Accelerator Measurements of Magnetically Induced Radio Emission from Particle Cascades with Applications to Cosmic-Ray Air Showers

For 50 years, cosmic-ray air showers have been detected by their radio emission. We present the first laboratory measurements that validate electrodynamics simulations used in air shower modeling. An experiment at SLAC provides a beam test of radio-frequency (rf) radiation from charged particle cascades in the presence of a magnetic field, a model system of a cosmic-ray air shower. This experiment provides a suite of controlled laboratory measurements to compare to particle-level simulations of rf emission, which are relied upon in ultrahigh-energy cosmic-ray air shower detection. We compare simulations to data for intensity, linearity with magnetic field, angular distribution, polarization, and spectral content. In particular, we confirm modern predictions that the magnetically induced emission in a dielectric forms a cone that peaks at the Cherenkov angle and show that the simulations reproduce the data within systematic uncertainties

GEMS: Galaxy Evolution from Morphologies and SEDs

GEMS, Galaxy Evolution from Morphologies and SEDs, is a large-area (800 arcmin2) two-color (F606W and F850LP) imaging survey with the Advanced Camera for Surveys on HST. Centered on the Chandra Deep Field South, it covers an area of ~28'x28', or about 120 Hubble Deep Field areas, to a depth of m_AB(F606W)=28.3 (5sigma and m_AB(F850LP)=27.1 (5sigma) for compact sources. In its central ~1/4, GEMS incorporates ACS imaging from the GOODS project. Focusing on the redshift range 0.2<=z<=1.1, GEMS provides morphologies and structural parameters for nearly 10,000 galaxies where redshift estimates, luminosities and SEDs exist from COMBO-17. At the same time, GEMS contains detectable host galaxy images for several hundred faint AGN. This paper provides an overview of the science goals, the experiment design, the data reduction and the science analysis plan for GEMS.Comment: 24 pages, TeX with 6 eps Figures; to appear in ApJ Supplement. Low resolution figures only. Full resolution at http://zwicky.as.arizona.edu/~rix/Misc/GEMS.ps.g

Design and Synthesis of Novel Quinone Inhibitors Targeted to the Redox Function of Apurinic/Apyrimidinic Endonuclease 1/Redox Enhancing Factor-1 (Ape1/Ref-1)

The multifunctional enzyme apurinic endonuclease 1/redox enhancing factor 1 (Ape1/ref-1) maintains genetic fidelity through the repair of apurinic sites and regulates transcription through redox-dependent activation of transcription factors. Ape1 can therefore serve as a therapeutic target in either a DNA repair or transcriptional context. Inhibitors of the redox function can be used as either therapeutics or novel tools for separating the two functions for in vitro study. Presently there exist only a few compounds that have been reported to inhibit Ape1 redox activity; here we describe a series of quinones that exhibit micromolar inhibition of the redox function of Ape1. Benzoquinone and naphthoquinone analogues of the Ape1-inhibitor E3330 were designed and synthesized to explore structural effects on redox function and inhibition of cell growth. Most of the naphthoquinones were low micromolar inhibitors of Ape1 redox activity, and the most potent analogues inhibited tumor cell growth with IC50 values in the 10−20 μM range

Evolution of optically faint AGN from COMBO-17 and GEMS

We have mapped the AGN luminosity function and its evolution between z=1 and z=5 down to apparent magnitudes of $R<24$. Within the GEMS project we have analysed HST-ACS images of many AGN in the Extended Chandra Deep Field South, enabling us to assess the evolution of AGN host galaxy properties with cosmic time.Comment: to appear in proceedings 'Multiwavelength AGN Surveys', Cozumel 200

The Munich-Evaluation-of-Mentoring-Questionnaire (MEMeQ) - a novel instrument for evaluating protégés' satisfaction with mentoring relationships in medical education

