IMUNOHISTOKEMIJSKA IZRAŽENOST PROTEINA BORIS U TUMORIMA ZAMETNIH STANICA TESTISA

Brother of the Regulator of Imprinted Sites (BORIS) has a role in intracellular signalization and is important in epigenetic mechanism control, such as methylation/demethylation of DNA and histones. BORIS may deregulate some tumor suppressor genes. Immunohistochemical expression of BORIS was found in different tumors, some of them showing correlation with poor prognosis. The aim of this study was to determine immunohistochemical expression of BORIS in pure seminomas and different components of testicular mixed germ cell tumors (MGCT). In this study, immunohistochemical expression of BORIS in testicular germ cell tumors (TGCT) was analyzed. Staining intensity and percentage of positive staining cells were used to evaluate the level of expression. Tumor samples from 44 patients were analyzed; 26 pure seminomas and 18 MGCT. In MGCTs, seminoma component was found in 4, yolk sac in 7, teratoma in 11 and embryonal carcinoma in 13 samples. Expression of BORIS was strong in 80.8% of seminoma cases and in 76.9% of embryonal carcinoma component, 71.4% of yolk sac, 63.6% of teratoma component and 25% of seminomatous component of MGCT. In MGCT, positive correlation was found between BORIS expression in teratomatous component and presence of yolk sac component (BORIS (engl. Brother of the Regulator of Imprinted Sites) sudjeluje u unutarstaničnoj signalizaciji i kontrolira epigenetske mehanizme kao što su metilacija/demetilacija DNK i histona. Aktivacija BORIS-a dovodi do poremećaja određenih tumorskih supresora. Imunohistokemijska izraženost BORIS-a utvrđena je u različitim tumorima. U nekim tumorima nađena je korelacija s lošijom prognozom. Cilj ovoga istraživanja bio je utvrditi imunohistokemijsku izraženost BORIS-a u čistim seminomima i različitim komponentama miješanih tumora zametnih stanica testisa (engl. mixed germ cell tumors, MGCT). Materijal i metode: Analizirana je imunohistokemijska izraženost BORIS-a u tumorima zametnih stanica testisa (engl. testicular germ cell tumors, TGCT), a intenzitet bojenja i postotak reaktivnih stanica korišten je za evaluaciju razine ekspresije. Analizirani su uzorci tumora 44 bolesnika; 26 čistih seminoma i 18 MGCT. Kod MGCT-a komponenta seminoma nađena je u 4, yolk sac-a u 7, teratoma u 11 te embrionalnog karcinoma u 13 uzoraka tumora. Rezultati: Imunohistokemijska izraženost bila je jaka kod 80,8% čistih seminoma te kod 76,9% komponente embrionalnog karcinoma, 71,4% yolk sac-a, 63,6% teratoma i 25% seminomske komponente MGCT-a. Dobivena je pozitivna korelacija izraženosti BORIS-a teratomske komponente i prisutnosti komponente yolc sac

