Hydrogeological characterization of peculiar Apenninic springs

Abstract. In the northern Apennines of Italy, springs are quite widespread over the slopes. Due to the outcropping of low-permeability geologic units, they are generally characterized by low-yield capacities and high discharge variability during the hydrologic year. In addition, low-flow periods (discharge lower than 1 Ls-1) reflect rainfall and snowmelt distribution and generally occur in summer seasons. These features strongly condition the management for water-supply purposes, making it particularly complex. The "Mulino delle Vene" springs (420 m a.s.l., Reggio Emilia Province, Italy) are one of the largest in the Apennines for mean annual discharge and dynamic storage and are considered as the main water resource in the area. They flow out from several joints and fractures at the bottom of an arenite rock mass outcrop in the vicinity of the Tresinaro River. To date, these springs have not yet been exploited, as the knowledge about the hydrogeological characteristics of the aquifer and their hydrological behaviour is not fully achieved. This study aims to describe the recharge processes and to define the hydrogeological boundaries of the aquifer. It is based on river and spring discharge monitoring and groundwater balance assessment carried out during the period 2012–2013. Results confirm the effectiveness of the approach, as it allowed the total aliquot of discharge of the springs to be assessed. Moreover, by comparing the observed discharge volume with the one calculated with the groundwater balance, the aquifer has been identified with the arenite slab (mean altitude of 580 m a.s.l.), extended about 5.5 km2 and located 1 km west of the monitored springs

Nuclear Diacylglycerol Produced by Phosphoinositide-specific Phospholipase C Is Responsible for Nuclear Translocation of Protein Kinase C-α

It is well established that an independent inositide cycle is present within the nucleus, where it is involved in the control of cell proliferation and differentiation. Previous results have shown that when Swiss 3T3 cells are treated with insulin-like growth factor-I (IGF-I) a rapid and sustained increase in mass of diacylglycerol (DAG) occurs within the nuclei, accompanied by a decrease in the levels of both phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. However, it is unclear whether or not other lipids could contribute to this prolonged rise in DAG levels. We now report that the IGF-I-dependent increase in nuclear DAG production can be inhibited by the specific phosphatidylinositol phospholipase C inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine or by neomycin sulfate but not by the purported phosphatidylcholine-phospholipase C specific inhibitor D609 or by inhibitors of phospholipase D-mediated DAG generation. Treatment of cells with 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine or neomycin sulfate inhibited translocation of protein kinase C-alpha to the nucleus. Moreover, exposure of cells to 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine, but not to D609, dramatically reduced the number of cells entering S-phase upon stimulation with IGF-I. These results suggest that the only phospholipase responsible for generation of nuclear DAG after IGF-I stimulation of 3T3 cells is PI-PLC. When this activity is inhibited, neither DAG rise is seen nor PKC-alpha translocation to the nucleus occurs. Furthermore, this PI-PLC activity appears to be essential for the G0/G1 to S-phase transition

Beautiful and Grotesque: Signifiers of Morality and Power in Okpella Masking Traditions (Nigeria): Bella y grotesca. Significantes de moralidad y poder en las tradiciones de la máscara okpella (Nigeria)

Paired masks described as beautiful and grotesque express complementary values in several southern Nigerian art traditions. Beautiful masks represent humans, often women, and serve as metaphors for things associated with civilization and culture. Grotesque masks represent animals or men, and tend to be linked with notions of masculinity and nature. Analysis of masks falling into these categories provides us with a set of formal criteria for this imagery. Mask types that fall into this continuum are used by the Okpella, a northern Edo people living north of Benin City in southern Nigeria: a female character commemorating specific women of status and described as beautiful (osomhotse), a more ambiguous character that serves as the festival herald and messenger of the Dead Fathers described as grotesque (ulishi), and a third masquerade that combines elements of both the beautiful and grotesque is described as fascinating (efofe). Why and how these forms communicate to their Okpella audience is the focus of this paper. It is based on qualitative research on the history and meaning of these masks carried out among the Okpella (1972-1974), survey research on aesthetic preference (1979) in which 400 individuals were interviewed, and with a panel study (2003) in which 100 participants from the original sample were re-interviewed. Key words: beautiful, grotesque, Africa, okpella, masquerade, aesthetics.   Resumen Las máscaras emparejadas descritas como ‘bellas’ y ‘grotescas’ expresan valores complementarios en varias tradiciones artísticas del sur de Nigeria. Las máscaras bellas representan a los humanos, frecuentemente mujeres, y se emplean como metáforas de aspectos asociados con la civilización y la cultura. Las máscaras grotescas representan animales u hombres, y suelen vincularse con nociones de masculinidad y de naturaleza. El análisis de las máscaras que entran en estas dos categorías proporciona un conjunto de criterios formales para comprender este imaginario. El grupo étnico Edo del norte que vive al norte de Ciudad de Benín en el sur de Nigeria, los okpella, usan máscaras de este tipo. Existe un personaje femenino descrito como bello (osomhotse), un personaje más ambiguo descrito como grotesco (ulishi) y un tercero que combina elementos del bello y del grotesco y que se describe como fascinante (efofe). En este artículo nos interesamos en qué y cómo comunican estas formas con los okpella. Nuestro trabajo se apoya sobre una investigación cualitativa realizada entre los okpella (1972-1974), una encuesta sobre preferencia estética (1979) en la cual se entrevistó a 400 personas y un estudio (2003) en el cual se volvió a entrevistar a 100 personas de la muestra anterior. Palabras clave: belleza, grotesco, África, okpella, mascarada, estética.

