Il rinnovamento della parrocchia in una società che cambia. [Reseña]

Reseña de Lucio SORAVITO y Luca BRESSAN (eds.), Il rinnovamento della parrocchia in una società che cambia, Messaggero, Padova 2007, 157 pp., 14 x 21, ISBN 978-88-250-1719-9

Cholinoceptor Activation Subserving the Effects of Interferon Gamma on the Contractility of Rat Ileum

Recombinant rat interferon γ stimulated the contractility of isolated rat ileum at doses of 4–12 units/ml. Muscarinic cholinoceptors were involved, as treatment of the tissue with atropine prevented the contractile response of the ileum. Furthermore, interferon γ increased the affinity of carbachol for the cholinoceptors and did not change its maximum effect. Neurogenic pathways were also involved since pretreatment of ileum with hexamethonium, hemicholinium or tetrodotoxin impaired the contractile effect of interferon γ. In contrast to the action of exogenous carbachol, the effects of interferon γ are indirect. They appear to involve a G protein regulating phosphoinositide turnover and cytoskeletal structures since they could not be induced in ileum strips that were pretreated with pertussis toxin, phospholipase C inhibitors (2-nitro-carboxyphenyl, NN-diphenyl carbamate and neomycin), cytochalasine B or colchicine

Global vaccine safety blueprint: the landscape analysis (survey of regulators)

The perspectives of regulatory licensing authorities were assessed in countries that produce, procure, and both produce and procure vaccines. A web-based survey was developed to explore regulators’ knowledge, attitudes and practices concerning their national vaccine safety system. Additionally, their opinions about what would be needed to ensure future capacity and capabilities for a global vaccine safety system were probed, along with models of collaboration for regulatory authorities and the private sector that address public safety issues

Neisseria gonorrhoeae challenge increases matrix metalloproteinase-8 expression in fallopian tube explants

Indexación: Scopus.Background: Neisseria gonorrhoeae (Ngo) is the etiological agent of gonorrhea, a sexually transmitted infection that initially infects the female lower genital tract. In untreated women, the bacteria can ascend to the upper genital reproductive tract and infect the fallopian tube (FTs), which is associated with salpingitis and can lead to impaired FT function and infertility. The extracellular matrix (ECM) plays an important role in cell migration and differentiation in the female genital tract, and some pathogens modify the ECM to establish successful infections. The ECM is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), their endogenous inhibitors; MMP deregulation causes pathological conditions in a variety of tissues. Results: The aim of this work was to analyze the expression and localization of MMP-3, MMP-8, MMP-9, and TIMP-1 in FT explants during Ngo infection using real-time PCR, immunohistochemistry, zymography and ELISA. No significant variations in MMP-3, MMP-9, and TIMP-1 transcript levels were observed. In contrast, a significant increase (p < 0.05) was observed for MMP-8 expression and was accompanied by stromal immunoreactivity in infected explants. ELISA results supported these findings and showed that MMP-8 release increased upon gonococcal infection. Conclusions: Our results indicate that gonococcal infection induces increased MMP-8 expression, which might contribute to FT damage during infection. © 2017 Juica, Rodas, Solar, Borda, Vargas, Muñoz, Paredes, Christodoulides and Velasquez.https://www.frontiersin.org/articles/10.3389/fcimb.2017.00399/ful

Quantum Magnetic Impurities in Magnetically Ordered Systems

We discuss the problem of a spin 1/2 impurity immersed in a spin S magnetically ordered background. We show that the problem maps onto a generalization of the dissipative two level system (DTLS) with two independent heat baths, associated with the Goldstone modes of the magnet, that couple to different components of the impurity spin operator. Using analytical perturbative renormalization group (RG) methods and accurate numerical renormalization group (NRG) we show that contrary to other dissipative models there is quantum frustration of decoherence and quasi-scaling even in the strong coupling regime. We make predictions for the behavior of the impurity magnetic susceptibility that can be measured in nuclear magnetic resonance (NMR) experiments. Our results may also have relevance to quantum computation.Comment: 4 pages, 3 figure

Assisted hopping and interaction effects in impurity models

We study, using Numerical Renormalization Group methods, the generalization of the Anderson impurity model where the hopping depends on the filling of the impurity. We show that the model, for sufficiently large values of the assisted hopping term, shows a regime where local pairing correlations are enhanced. These correlations involve pairs fluctuating between on site and nearest neighbor positions