IMUNOHISTOKEMIJSKA IZRAŽENOST PROTEINA BORIS U TUMORIMA ZAMETNIH STANICA TESTISA

Brother of the Regulator of Imprinted Sites (BORIS) has a role in intracellular signalization and is important in epigenetic mechanism control, such as methylation/demethylation of DNA and histones. BORIS may deregulate some tumor suppressor genes. Immunohistochemical expression of BORIS was found in different tumors, some of them showing correlation with poor prognosis. The aim of this study was to determine immunohistochemical expression of BORIS in pure seminomas and different components of testicular mixed germ cell tumors (MGCT). In this study, immunohistochemical expression of BORIS in testicular germ cell tumors (TGCT) was analyzed. Staining intensity and percentage of positive staining cells were used to evaluate the level of expression. Tumor samples from 44 patients were analyzed; 26 pure seminomas and 18 MGCT. In MGCTs, seminoma component was found in 4, yolk sac in 7, teratoma in 11 and embryonal carcinoma in 13 samples. Expression of BORIS was strong in 80.8% of seminoma cases and in 76.9% of embryonal carcinoma component, 71.4% of yolk sac, 63.6% of teratoma component and 25% of seminomatous component of MGCT. In MGCT, positive correlation was found between BORIS expression in teratomatous component and presence of yolk sac component (BORIS (engl. Brother of the Regulator of Imprinted Sites) sudjeluje u unutarstaničnoj signalizaciji i kontrolira epigenetske mehanizme kao što su metilacija/demetilacija DNK i histona. Aktivacija BORIS-a dovodi do poremećaja određenih tumorskih supresora. Imunohistokemijska izraženost BORIS-a utvrđena je u različitim tumorima. U nekim tumorima nađena je korelacija s lošijom prognozom. Cilj ovoga istraživanja bio je utvrditi imunohistokemijsku izraženost BORIS-a u čistim seminomima i različitim komponentama miješanih tumora zametnih stanica testisa (engl. mixed germ cell tumors, MGCT). Materijal i metode: Analizirana je imunohistokemijska izraženost BORIS-a u tumorima zametnih stanica testisa (engl. testicular germ cell tumors, TGCT), a intenzitet bojenja i postotak reaktivnih stanica korišten je za evaluaciju razine ekspresije. Analizirani su uzorci tumora 44 bolesnika; 26 čistih seminoma i 18 MGCT. Kod MGCT-a komponenta seminoma nađena je u 4, yolk sac-a u 7, teratoma u 11 te embrionalnog karcinoma u 13 uzoraka tumora. Rezultati: Imunohistokemijska izraženost bila je jaka kod 80,8% čistih seminoma te kod 76,9% komponente embrionalnog karcinoma, 71,4% yolk sac-a, 63,6% teratoma i 25% seminomske komponente MGCT-a. Dobivena je pozitivna korelacija izraženosti BORIS-a teratomske komponente i prisutnosti komponente yolc sac

Nucleon-Nucleon Scattering and Large N(c) QCD

Nucleon-nucleon scattering observables are discussed in the context of large Nc QCD. As is well known, the baryon spectrum in the large Nc limit exhibits contracted SU(2Nf) spin-flavor sym- metry. This symmetry can be used to derive model-independent relations between proton-proton and proton-neutron total cross sections. These relations are valid in the kinematic regime in which the relative momentum of two nucleons is of order of Nc. In this semiclassical regime the nucleon-nucleon scattering can be described in the time-dependent mean field approximation. These model-independent results are compared to experimental data for spin-independent and polarized total nucleon-nucleon cross sections.Comment: 9 pages, 3 figures. Invited talk, Xth Quark Confinement and the Hadron Spectrum, October 201

VOA[MM_4]

We take a peek at a general program that associates vertex (or, chiral) algebras to smooth 4-manifolds in such a way that operations on algebras mirror gluing operations on 4-manifolds and, furthermore, equivalent constructions of 4-manifolds give rise to equivalences (dualities) of the corresponding algebras

Correlations and Pairing Between Zeros and Critical Points of Gaussian Random Polynomials

We study the asymptotics of correlations and nearest neighbor spacings between zeros and holomorphic critical points of $p_N$, a degree N Hermitian Gaussian random polynomial in the sense of Shiffman and Zeldtich, as N goes to infinity. By holomorphic critical point we mean a solution to the equation $\frac{d}{dz}p_N(z)=0.$ Our principal result is an explicit asymptotic formula for the local scaling limit of \E{Z_{p_N}\wedge C_{p_N}}, the expected joint intensity of zeros and critical points, around any point on the Riemann sphere. Here $Z_{p_N}$ and $C_{p_N}$ are the currents of integration (i.e. counting measures) over the zeros and critical points of $p_N$, respectively. We prove that correlations between zeros and critical points are short range, decaying like e^{-N\abs{z-w}^2}. With \abs{z-w} on the order of $N^{-1/2},$ however, \E{Z_{p_N}\wedge C_{p_N}}(z,w) is sharply peaked near $z=w,$ causing zeros and critical points to appear in rigid pairs. We compute tight bounds on the expected distance and angular dependence between a critical point and its paired zero.Comment: 35 pages, 3 figures. Some typos corrected and Introduction revise