Modulation of Human Muscle Spindle Discharge by Arterial Pulsations - Functional Effects and Consequences

Arterial pulsations are known to modulate muscle spindle firing; however, the physiological significance of such synchronised modulation has not been investigated. Unitary recordings were made from 75 human muscle spindle afferents innervating the pretibial muscles. The modulation of muscle spindle discharge by arterial pulsations was evaluated by R-wave triggered averaging and power spectral analysis. We describe various effects arterial pulsations may have on muscle spindle afferent discharge. Afferents could be “driven” by arterial pulsations, e.g., showing no other spontaneous activity than spikes generated with cardiac rhythmicity. Among afferents showing ongoing discharge that was not primarily related to cardiac rhythmicity we illustrate several mechanisms by which individual spikes may become phase-locked. However, in the majority of afferents the discharge rate was modulated by the pulse wave without spikes being phase locked. Then we assessed whether these influences changed in two physiological conditions in which a sustained increase in muscle sympathetic nerve activity was observed without activation of fusimotor neurones: a maximal inspiratory breath-hold, which causes a fall in systolic pressure, and acute muscle pain, which causes an increase in systolic pressure. The majority of primary muscle spindle afferents displayed pulse-wave modulation, but neither apnoea nor pain had any significant effect on the strength of this modulation, suggesting that the physiological noise injected by the arterial pulsations is robust and relatively insensitive to fluctuations in blood pressure. Within the afferent population there was a similar number of muscle spindles that were inhibited and that were excited by the arterial pulse wave, indicating that after signal integration at the population level, arterial pulsations of opposite polarity would cancel each other out. We speculate that with close-to-threshold stimuli the arterial pulsations may serve as an endogenous noise source that may synchronise the sporadic discharge within the afferent population and thus facilitate the detection of weak stimuli

More on general pp-brane solutions

Recently it was found that the complete integration of the Einstein-dilaton-antisymmetric form equations depending on one variable and describing static singly charged $p$-branes leads to two and only two classes of solutions: the standard asymptotically flat black $p$-brane and the asymptotically non-flat $p$-brane approaching the linear dilaton background at spatial infinity. Here we analyze this issue in more details and generalize the corresponding uniqueness argument to the case of partially delocalized branes. We also consider the special case of codimension one and find, in addition to the standard domain wall, the black wall solution. Explicit relations between our solutions and some recently found $p$-brane solutions ``with extra parameters'' are presented.Comment: 29 pages, 2 figure

Immune mechanisms of vaccine induced protection against chronic hepatitis C virus infection in chimpanzees

Hepatitis C virus (HCV) infection is characterized by a high propensity for development of life-long viral persistence. An estimated 170 million people suffer from chronic hepatitis caused by HCV. Currently, there is no approved prophylactic HCV vaccine available. With the near disappearance of the most relevant animal model for HCV, the chimpanzee, we review the progression that has been made regarding prophylactic vaccine development against HCV. We describe the results of the individual vaccine evaluation experiments in chimpanzees, in relation to what has been observed in humans. The results of the different studies indicate that partial protection against infection can be achieved, but a clear correlate of protection has thus far not yet been defined

Hydrodynamics from the Dp-brane

We complete the computation of viscous transport coefficients in the near horizon geometries that arise from a stack of black Dp-branes for p=2,...,6 in the decoupling limit. The main new result is the obtention of the bulk viscosity which, for all p, is found to be related to the speed of sound by the simple relation \zeta/\eta = -2(v_s^2-1/p). For completeness the shear viscosity is rederived from gravitational perturbations in the shear and scalar channels. We comment on technical issues like the counterterms needed, or the possible dependence on the conformal frame.Comment: 15 page

The Conformal Penrose Limit and the Resolution of the pp-curvature Singularities

We consider the exact solutions of the supergravity theories in various dimensions in which the space-time has the form M_{d} x S^{D-d} where M_{d} is an Einstein space admitting a conformal Killing vector and S^{D-d} is a sphere of an appropriate dimension. We show that, if the cosmological constant of M_{d} is negative and the conformal Killing vector is space-like, then such solutions will have a conformal Penrose limit: M^{(0)}_{d} x S^{D-d} where M^{(0)}_{d} is a generalized d-dimensional AdS plane wave. We study the properties of the limiting solutions and find that M^{(0)}_{d} has 1/4 supersymmetry as well as a Virasoro symmetry. We also describe how the pp-curvature singularity of M^{(0)}_{d} is resolved in the particular case of the D6-branes of D=10 type IIA supergravity theory. This distinguished case provides an interesting generalization of the plane waves in D=11 supergravity theory and suggests a duality between the SU(2) gauged d=8 supergravity of Salam and Sezgin on M^{(0)}_{8} and the d=7 ungauged supergravity theory on its pp-wave boundary.Comment: 20 pages, LaTeX; typos corrected, journal versio

Thermodynamic Curvature of the BTZ Black Hole

Some thermodynamic properties of the Ba\~nados-Teitelboim-Zanelli (BTZ) black hole are studied to get the effective dimension of its corresponding statistical model. For this purpose, we make use of the geometrical approach to the thermodynamics: Considering the black hole as a thermodynamic system with two thermodynamic variables (the mass $M$ and the angular momemtum $J$), we obtain two-dimensional Riemannian thermodynamic geometry described by positive definite Ruppeiner metric. From the thermodynamic curvature we find that the extremal limit is the critical point. The effective spatial dimension of the statistical system corresponding to the near-extremal BTZ black holes is one. Far from the extremal point, the effective dimension becomes less than one, which leads to one possible speculation on the underlying structure for the corresponding statistical model.Comment: 19 pages, LaTeX with revtex macro, 4 figures in eps file