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Airborne environmental injuries and human health.
The concept that the environment in which we live can have detrimental effects on our health has existed for centuries. Obvious examples of substances that can cause human diseases include infectious agents, poisons, chemicals and other noxious agents, drugs, and physical stimuli such as bright lights and loud sounds. Some less obvious agents can include allergens, nontangible agents such as colorless, odorless gases and aerosolized toxins. In recent decades, humans have developed various new materials and compounds. Additionally, we are now producing known compounds, and even naturally occurring substances, in vastly increased amounts. Many of these substances are generally believed to threaten the health of our environment. However, there is also a considerable amount of hype and exaggeration regarding some of these agents (e.g., mold) that is unsubstantiated. This article extensively reviews the data on a large number of airborne-related illnesses and attempted to place scientific reality in the context of clinical medicine
Percolation of satisfiability in finite dimensions
The satisfiability and optimization of finite-dimensional Boolean formulas
are studied using percolation theory, rare region arguments, and boundary
effects. In contrast with mean-field results, there is no satisfiability
transition, though there is a logical connectivity transition. In part of the
disconnected phase, rare regions lead to a divergent running time for
optimization algorithms. The thermodynamic ground state for the NP-hard
two-dimensional maximum-satisfiability problem is typically unique. These
results have implications for the computational study of disordered materials.Comment: 4 pages, 4 fig
Wildlife population assessment : changing priorities driven by technological advances
TAM’s time for this review was covered under the ACCURATE project, funded by the US Navy Living Marine Resources program (contract no. N3943019C2176), and he also thanks partial support by CEAUL (funded by FCT—Fundação para a Ciência e a Tecnologia, Portugal, through the project UIDB/00006/2020).Advances in technology are having a large effect on the priorities for innovation in statistical ecology. Collaborations between statisticians and ecologists have always been important in driving methodological development, but increasingly, expertise from computer scientists and engineers is also needed. We discuss changes that are occurring and that may occur in the future in surveys for estimating animal abundance. As technology advances, we expect classical distance sampling and capture-recapture to decrease in importance, as camera (still and video) survey, acoustic survey, spatial capture-recapture and genetic methods continue to develop and find new applications. We explore how these changes are impacting the work of the statistical ecologist.Publisher PDFPeer reviewe
A hybrid constraint programming and semidefinite programming approach for the stable set problem
This work presents a hybrid approach to solve the maximum stable set problem,
using constraint and semidefinite programming. The approach consists of two
steps: subproblem generation and subproblem solution. First we rank the
variable domain values, based on the solution of a semidefinite relaxation.
Using this ranking, we generate the most promising subproblems first, by
exploring a search tree using a limited discrepancy strategy. Then the
subproblems are being solved using a constraint programming solver. To
strengthen the semidefinite relaxation, we propose to infer additional
constraints from the discrepancy structure. Computational results show that the
semidefinite relaxation is very informative, since solutions of good quality
are found in the first subproblems, or optimality is proven immediately.Comment: 14 page
Hypergraphic LP Relaxations for Steiner Trees
We investigate hypergraphic LP relaxations for the Steiner tree problem,
primarily the partition LP relaxation introduced by Koenemann et al. [Math.
