrical symmetry were so far computed in an indirect way, by Fourier analysis of time dependent perturbations, or by approximate variational methods. We have developed a very fast and accurate numerical algorithm based on the Hankel transform for calculating properties of dipolar Bose-Einstein condensates in cylindrically symmetric traps. As an application, we are able to compute many excitation modes by directly solving the Bogoliubov-De Gennes equations. We explore the behavior of the excited modes in different trap geometries. We use these results to calculate the quantum depletion of the condensate by a combination of a computation of the exact modes and the use of a local density approximation

HHV-6A infection and systemic sclerosis: Clues of a possible association

Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, excessive extracellular matrix deposition, and fibrosis of the skin and internal organs. Several infectious agents, including human herpesvirus-6 (HHV-6), have been suggested as possible triggering factors, but a direct association is still missing. We characterized 26 SSc patients for the presence of HHV-6 in tissues and blood, the anti-HHV-6 response, HLA-G plasma levels, and KIR typing. Given the prominent role of endothelial cells (EC) in SSc pathogenesis, along with HHV-6 tropism for EC, we also investigated the expression of pro-fibrosis factors in HHV-6 infected EC. Results showed the presence of HHV-6A in skin biopsies, and an increased virus load was associated with disease severity and poor natural killer (NK) response against the virus, particularly in subjects exhibiting a KIR2 phenotype. HLA-G plasma levels were significantly higher in HHV- 6A/B-KIR2 positive SSc patients and in vitro HHV-6A infection-induced pro-fibrosis factors expression in EC, supporting its role in the development of the fibrosing process. Our data suggest an association between virus infection/reactivation and disease, opening the way to future studies to understand the mechanisms by which HHV-6A might contribute to the multifactorial pathogenesis of SSc

Propagator Resolved Transverse Relaxation Exchange Spectroscopy

We use the propagator resolved transverse relaxation exchange technique to look at the movement of fluid in three different types of rock samples. The two pore model previously used to fit molecular exchange simulations to the experimental data is expanded to accommodate the three site exchange seen in two of the samples. Estimated values for pore space characteristics from the simulations were compared to values calculated from X‐Ray CT data of the samples. While discrepancies exist between the NMR and X‐Ray CT results, the molecular exchange behavior estimated from the three samples reflects well with their morphology

Phosphorylated cofilin-2 is more prone to oxidative modifications on Cys39 and favors amyloid fibril formation

Cofilins are small protein of the actin depolymerizing family. Actin polymerization/depolymerization is central to a number of critical cellular physiological tasks making cofilin a key protein for several physiological functions of the cell. Cofilin activity is mainly regulated by phosphorylation on serine residue 3 making this post-translational modification key to the regulation of myofilament integrity. In fact, in this form, the protein segregates in myocardial aggregates in human idiopathic dilated cardiomyopathy. Since myofilament network is an early target of oxidative stress we investigated the molecular changes induced by oxidation on cofilin isoforms and their interplay with the protein phosphorylation state to get insight on whether/how those changes may predispose to early protein aggregation. Using different and complementary approaches we characterized the aggregation properties of cofilin-2 and its phosphomimetic variant (S3D) in response to oxidative stress in silico, in vitro and on isolated cardiomyocytes. We found that the phosphorylated (inactive) form of cofilin-2 is mechanistically linked to the formation of an extended network of fibrillar structures induced by oxidative stress via the formation of a disulfide bond between Cys39 and Cys80. Such phosphorylation-dependent effect is likely controlled by changes in the hydrogen bonding network involving Cys39. We found that the sulfide ion inhibits the formation of such structures. This might represent the mechanism for the protective effect of the therapeutic agent Na2S on ischemic injury