New Approach for Boat Motion Analysis in Rowing

In rowing, the study of the movement of the boat and of the rower in the boat is difficult. Indeed, the shell is quite narrow and fragile and it is impossible to use the classical apparatus for physiological and biomechanical analysis. For this reason, the physiological studies of rowers (cardiac and pulmonary parameters) have been more easily realised on specific and non specific ergometers (see Hagerman for an extensive review 1984): it is well known now, that rowers have exceptional aerobic possibilities and also use anaerobiosis for the start and the final part of the race (Hagerman 1984). In contrast, only a few publications deal with the movement of the boat and the rower. The velocity of the boat at different stroke rates (Martin and Bernfield 1980), the angular velocities of various articulations of the rowers (Nelson and Widule 1983) were studied by kinematic analysis. Though this technique is very useful, it does not catch the movements behind the subjects and is of no use to record physiological and mechanical parameters (Ishiko 1967). Some authors used DC recorder placed in a motor boat following the racing shell to record different parameters (Baird and Soroka 1952; Di Prampero 1971; Celentano 1974). But, this technique is not practical because of the need of a second operator to keep the cables out of the water. With the miniaturization, Ishiko proposed and used multichanneltelemetry to record the force of the rower and the acceleration of the boat (Ishiko 1967; Ishiko 1971). Schneider also used the same technique to record the force of the rower in the boat (Schneider 1978). Though this technique is excellent and powerful, it is also very expensive and quite sophisticated. Our goal was thus to take advantage of the miniaturization of the elements and to build and use a recorder and transducers that can be placed into the boat to record the acceleration of the boat and the propulsive force of the rower

Unusual and Unexpected Allergic Reactions Can Be Unraveled by Molecular Allergy Diagnostics

The fifth class of immunoglobulin, immunoglobulin E (IgE) was discovered in 1967 and has had immense importance for the understanding, diagnosis, and treatment of allergic disease. More than 50 years have passed and efforts to characterize, standardize, and refine allergens with the aim to improve clinical diagnosis and allergen-specific immunotherapy are still ongoing. Another important breakthrough was made in 1999 with the introduction of component-resolved diagnostics (CRD), making it possible to quantify IgE antibodies against individual allergen proteins for diagnostic purposes at a molecular level. The progress and developments made in allergy diagnosis often originate from clinical observations and case studies. Observant physicians and health-care personnel have reported their findings in the medical literature, which in turn has inspired researchers to become involved in clinical research. Allergists continuously encounter new allergies and are often asked by their patients how to prevent new reactions. In the current article, we focus on recent clinical observations that can now be explained by CRD. The examples taken concern allergic reactions toward peanuts, tree nuts, lemon kernels, health drinks, meat, insects, dog dander, cannabis, and semen. We now have an improved understanding of why patients may react in a serious or unexpected way, as illustrated by these examples, yet many other clinical observations remain unexplained. The aim of this review is to highlight the importance of clinical observations among allergic patients, focusing on systemic, or unusual and unexpected allergic reactions, where component-testing has further refined the diagnosis of IgE-mediated allergy

A Review on the Application of Voltammetry in the Determination of Various Substances in Fruit Juices

Voltammetry is preferred amongst other detection techniques for vitamins and antioxidants because of its selectivity, sensitivity, ease of access, and inexpensive instrumentation. This study aims to assess and evaluate existing studies revolving around the voltammetric determination of vitamins and antioxidants of fruit juices, seeing as they are a rich source of vitamins and antioxidants, to find commonalities and trends over the years. Literature studies found differential pulse voltammetry (DPV) and square wave voltammetry (SWV) to be the most utilized determination method for vitamins and antioxidants, respectively. Electrode performance was also compared between bare and modified electrodes by comparing the limit of detection and recovery rate of each sample. Bare electrodes are found to be suitable for the detection of vitamins by having a high level of detection (LOD) values, but modified electrodes seemed to display enhanced performance when compared to the bare electrode. The optimal pH value of the supporting electrolyte in vitamins is 5.0 ≤ pH ≤ 7.0, while it was found that the optimal pH value for antioxidants was 2.0 ≤ pH ≤ 6.0. Voltammetric determination is highly dependent on the combination of the method, the material used in making the electrode, and the pH of the supporting electrolyte solution

Early Life Wheeze and Risk Factors for Asthma-A Revisit at Age 7 in the GEWAC-Cohort

One third of all toddlers are in need of medical care because of acute wheeze and many of these children have persistent asthma at school age. Our aims were to assess risk factors for and the prevalence of asthma at age 7 in a cohort of children suffering from an acute wheezing episode as toddlers. A total of 113 children, included during an acute wheezing episode (cases), and 54 healthy controls were followed prospectively from early pre-school age to 7 years. The protocol included questionnaires, ACT, FeNO, nasopharyngeal virus samples, blood sampling for cell count, vitamin D levels, and IgE to food and airborne allergens. The prevalence of asthma at age 7 was 70.8% among cases and 1.9% among controls (p &lt; 0.001). Acute wheeze caused by rhinovirus (RV) infection at inclusion was more common among cases with asthma at age 7 compared to cases without asthma (p = 0.011) and this association remained significant following adjustment for infection with other viruses (OR 3.8, 95% CI 1.4-10.5). Cases with asthma at age 7 had been admitted to hospital more often (p = 0.024) and spent more days admitted (p = 0.01) during the year following inclusion compared to cases without asthma. RV infection stands out as the main associated factor for wheeze evolving to persistent asthma. Cases who developed asthma also had an increased need of hospital time and care for wheeze during the year after inclusion.De två sista författarna delar sistaförfattarskapet.</p

Randomized controlled trial of slow peanut oral immunotherapy in young children : SmaChO study protocol

Peer reviewe

Inflammatory related plasma proteins involved in acute preschool wheeze

Background Preschool wheeze is a risk factor for asthma development. However, the molecular mechanism behind a wheezing episode is not well understood. Objective Our aims were to assess the association of plasma proteins with acute preschool wheeze and to study the proteins with differential expression at the acute phase at revisit after 3 months. Additionally, to investigate the relationship between protein expression and clinical parameters. Method We measured 92 inflammatory proteins in plasma and clinical parameters from 145 children during an episode of preschool wheeze (PW) and at the revisit after 3 months (PW-R, n = 113/145) and 101 healthy controls (HC) aged 6–48 months in the GEWAC cohort using the antibody-mediated proximity extension-based assay (Olink Proteomics, Uppsala). Results Of the 74 analysed proteins, 52 were differentially expressed between PW and HC. The expression profiles of the top 10 proteins, Oncostatin M (OSM), IL-10, IL-6, Fibroblast growth factor 21 (FGF21), AXIN1, CXCL10, SIRT2, TNFSF11, Tumour necrosis factor β (TNF-β) and CASP8, could almost entirely separate PW from HC. Five out of 10 proteins were associated with intake of oral corticosteroids (OCS) 24 h preceding blood sampling (OSM, CASP8, IL-10, TNF-β and CXCL10). No differences in protein expression were seen between PWs with or without OCS in comparison to HC. At the revisit after 3 months, differential protein expressions were still seen between PW-R and HC for three (IL-10, SIRT2 and FGF21) of the 10 proteins. Conclusion Our results contribute to unravelling potential immunopathological pathways shared between preschool wheeze and asthma