Programming, 2009]. Specifically, we are interested in proving upper bounds on
the integrality gap of this LP, and studying its relation to other linear
relaxations. Our results are the following. Structural results: We extend the
technique of uncrossing, usually applied to families of sets, to families of
partitions. As a consequence we show that any basic feasible solution to the
partition LP formulation has sparse support. Although the number of variables
could be exponential, the number of positive variables is at most the number of
terminals. Relations with other relaxations: We show the equivalence of the
partition LP relaxation with other known hypergraphic relaxations. We also show
that these hypergraphic relaxations are equivalent to the well studied
bidirected cut relaxation, if the instance is quasibipartite. Integrality gap
upper bounds: We show an upper bound of sqrt(3) ~ 1.729 on the integrality gap
of these hypergraph relaxations in general graphs. In the special case of
uniformly quasibipartite instances, we show an improved upper bound of 73/60 ~
1.216. By our equivalence theorem, the latter result implies an improved upper
bound for the bidirected cut relaxation as well.Comment: Revised full version; a shorter version will appear at IPCO 2010
Methacholine-induced airway hyperresponsiveness is dependent on Gα\u3csub\u3eq\u3c/sub\u3e signaling
Airway function in health and disease as well as in response to bronchospastic stimuli (i.e., irritants, allergens, and inflammatory mediators) is controlled, in part, by cholinergic muscarinic receptor regulation of smooth muscle. In particular, the dependence of airway smooth muscle contraction/relaxation on heterotrimeric G protein-coupled receptor signaling suggests that these events underlie the responses regulating airway function. Gαq-containing G proteins are proposed to be a prominent signaling pathway, and the availability of knockout mice deficient of this subunit has allowed for an investigation of its potential role in airway function. Airway responses in Gαq-deficient mice (activities assessed by both tracheal tension and in vivo lung function measurements) were attenuated relative to wild-type controls. Moreover, ovalbumin sensitization/aerosol challenge of Gαq-deficient mice also failed to elicit an allergen-induced increase in airway reactivity to methacholine. These findings indicate that cholinergic receptor-mediated responses are dependent on Gαq-mediated signaling events and identify Gαq as a potential target of preventative/intervening therapies for lung dysfunction
QFT on homothetic Killing twist deformed curved spacetimes
We study the quantum field theory (QFT) of a free, real, massless and
curvature coupled scalar field on self-similar symmetric spacetimes, which are
deformed by an abelian Drinfel'd twist constructed from a Killing and a
homothetic Killing vector field. In contrast to deformations solely by Killing
vector fields, such as the Moyal-Weyl Minkowski spacetime, the equation of
motion and Green's operators are deformed. We show that there is a *-algebra
isomorphism between the QFT on the deformed and the formal power series
extension of the QFT on the undeformed spacetime. We study the convergent
implementation of our deformations for toy-models. For these models it is found
that there is a *-isomorphism between the deformed Weyl algebra and a reduced
undeformed Weyl algebra, where certain strongly localized observables are
excluded. Thus, our models realize the intuitive physical picture that
noncommutative geometry prevents arbitrary localization in spacetime.Comment: 23 pages, no figures; v2: extended discussion of physical
consequences, compatible with version to be published in General Relativity
and Gravitatio
First measurement of the Non-instantaneous response Time of a χ(3) nonlinear optical effect
The third harmonic of a few-cycle pulse, generated at different dielectric surfaces, is investigated using interferometric frequency-resolved optical gating. We present direct experimental evidence for a non-instantaneous nonlinear response in a TiO2 thin film whereas surface third-harmonic generation in a SiO2 sample does not show any indication for non-instanteneity. To the best of our knowledge, this constitutes the first report of a non-instantaneous nonlinear optical response of a dielectric optical material
Delta Doping of Ferromagnetism in Antiferromagnetic Manganite Superlattices
We demonstrate that delta-doping can be used to create a dimensionally
confined region of metallic ferromagnetism in an antiferromagnetic (AF)
manganite host, without introducing any explicit disorder due to dopants or
frustration of spins. Delta-doped carriers are inserted into a manganite
superlattice (SL) by a digital-synthesis technique. Theoretical consideration
of these additional carriers show that they cause a local enhancement of
ferromagnetic (F) double-exchange with respect to AF superexchange, resulting
in local canting of the AF spins. This leads to a highly modulated
magnetization, as measured by polarized neutron reflectometry. The spatial
modulation of the canting is related to the spreading of charge from the doped
layer, and establishes a fundamental length scale for charge transfer,
transformation of orbital occupancy and magnetic order in these manganites.
Furthermore, we confirm the existence of the canted, AF state as was predicted
by de Gennes [P.-G. de Gennes, Phys. Rev. 118, 141 (1960)], but had remained
elusive
The Pivotal Role of Causality in Local Quantum Physics
In this article an attempt is made to present very recent conceptual and
computational developments in QFT as new manifestations of old and well
establihed physical principles. The vehicle for converting the
quantum-algebraic aspects of local quantum physics into more classical
geometric structures is the modular theory of Tomita. As the above named
laureate to whom I have dedicated has shown together with his collaborator for
the first time in sufficient generality, its use in physics goes through
Einstein causality. This line of research recently gained momentum when it was
realized that it is not only of structural and conceptual innovative power (see
section 4), but also promises to be a new computational road into
nonperturbative QFT (section 5) which, picturesquely speaking, enters the
subject on the extreme opposite (noncommutative) side.Comment: This is a updated version which has been submitted to Journal of
Physics A, tcilatex 62 pages. Adress: Institut fuer Theoretische Physik
FU-Berlin, Arnimallee 14, 14195 Berlin presently CBPF, Rua Dr. Xavier Sigaud
150, 22290-180 Rio de Janeiro, Brazi
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