Guidelines and quality measures for the diagnosis of optic ataxia

Since the first description of a systematic mis-reaching by Balint in 1909, a reasonable number of patients showing a similar phenomenology, later termed optic ataxia (OA), has been described. However, there is surprising inconsistency regarding the behavioral measures that are used to detect OA in experimental and clinical reports, if the respective measures are reported at all. A typical screening method that was presumably used by most researchers and clinicians, reaching for a target object in the peripheral visual space, has never been evaluated. We developed a set of instructions and evaluation criteria for the scoring of a semi-standardized version of this reaching task. We tested 36 healthy participants, a group of 52 acute and chronic stroke patients, and 24 patients suffering from cerebellar ataxia. We found a high interrater reliability and a moderate test-retest reliability comparable to other clinical instruments in the stroke sample. The calculation of cut-off thresholds based on healthy control and cerebellar patient data showed an unexpected high number of false positives in these samples due to individual outliers that made a considerable number of errors in peripheral reaching. This study provides first empirical data from large control and patient groups for a screening procedure that seems to be widely used but rarely explicitly reported and prepares the grounds for its use as a standard tool for the description of patients who are included in single case or group studies addressing optic ataxia similar to the use of neglect, extinction, or apraxia screening tools

The recognition of everyday objects changes grasp scaling

AbstractCurrent concepts of action and perception emphasise a dissociation between conscious visual recognition and visual action control. These models do not expect an effect of the recognisable identity of an object on the kinematic parameterisation of grasping movements under binocular viewing conditions without pre-test learning periods. We performed two experiments presenting participants with familiar everyday objects or neutral geometrical objects. The participants grasped either with full vision or without visual feedback after movement onset without an explicit training phase before the experiment. In general, the familiarity of objects increased the sensitivity to physical object size changes measured by the slope of the maximal grip aperture relative to object size. We conclude that associations between object identity and a particular size, presumably encoded in long-term memory, are integrated in the parameterisation of grasping movements upon the identification of individual objects

Effects of pictorial cues on reaching depend on the distinctiveness of target objects.

There is an ongoing debate under what conditions learned object sizes influence visuomotor control under preserved stereovision. Using meaningful objects (matchboxes of locally well-known brands in the UK) a previous study has nicely shown that the recognition of these objects influences action programming by means of reach amplitude and grasp pre-shaping even under binocular vision. Using the same paradigm, we demonstrated that short-term learning of colour-size associations was not sufficient to induce any visuomotor effects under binocular viewing conditions. Now we used the same matchboxes, for which the familiarity effect was shown in the UK, with German participants who have never seen these objects before. We addressed the question whether simply a high degree of distinctness, or whether instead actual prior familiarity of these objects, are required to affect motor computations. We found that under monocular and binocular viewing conditions the learned size and location influenced the amplitude of the reaching component significantly. In contrast, the maximum grip aperture remained unaffected for binocular vision. We conclude that visual distinctness is sufficient to form reliable associations in short-term learning to influence reaching even for preserved stereovision. Grasp pre-shaping instead seems to be less susceptible to such perceptual effects

Towards audio-based distraction estimation in the car

Distraction of the driver is one of the most frequent causes for car accidents. We aim for a computational cognitive model predicting the driver’s degree of distraction during driving while performing a secondary task, such as talking with co-passengers. The secondary task might cognitively involve the driver to differing degrees depending on the topic of the conversation or the number of co-passengers. In order to detect these subtle differences in everyday driving situations, we aim to analyse in-car audio signals and combine this information with head pose and face tracking information. In the first step, we will assess driving, video and audio parameters reliably predicting cognitive distraction of the driver. These parameters will be used to train the cognitive model in estimating the degree of the driver’s distraction. In the second step, we will train and test the cognitive model during conversations of the driver with co-passengers during active driving. This paper describes the work in progress of our first experiment with preliminary results concerning driving parameters corresponding to the driver’s degree of distraction. In addition, the technical implementation of our experiment combining driving, video and audio data and first methodological results concerning the auditory analysis will be presented. The overall aim for the application of the cognitive distraction model is the development of a mobile user profile computing the individual distraction degree and being applicable also to other systems

Direct electrical stimulation of human cortex-the gold standard for mapping brain functions?

Despite its clinical relevance, direct electrical stimulation (DES) of the human brain is surprisingly poorly understood. Although we understand several aspects of electrical stimulation at the cellular level, surface DES evokes a complex summation effect in a large volume of brain tissue, and the effect is difficult to predict as it depends on many local and remote physiological and morphological factors. The complex stimulation effects are reflected in the heterogeneity of behavioural effects that are induced by DES, which range from evocation to inhibition of responses — sometimes even when DES is applied at the same cortical site. Thus, it is a misconception that DES — in contrast to other neuroscience techniques — allows us to draw unequivocal conclusions about the role of stimulated brain areas