17 research outputs found
ChemInform Abstract: Modular, Flexible, and Stereoselective Synthesis of Pyrroloquinolines: Rapid Assembly of Complex Heterocyclic Scaffolds.
No full textChemInform Abstract: A Novel Three-Component [3 + 2] Cycloannulation Process for the Rapid and Highly Stereoselective Synthesis of Pyrrolobenzoxazoles.
No full textChemInform Abstract: A Highly Stereocontrolled, One-Pot Approach Toward Pyrrolobenzoxazinones and Pyrroloquinazolinones Through a Lewis Acid-Catalyzed [3 + 2]-Cycloannulation Process.
No full textA mild and efficient method for the one-pot monocarboxymethylation of primary amines
No full textA mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield
A Highly Stereocontrolled, One-Pot Approach toward Pyrrolobenzoxazinones and Pyrroloquinazolinones through a Lewis Acid-Catalyzed [3 + 2]-Cycloannulation Process
No full textWe report herein a stereocontrolled
[3 + 2]-cycloheteroannulation
of bis-silyl dienediolate <b>1</b> with 2-aminobenzoic acid-
and 2-aminobenzamide-derived imines to furnish highly substituted
pyrrolo[1,2-<i>a</i>]benzoxazinones <b>3</b> and pyrrolo[1,2-<i>a</i>]quinazolinones <b>4</b>, respectively, in good overall
yields. This one-pot process rapidly generates molecular complexity
and comprises a Lewis acid-catalyzed, vinylogous Mannich reaction
of <b>1</b> followed by an intramolecular <i>N</i>,<i>O</i>-acetal- and <i>N</i>,<i>N</i>-aminal formation, respectively, which proceeds with good to excellent
stereocontrol
A Highly Stereocontrolled, One-Pot Approach toward Pyrrolobenzoxazinones and Pyrroloquinazolinones through a Lewis Acid-Catalyzed [3 + 2]-Cycloannulation Process
No full textWe report herein a stereocontrolled
[3 + 2]-cycloheteroannulation
of bis-silyl dienediolate <b>1</b> with 2-aminobenzoic acid-
and 2-aminobenzamide-derived imines to furnish highly substituted
pyrrolo[1,2-<i>a</i>]benzoxazinones <b>3</b> and pyrrolo[1,2-<i>a</i>]quinazolinones <b>4</b>, respectively, in good overall
yields. This one-pot process rapidly generates molecular complexity
and comprises a Lewis acid-catalyzed, vinylogous Mannich reaction
of <b>1</b> followed by an intramolecular <i>N</i>,<i>O</i>-acetal- and <i>N</i>,<i>N</i>-aminal formation, respectively, which proceeds with good to excellent
stereocontrol
Highly Efficient Access to Both Geometric Isomers of Silyl Enol Ethers: Sequential 1,2-Brook/Wittig Reactions
No full text
