766 research outputs found
Construct Validity of Dimensions of Adaptive Behavior: A Multitrait-Multimethod Evaluation.
The construct validity of four dimensions of adaptive and maladaptive behavior was investigated using the multitrait-multimethod matrix procedure of Campbell and Fiske (1959). Measures off our traits cognitive competence, social competence, social maladaption, and personal maladaption were obtained on a sample of 157 persons with moderate, severe, or profound mental retardation using each of three methods of measurement-standardized assessment instrument, day shift staff ratings, and evening shift staff ratings. Applying the Campbell and Fiske rules of thumb and recently proposed structural equation modeling techniques to the data demonstrated strong convergent validity, clear discriminant validity, and only moderate levels of method variance in the observed measures. implications of the results for the assessment of adaptive behavior and its dimensional structure were discussed
4-(2-Benzoylethyl)benzoic acid
The title compound, C16H14O3, adopts a conformation in which each functional group is almost coplanar with its adjacent ring, while the two aromatic rings are twisted with respect to one another with a dihedral angle of 78.51 (3)°. The compound dimerizes by standard centrosymmetric hydrogen-bonded carboxyl pairing [O⋯O = 2.6218 (11) Å and O—H⋯O = 176 (2)°]. The packing includes two intermolecular C—H⋯O close contacts with the ketone group
(2RS,8aRS)-6-Oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene-2-carboxylic acid
The title racemate, C11H14O3, aggregates in the crystal structure as acid-to-ketone O—H⋯O hydrogen-bonding catemers whose components are glide-related. The relative stereochemistry at the carboxyl group arises spontaneously during the synthesis. Two intermolecular C—H⋯O=C close contacts were found, both involving the acid group
(2SR,4aSR,8aSR)-6-Oxoperhydronaphthalene-2-carboxylic acid
In the title racemic compound, C11H16O3, the molecule adopts a conformation that places its carboxyl group in an equatorial position. Molecules aggregate by hydrogen-bond pairing of carboxyl groups, yielding centrosymmetric dimers that are arranged into layers in the (020) planes
3-Oxocyclobutanecarboxylic acid: hydrogen bonding in a small-ring γ-keto acid
The title ketocarboxylic acid, C5H6O3, is the smallest carboxycyclanone to have its crystal structure determined. It adopts a chiral conformation, by rotation of its carboxyl O atoms away from the plane of skeletal symmetry that passes through the carboxyl carbon and both atoms of the ketone carbonyl. The four-membered ring is non-planar, with a shallow fold of 14.3 (1)° along a line connecting the two α-carbons of the ketone group. In the crystal, the molecules are linked by centrosymmetric hydrogen-bond pairing of ordered carboxylic acid groups [O⋯O = 2.6392 (12) Å and O—H⋯O = 175.74 (15)°], yielding two different sets of dimers, related by by a 21 screw axis in c, in the cell. A C—H⋯O interaction is also present
Eigenvalues of Laplacian with constant magnetic field on non-compact hyperbolic surfaces with finite area
We consider a magnetic Laplacian on a
noncompact hyperbolic surface \mM with finite area. is a real one-form
and the magnetic field is constant in each cusp. When the harmonic
component of satifies some quantified condition, the spectrum of
is discrete. In this case we prove that the counting function of
the eigenvalues of satisfies the classical Weyl formula, even
when $dA=0.
3-Acetylbenzoic acid
In the crystal structure of the title compound, C9H8O3, essentially planar molecules [the carboxyl group makes a dihedral angle of 4.53 (7)° with the plane of the ring, while the acid group forms a dihedral angle of 3.45 (8)° to the ring] aggregate by centrosymmetric hydrogen-bond pairing of ordered carboxyl groups. This yields dimers which have two orientations in a unit cell, creating a herringbone pattern. In addition, two close C—H⋯O intermolecular contacts exist: one is between a methyl H atom and the ketone of a symmetry-related molecule and the other involves a benzene H atom and the carboxyl group O atom of another molecule. The crystal studied was a non-merohedral twin with twin law [100, 00, 0] and a domain ratio of 0.8104(14): 0.1896(14)
Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature
Abstract The renal mesenchyme contains heterogeneous cells, including interstitial fibroblasts and pericytes, with key roles in wound healing. Although healing is impaired in aged kidneys, the effect of age and injury on the mesenchyme remains poorly understood. We characterized renal mesenchymal cell heterogeneity in young vs old animals and after ischemia‐reperfusion‐injury (IRI) using multiplex immunolabeling and single cell transcriptomics. Expression patterns of perivascular cell markers (α‐SMA, CD146, NG2, PDGFR‐α, and PDGFR‐β) correlated with their interstitial location. PDGFR‐α and PDGFR‐β co‐expression labeled renal myofibroblasts more efficiently than the current standard marker α‐SMA, and CD146 was a superior murine renal pericyte marker. Three renal mesenchymal subtypes; pericytes, fibroblasts, and myofibroblasts, were recapitulated with data from two independently performed single cell transcriptomic analyzes of murine kidneys, the first dataset an aging cohort and the second dataset injured kidneys following IRI. Mesenchymal cells segregated into subtypes with distinct patterns of expression with aging and following injury. Baseline uninjured old kidneys resembled post‐ischemic young kidneys, with this phenotype further exaggerated following IRI. These studies demonstrate that age modulates renal perivascular/interstitial cell marker expression and transcriptome at baseline and in response to injury and provide tools for the histological and transcriptomic analysis of renal mesenchymal cells, paving the way for more accurate classification of renal mesenchymal cell heterogeneity and identification of age‐specific pathways and targets
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