Background Despite the widespread recognition of the importance of mentoring in medical education, valid and reliable instruments for evaluating the relationship of mentors and protégés are lacking. The aim of this study was to develop a feasible instrument to measure the satisfaction with mentoring relationships. Methods Based on two existing questionnaires, the authors developed an instrument to evaluate the weighted satisfaction of mentoring relationships, emphasizing the protégés' individual expectations and needs. Protégés first define individual areas of interest in their mentoring relationship, then assign relative levels of personal importance to them and finally rate their individual level of satisfaction with their mentors' support in each area of interest. In order to evaluate psychometric properties as well as acceptance and feasibility the investigators conducted a multi-method-study. Results 134 protégés were included in the study. The instrument was neither perceived as distressing nor time-consuming. The two scores of the questionnaire correlated closely with the overall satisfaction regarding mentoring relationships (OSM, Rho: 0.66, p <.001 and Rho: 0.53, p < .001). Conclusions The authors propose MEMeQ as a reliable, valid and flexible instrument for measuring the weighted satisfaction of protégés with their individual mentoring relationship in medical education. Further research is needed to evaluate the generalizability of MEMeQ across other institutions and mentoring programs to add to its validity

Effective bioreduction of hexavalent chromium–contaminated water in fixed-film bioreactors

Hexavalent chromium (Cr6+) contamination from a dolomite stone mine in Limpopo Province, South Africa, has resulted in extensive groundwater contamination. In order to circumvent any further negative environmental impact at this site, an effective and sustainable treatment strategy for the removal of up to 6.49 mg/. Cr6+ from the groundwater was developed. Laboratory-scale, continuous up-flow bioreactors were constructed to  evaluate reduction of Cr6+, with a residence time of 24 h, an efficiency  porosity of 44% and a flow rate of 1.5 m./min. Stoichiometrically balancing terminal electron acceptors in the feed water with a selected electron donor, directed reactor balance for complete Cr6+ reduction. The microbial  community shifted in relative dominance during operation to establish an optimal metal-reducing community, including Enterobacter cloacae,  Flavobacterium sp. and Ralstonia sp., which achieved 100% reduction. Evaluation after reactor termination with SEM-EDX and XRD confirmed the establishment of biofilm on the reactor matrix, as well as trivalent  chromium (Cr3+) precipitation within the reactor. Due to gravitational force, high concentrations of Cr3+ were found in the bottom third of the reactor. Based on the results from the laboratory investigation, a 24 000 .  fixed-film pilot bioreactor was designed and constructed at this site. Influent flow rates, electron donor injection and automated sampling were remotely controlled by a programmable logic controller (PLC). Similar to the laboratory column study, steady state conditions could be achieved and successful Cr6+ reduction was evident. This is the first up-scaled, effective demonstration of a biological chromium(VI) bioremediation system in South Africa.Keywords: Bioreduction, fixed-film reactor, hexavalent chromium, microbial diversit

Dry Mergers in GEMS: The Dynamical Evolution of Massive Early-Type Galaxies

We have used the 28'x 28' HST image mosaic from the GEMS (Galaxy Evolution from Morphology and SEDs) survey in conjunction with the COMBO-17 photometric redshift survey to constrain the incidence of major mergers between spheroid-dominated galaxies with little cold gas (dry mergers) since z = 0.7. A set of N-body merger simulations was used to explore the morphological signatures of such interactions: they are recognizable either as < 5kpc separation close pairs or because of broad, low surface brightness tidal features and asymmetries. Data with the depth and resolution of GEMS are sensitive to dry mergers between galaxies with M_V < -20.5 for z < 0.7; dry mergers at higher redshifts are not easily recovered in single-orbit HST imaging. Six dry mergers (12 galaxies) with luminosity ratios between 1:1 and 4:1 were found from a sample of 379 red early-type galaxies with M_V < -20.5 and 0.1 < z < 0.7. The simulations suggest that the morphological signatures of dry merging are visible for ~250Myr and we use this timescale to convert the observed merger incidence into a rate. On this basis we find that present day spheroidal galaxies with M_V < -20.5 on average have undergone between 0.5 and 2 major dry mergers since z ~ 0.7. We have compared this result with the predictions of a Cold Dark Matter based semi-analytic galaxy formation model. The model reproduces the observed declining major merger fraction of bright galaxies and the space density of luminous early-type galaxies reasonably well. The predicted dry merger fraction is consistent with our observational result. Hence, hierarchical models predict and observations now show that major dry mergers are an important driver of the evolution of massive early-type galaxies in recent epochs.Comment: ApJ, in press. The paper has been extensively modified, detailing the automated+visual selection and dry merger classification. 11 pages emulateapj with 9 reduced-quality figures. A high quality copy is available at http://www.mpia-hd.mpg.de/homes/bell/papers/dry.ps.g