Characterizing Distances of Networks on the Tensor Manifold

At the core of understanding dynamical systems is the ability to maintain and control the systems behavior that includes notions of robustness, heterogeneity, or regime-shift detection. Recently, to explore such functional properties, a convenient representation has been to model such dynamical systems as a weighted graph consisting of a finite, but very large number of interacting agents. This said, there exists very limited relevant statistical theory that is able cope with real-life data, i.e., how does perform analysis and/or statistics over a family of networks as opposed to a specific network or network-to-network variation. Here, we are interested in the analysis of network families whereby each network represents a point on an underlying statistical manifold. To do so, we explore the Riemannian structure of the tensor manifold developed by Pennec previously applied to Diffusion Tensor Imaging (DTI) towards the problem of network analysis. In particular, while this note focuses on Pennec definition of geodesics amongst a family of networks, we show how it lays the foundation for future work for developing measures of network robustness for regime-shift detection. We conclude with experiments highlighting the proposed distance on synthetic networks and an application towards biological (stem-cell) systems.Comment: This paper is accepted at 8th International Conference on Complex Networks 201

Kinematic Analysis of the 2020 Elliot Creek Landslide, British Columbia, Using Remote Sensing Data

The 2020 Elliot Creek landslide-tsunami-flood cascade originated from an 18.3 Mm3 rock slope failure in quartz diorite bedrock in a valley undergoing rapid glacial retreat. We used airborne LiDAR and optical imagery to characterize the slope and its surroundings. Using the LiDAR, we determined that two rockslides (2020 and an older undated one) occurred on this slope and shared a common basal rupture surface. We mapped two main sets of lineaments that represent structures that controlled the orientation of the lateral and rear release surfaces. Analysis of the topographic profile indicates a wedge-shaped failure block and a stepped rupture surface. Further topographic profile analysis indicates the possibility of a structurally controlled geomorphic step in the valley that corresponds with a change in the orientation of the valley. The rapid retreat of the West Grenville Glacier and the positions of the rupture surfaces suggest glacial retreat played a role in the landslides

Finding the Needle in a Haystack: Who are the Most Central Authors Within a Domain?

The speed at which new scientific papers are published has increased dramatically, while the process of tracking the most recent publications having a high impact has become more and more cumbersome. In order to support learners and researchers in retrieving relevant articles and identifying the most central researchers within a domain, we propose a novel 2-mode multilayered graph derived from Cohesion Network Analysis (CNA). The resulting extended CNA graph integrates both authors and papers, as well as three principal link types: coauthorship, co-citation, and semantic similarity among the contents of the papers. Our rankings do not rely on the number of published documents, but on their global impact based on links between authors, citations, and semantic relatedness to similar articles. As a preliminary validation, we have built a network based on the 2013 LAK dataset in order to reveal the most central authors within the emerging Learning Analytics domain.This study is part of the RAGE project. The RAGE project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 644187. This publication reflects only the author's view. The European Commission is not responsible for any use that may be made of the information it contains

Feasibility and effectiveness assessment of sars-cov-2 antigenic tests in mass screening of a pediatric population and correlation with the kinetics of viral loads

The gold standard for diagnosis of SARS-CoV-2 infection has been nucleic acid amplification tests (NAAT). However, rapid antigen detection kits (Ag-RDTs), may offer advantages over NAAT in mass screening, generating results in minutes, both as laboratory-based test or point-of-care (POC) use for clinicians, at a lower cost. We assessed two different POC Ag-RDTs in mass screening versus NAAT for SARS-CoV-2 in a cohort of pediatric patients admitted to the Pediatric Emergency Unit of IRCCS—Polyclinic of Sant’Orsola, Bologna (from November 2020 to April 2021). All patients were screened with nasopharyngeal swabs for the detection of SARS-CoV-2-RNA and for antigen tests. Results were obtained from 1146 patients. The COVID-19 Ag FIA kit showed a baseline sensitivity of 53.8% (CI 35.4–71.4%), baseline specificity 99.7% (CI 98.4–100%) and overall accuracy of 80% (95% CI 0.68–0.91); the AFIAS COVID-19 Ag kit, baseline sensitivity of 86.4% (CI 75.0–93.9%), baseline specificity 98.3% (CI 97.1–99.1%) and overall accuracy of 95.3% (95% CI 0.92– 0.99). In both tests, some samples showed very low viral load and negative Ag-RDT. This disagreement may reflect the positive inability of Ag-RDTs of detecting antigen in late phase of infection. Among all cases with positive molecular test and negative antigen test, none showed viral loads > 106 copies/mL. Finally, we found one false Ag-RDTs negative result (low cycle thresholds; 9 × 105 copies/mL). Our results suggest that both Ag-RDTs showed good performances in detection of high viral load samples, making it a feasible and effective tool for mass screening in actively infected children