Introduction to the urban ecologies open collection: A call for contributions on methods, ethics, and design in geographical research with urban animals

This Open Collection proposes innovative research directions for both urban and beyond/more-than-/non-human geographies with animals. We are seeking papers for this Open Collection across three themes: (1) methods; (2) ethics and politics; and (3) planning and design. Specifically, we are interested in papers that pose questions of and reflect upon emergent tensions in researching with urban animals in each of these themes. This Open Collection aims to explore urban space beyond the human lens and to offer new modalities and frameworks for geographical research with urban animals. We are interested in papers that explore urban geographies with animals from a range of different theoretical, methodological, and empirical locations and perspectives. In this introduction to the Open Collection, we briefly summarise existing research in this field, before outlining the three thematic areas of the CollectionThis paper was funded by Dr. Maan Barua's European Research Council Horizon 2020 grant, “Urban ecologies: governing nonhuman life in global cities,” grant number 759239

Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo

Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal ion and PA residue D683 are critical for ANTXR1-PA binding. Since PA can bind to ANTXR2 with reduced affinity in the absence of metal ions, we reasoned that D683 mutant forms of PA might specifically interact with ANTXR2. We show here that this is the case. The differential ability of ANTXR1 and ANTXR2 to bind D683 mutant PA proteins was mapped to nonconserved receptor residues at the binding interface with PA domain 2. Moreover, a D683K mutant form of PA that bound specifically to human and rat ANTXR2 mediated killing of rats by anthrax lethal toxin, providing strong evidence for the physiological importance of ANTXR2 in anthrax disease pathogenesis

Diabetes-related molecular signatures in infrared spectra of human saliva

WOS: 000290261500001PubMed ID: 20630088Background: There is an ongoing need for improvements in non-invasive, point-of-care tools for the diagnosis and prognosis of diabetes mellitus. Ideally, such technologies would allow for community screening. Methods: In this study, we employed infrared spectroscopy as a novel diagnostic tool in the prediction of diabetic status by analyzing the molecular and sub-molecular spectral signatures of saliva collected from subjects with diabetes (n = 39) and healthy controls (n = 22). Results: Spectral analysis revealed differences in several major metabolic components - lipid, proteins, glucose, thiocyanate and carboxylate - that clearly demarcate healthy and diseased saliva. The overall accuracy for the diagnosis of diabetes based on infrared spectroscopy was 100% on the training set and 88.2% on the validation set. Therefore, we have established that infrared spectroscopy can be used to generate complex biochemical profiles in saliva and identify several potential diabetes-associated spectral features. Conclusions: Infrared spectroscopy may represent an appropriate tool with which to identify novel diseases mechanisms, risk factors for diabetic complications and markers of therapeutic efficacy. Further study into the potential utility of infrared spectroscopy as diagnostic and prognostic tool for diabetes is warranted

Nine-Banded Leper : Armadillos, Liminal Bodies, and Stigma in the United States

Senior Project submitted to The Division of Social Studies of Bard Colleg

Creative Editing

412 ha

Creative Editing International Edition

Buku ini mencakup semua aspek editing untuk media cetak dan online, dan menyediakan latihan praktek bagi siswa untuk menyempurnakan prinsip-prinsip dalam belajar mereka. Dimulai dari kemampuan bahasa dasar, hingga panduan fase pekerjaan copy editor profesional. Buku ini dilengkapi pula dengan area kerja yang menyediakan kerangka yang baik sehingga mendorong siswa untuk melatih kemampuan mereka