Cosmological weak lensing with the HST GEMS survey

We present our cosmic shear analysis of GEMS, one of the largest wide-field surveys ever undertaken by the Hubble Space Telescope. Imaged with the Advanced Camera for Surveys (ACS), GEMS spans 795 square arcmin in the Chandra Deep Field South. We detect weak lensing by large-scale structure in high resolution F606W GEMS data from ~60 resolved galaxies per square arcminute. We measure the two-point shear correlation function, the top-hat shear variance and the shear power spectrum, performing an E/B mode decomposition for each statistic. We show that we are not limited by systematic errors and use our results to place joint constraints on the matter density parameter Omega_m and the amplitude of the matter power spectrum sigma_8. We find sigma_8(Omega_m/0.3)^{0.65}=0.68 +/- 0.13 where the 1sigma error includes both our uncertainty on the median redshift of the survey and sampling variance. Removing image and point spread function (PSF) distortions are crucial to all weak lensing analyses. We therefore include a thorough discussion on the degree of ACS PSF distortion and anisotropy which we characterise directly from GEMS data. Consecutively imaged over 20 days, GEMS data also allows us to investigate PSF instability over time. We find that, even in the relatively short GEMS observing period, the ACS PSF ellipticity varies at the level of a few percent which we account for with a semi-time dependent PSF model. Our correction for the temporal and spatial variability of the PSF is shown to be successful through a series of diagnostic tests.Comment: 17 pages, 16 figures. Version accepted by MNRA

GEMS: Galaxy fitting catalogues and testing parametric galaxy fitting codes

In the context of measuring structure and morphology of intermediate redshift galaxies with recent HST/ACS surveys, we tune, test, and compare two widely used fitting codes (GALFIT and GIM2D) for fitting single-component Sersic models to the light profiles of both simulated and real galaxy data. We find that fitting accuracy depends sensitively on galaxy profile shape. Exponential disks are well fit with Sersic models and have small measurement errors, whereas fits to de Vaucouleurs profiles show larger uncertainties owing to the large amount of light at large radii. We find that both codes provide reliable fits and little systematic error, when the effective surface brightness is above that of the sky. Moreover, both codes return errors that significantly underestimate the true fitting uncertainties, which are best estimated with simulations. We find that GIM2D suffers significant systematic errors for spheroids with close companions owing to the difficulty of effectively masking out neighboring galaxy light; there appears to be no work around to this important systematic in GIM2D's current implementation. While this crowding error affects only a small fraction of galaxies in GEMS, it must be accounted for in the analysis of deeper cosmological images or of more crowded fields with GIM2D. In contrast, GALFIT results are robust to the presence of neighbors because it can simultaneously fit the profiles of multiple companions thereby deblending their effect on the fit to the galaxy of interest. We find GALFIT's robustness to nearby companions and factor of >~20 faster runtime speed are important advantages over GIM2D for analyzing large HST/ACS datasets. Finally we include our final catalog of fit results for all 41,495 objects detected in GEMS.Comment: Accepted for publication in ApJS October 2007, v172n2; 25 pages, 16 Figures, 9 Tables; for hi-resolution version, see http://www.mpia.de/homes/bhaeussl/galaxy_fitting.pdf. For results, catalogues and files for code-testing, see http://www.mpia.de/GEMS/fitting_paper.htm

Exploring the Impact of Galaxy Interactions over Seven Billion Years with CAS

We explore galaxy assembly over the last seven billion years by characterizing "normal" galaxies along the Hubble sequence, against strongly disturbed merging/interacting galaxies with the widely used CAS system of concentration (C), asymmetry (A), and 'clumpiness' (S) parameters, as well as visual classification. We analyze Hubble Space Telescope (HST) ACS images of ~4000 intermediate and high mass (> 10^9 solar masses) galaxies from the GEMS survey, one of the largest HST surveys conducted to date in two filters. We explore the effectiveness of the CAS criteria [A>S and A>~0.35] in separating normal and strongly disturbed galaxies at different redshifts, and quantify the recovery and contamination rate. We also compare the average star formation rate and the cosmic star formation rate density as a function of redshift between normal and interacting systems identified by CAS.Comment: ASP conference proceedings of 2007 Bash Symposium. Latex with asp2006.sty. 4 pages, 4 figure