Realisations of W3W_3 Symmetry

We perform a systematic investigation of free-scalar realisations of the Za\-mo\-lod\-chi\-kov $W_3$ algebra in which the operator product of two spin-three generators contains a non-zero operator of spin four which has vanishing norm. This generalises earlier work where such an operator was required to be absent. By allowing this spin-four null operator we obtain several realisations of the $W_3$ algebra both in terms of two scalars as well as in terms of an arbitrary number $n$ of free scalars. Our analysis is complete for the case of two-scalar realisations.Comment: 14 pages, LATEX, UG-6/9

A dendritic mechanism for decoding traveling waves: Principles and applications to motor cortex

Traveling waves of neuronal oscillations have been observed in many cortical regions, including the motor and sensory cortex. Such waves are often modulated in a task-dependent fashion although their precise functional role remains a matter of debate. Here we conjecture that the cortex can utilize the direction and wavelength of traveling waves to encode information. We present a novel neural mechanism by which such information may be decoded by the spatial arrangement of receptors within the dendritic receptor field. In particular, we show how the density distributions of excitatory and inhibitory receptors can combine to act as a spatial filter of wave patterns. The proposed dendritic mechanism ensures that the neuron selectively responds to specific wave patterns, thus constituting a neural basis of pattern decoding. We validate this proposal in the descending motor system, where we model the large receptor fields of the pyramidal tract neurons — the principle outputs of the motor cortex — decoding motor commands encoded in the direction of traveling wave patterns in motor cortex. We use an existing model of field oscillations in motor cortex to investigate how the topology of the pyramidal cell receptor field acts to tune the cells responses to specific oscillatory wave patterns, even when those patterns are highly degraded. The model replicates key findings of the descending motor system during simple motor tasks, including variable interspike intervals and weak corticospinal coherence. By additionally showing how the nature of the wave patterns can be controlled by modulating the topology of local intra-cortical connections, we hence propose a novel integrated neuronal model of encoding and decoding motor commands

The generation of hierarchic structures via robust 3D topology optimisation

Commonly used building structures often show a hierarchic layout of structural elements. It can be questioned whether such a layout originates from practical considerations, e.g. related to its construction, or that it is (relatively) optimal from a structural point of view. This paper investigates this question by using topology optimisation in an attempt to generate hierarchical structures. As an arbitrarily standard design case, the principle of a traditional timber floor that spans in one direction is used. The optimisation problem is first solved using classical sensitivity and density filtering. This leads indeed to solutions with a hierarchic layout, but they are practically unusable as the floor boarding is absent. A Heaviside projection is therefore considered next, but this does not solve the problem. Finally, a robust approach is followed, and this does result in a design similar to floor boarding supported by timber joists. The robust approach is then followed to study a floor with an opening, two floors that span in two directions, and an eight-level concrete building. It can be concluded that a hierarchic layout of structural elements likely originates from being optimal from a structural point of view. Also clear is that this conclusion cannot be obtained by means of standard topology optimisation based on sensitivity or density filtering (as often found in commercial finite element codes); robust 3D optimisation is required to obtain a usable, constructible (or in the future: 3D printable) structural design, with a crisp black-and-white density distribution

On realizing the bosonic string as a noncritical W3-string

We discuss a realization of the bosonic string as a noncritical $W_3$-string. The relevant noncritical $W_3$-string is characterized by a Liouville sector which is restricted to a (non-unitary) $(3,2)$ $W_3$ minimal model with central charge contribution $c_l = - 2$. Furthermore, the matter sector of this $W_3$-string contains $26$ free scalars which realize a critical bosonic string. The BRST operator for this $W_3$-string can be written as the sum of two, mutually anticommuting, nilpotent BRST operators: $Q = Q_0 + Q_1$ in such a way that the scalars which realize the bosonic string appear only in $Q_0$ while the central charge contribution of the fields present in $Q_1$ equals zero. We argue that, in the simplest case that the Liouville sector is given by the identity operator only, the $Q_1$-cohomology is given by a particular (non-unitary) $(3,2)$ Virasoro minimal model at $c=0$.Comment: 12 pages, UG-7/9

DARIS : a low-frequency distributed aperture array for radio astronomy in space

The frequency band below 30 MHz is one of the last unexplored bands in radio astronomy. This band is well suited for studying the early cosmos at high hydrogen redshifts, the so-called dark ages, extragalactic surveys, (extra) solar planetary bursts, and high energy particle physics. In addition, space research such as space weather tomography, are also areas of scientific interest. \ud \ud Due to ionospheric scintillation (below 30MHz) and its opaqueness (below 15MHz), earth-bound radio astronomy observations in these bands are either severely limited in sensitivity and spatial resolution or entirely impossible. A radio telescope in space obviously would not be hampered by the Earth's ionosphere. In the past, several (limited) studies have been conducted to explore possibilities for such an array in space. These studies considered aperture synthesis arrays in space, at the back-side of the Moon, or a satellite constellation operating in a coherent mode. \u

Systemic sclerosis: are anti-nuclear antibodies our guiding stars?

In this thesis the role of anti-nuclear antibodies to function as biomarkers in systemic sclerosis has been evaluated. Respectively, the heterogeneity of the disease, the need for biomarkers and the role of auto-antibodies to function as such, with specific attention for anti-topoisomerase I, have been outlined in this thesis. Boehringer Ingelheim; Chipsoft; Stichting NVLE fondsLUMC / Geneeskund

A two-stage thermal modification of wood

Thermal modification or heat treatment is an effective method to improve the dimensional stability and biological durability of wood. An undesired side effect is the reduction of mechanical properties of wood, mainly due to the high temperatures involved (150-280°C). In this thesis the effects of heat treatment on wood properties are discussed in relation to anatomical and molecular changes found in wood after heat treatment. The results are based on investigations of a full-scale industrial heat treatment method under relative mild conditions (< 200°C) including a moist and dry treatment stage. Several changes and/or modifications of the main components of wood (cellulose, hemicelluloses and lignin) appear to be involved in the effects of heat treatment on important wood properties like dimensional stability, strength/stiffness and biological durability. Although the effect of heat treatment on the anatomical structure of wood is limited, changes have been found affecting the properties of wood. This thesis provides a better understanding of thermal modification, which probably contributes to a more controlled use of heat-treated wood in service conditions