Susy QCD and High Energy Cosmic Rays 1. Fragmentation functions of Susy QCD

The supersymmetric evolution of the fragmentation functions (or timelike evolution) within N=1 $QCD$ is discussed and predictions for the fragmentation functions of the theory (into final protons) are given. We use a backward running of the supersymmetric DGLAP equations, using a method developed in previous works. We start from the usual QCD parameterizations at low energy and run the DGLAP back, up to an intermediate scale -assumed to be supersymmetric- where we switch-on supersymmetry. From there on we assume the applicability of an N=1 supersymmetric evolution (ESAP). We elaborate on possible application of these results to High Energy Cosmic Rays near the GZK cutoff.Comment: 36 pages, 12 fig

Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives

The crucial role of the myofibroblast in wound healing and fibrosis development is well established. This review discusses the mechanisms of myofibroblast action and the new findings that may develop into therapeutic strategies during the next few years

The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

Myofibroblasts are specialized fibroblasts responsible for granulation tissue contraction and the soft tissue retractions occurring during fibrocontractive diseases. The marker of fibroblast-myofibroblast modulation is the neo expression of α–smooth muscle actin (α-SMA), the actin isoform typical of vascular smooth muscle cells that has been suggested to play an important role in myofibroblast force generation. Actin isoforms differ slightly in their NH2-terminal sequences; these conserved differences suggest different functions. When the NH2-terminal sequence of α-SMA Ac-EEED is delivered to cultured myofibroblast in the form of a fusion peptide (FP) with a cell penetrating sequence, it inhibits their contractile activity; moreover, upon topical administration in vivo it inhibits the contraction of rat wound granulation tissue. The NH2-terminal peptide of α–skeletal actin has no effect on myofibroblasts, whereas the NH2-terminal peptide of β–cytoplasmic actin abolishes the immunofluorescence staining for this isoform without influencing α-SMA distribution and cell contraction. The FPs represent a new tool to better understand the specific functions of actin isoforms. Our findings support the crucial role of α-SMA in wound contraction. The α-SMA–FP will be useful for the understanding of the mechanisms of connective tissue remodeling; moreover, it furnishes the basis for a cytoskeleton-dependent preventive and/or therapeutic strategy for fibrocontractive pathological situations

The 22nd annual meeting of the European Tissue Repair Society (ETRS) in Athens, Greece

The 22nd Annual Meeting of the European Tissue Repair Society, Athens, Greece, October 4 to 5, 2012 informed about pathophysiological mechanisms in tissue repair and on the development of clinical treatments of chronic wounds, fibrosis, and cancer, considering recent advances in molecular biology and biotechnology

Automatic Feature-Based Point Cloud Registration for a Moving Sensor Platform

The automatic and accurate alignment of multiple point clouds is a basic requirement for an adequate digitization, reconstruction and interpretation of large 3D environments. Due to the recent technological advancements, modern devices are available which allow for simultaneously capturing intensity and range images with high update rates. Hence, such devices can even be used for dynamic scene analysis and for rapid mapping which is particularly required for environmental applications and disaster management, but unfortu-nately, they also reveal severe restrictions. Facing challenges with respect to noisy range measurements, a limited non-ambiguous range, a limited field of view and the occurrence of scene dynamics, the adequate alignment of captured point clouds has to satisfy additional constraints compared to the classical registration of terrestrial laser scanning (TLS) point clouds for describing static scenes. In this paper, we propose a new methodology for point cloud registration which considers such constraints while maintaining the fundamental properties of high accuracy and low computational effort without relying on a good initial alignment or human interaction. Exploiting 2D image features and 2D/2D correspondences, sparse point clouds of physically almost identical 3D points are derived. Subsequently, these point clouds are aligned with a fast procedure directly taking into account the reliability of the detected correspondences with respect to geometric and radiometric information. The proposed methodology is evaluated and its performance is demonstrated for data captured with a moving sensor platform which has been designed for monitoring from low altitudes. Due to the provided reliability and a fast processing scheme, the proposed methodology offers a high potential for dynamic scene capture and analysis.

PREFACE: TECHNICAL COMMISSION I

For ISPRS Technical Commission I (TC I), 76 submissions for the 2021 Congress edition of ISPRS Annals and ISPRS Archives were received. This included both full paper and abstract submissions from all over the world. Continuing the success of double blind paper reviewing in preparation of the 2016 Prague congress, the 2018 Karlsruhe symposium as well as the 2020 edition of the ISPRS congress, also this time, TC I organized a strict peer-reviewing process. This included double-blind reviewing for full papers as well as a two-stage evaluation of abstract submissions – first stage based on the submitted abstracts (“conditional acceptance”), and second stage after submission of the respective final papers.For the 2021 edition of the ISPRS congress, we received 32 full paper submissions and 46 abstract submissions, which underlines the trend towards full paper submissions compared to previous TC I events.17 full papers passed the double-blind peer-review process and were accepted for publication in the ISPRS Annals (acceptance rate 53%); none of the papers was reviewed by less than two reviewers; for the majority of full papers, three or four reviews were obtained. Abstract submissions and their respective final papers were reviewed by a team of professionals. In total, 28 papers were accepted to the ISPRS Archives.Strict peer-reviewing relies on many voluntary reviewers spending their time for reading and evaluating the submissions. We would like to express our thanks to our reviewing team – especially since they were again willing to contribute to the review process just after completion of the 2020 edition of the ISPRS congress.The manuscripts in both the ISPRS Annals and Archives cover a broad range of topics related to remote sensing platforms, technologies, systems and related methods and reflect the current trends in algorithmic research and developments in sensing and data acquisition methods. Noteworthy is that numerous contributions were again submitted to Intercommission WGs of TC I with TC II and TC IV, which underlines the continuing trend towards an integral approach to sensors, systems and methods in photogrammetry, remote sensing and mobile mapping.</p

Marching at the front and dragging behind: differential αVβ3-integrin turnover regulates focal adhesion behavior

Integrins are cell–substrate adhesion molecules that provide the essential link between the actin cytoskeleton and the extracellular matrix during cell migration. We have analyzed αVβ3-integrin dynamics in migrating cells using a green fluorescent protein–tagged β3-integrin chain. At the cell front, adhesion sites containing αVβ3-integrin remain stationary, whereas at the rear of the cell they slide inward. The integrin fluorescence intensity within these different focal adhesions, and hence the relative integrin density, is directly related to their mobility. Integrin density is as much as threefold higher in sliding compared with stationary focal adhesions. High intracellular tension under the control of RhoA induced the formation of high-density contacts. Low-density adhesion sites were induced by Rac1 and low intracellular tension. Photobleaching experiments demonstrated a slow turnover of β3-integrins in low-density contacts, which may account for their stationary nature. In contrast, the fast β3-integrin turnover observed in high-density contacts suggests that their apparent sliding may be caused by a polarized renewal of focal contacts. Therefore, differential acto-myosin–dependent integrin turnover and focal adhesion densities may explain the mechanical and behavioral differences between cell adhesion sites formed at the front, and those that move in the retracting rear of migrating cells