Intelligence: Knowns and Unknowns

In the fall of 1994, the publication of Herrnstein and Murray's book The Bell Curve sparked a new round of debate about the meaning of intelligence test scores and the nature of intelligence. The debate was characterized by strong assertions as well as by strong feelings. Unfortunately, those assertions often revealed serious misunderstandings of what has (and has not) been demonstrated by scientific research in this field. Although a great deal is now known, the issues remain complex and in many cases still unresolved. Another unfortunate aspect of the debate was that many participants made little effort to distinguish scientific issues from political ones. Research findings were often assessed not so much on their merits or their scientific standing as on their supposed political implications. In such a climate, individuals who wish to make their own judgments find it hard to know what to believe. Reviewing the intelligence debate at its meeting of November 1994, the Board of Scientific Affairs (BSA) of the American Psychological Association (APA) concluded that there was urgent need for an authoritative report on these issues--one that all sides could use as a basis for discussion. Acting by unanimous vote, BSA established a Task Force charged with preparing such a report. Ulri

Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients

Background: Altered pulmonary defenses in chronic obstructive pulmonary disease (COPD) may promote distal airways bacterial colonization. The expression/activation of Toll Like receptors (TLR) and beta 2 defensin (HBD2) release by epithelial cells crucially affect pulmonary defence mechanisms. Methods: The epithelial expression of TLR4 and of HBD2 was assessed in surgical specimens from current smokers COPD (s-COPD; n = 17), ex-smokers COPD (ex-s-COPD; n = 8), smokers without COPD (S; n = 12), and from non-smoker non-COPD subjects (C; n = 13). Results: In distal airways, s-COPD highly expressed TLR4 and HBD2. In central airways, S and s-COPD showed increased TLR4 expression. Lower HBD2 expression was observed in central airways of s-COPD when compared to S and to ex-s-COPD. s-COPD had a reduced HBD2 gene expression as demonstrated by real-time PCR on micro-dissected bronchial epithelial cells. Furthermore, HBD2 expression positively correlated with FEV1/FVC ratio and inversely correlated with the cigarette smoke exposure. In a bronchial epithelial cell line (16 HBE) IL-1β significantly induced the HBD2 mRNA expression and cigarette smoke extracts significantly counteracted this IL-1 mediated effect reducing both the activation of NFkB pathway and the interaction between NFkB and HBD2 promoter. Conclusions: This study provides new insights on the possible mechanisms involved in the alteration of innate immunity mechanisms in COPD. © 2012 Pace et al

A Tribute to the Mind, Methodology and Mentoring of Wayne Velicer

Wayne Velicer is remembered for a mind where mathematical concepts and calculations intrigued him, behavioral science beckoned him, and people fascinated him. Born in Green Bay, Wisconsin on March 4, 1944, he was raised on a farm, although early influences extended far beyond that beginning. His Mathematics BS and Psychology minor at Wisconsin State University in Oshkosh, and his PhD in Quantitative Psychology from Purdue led him to a fruitful and far-reaching career. He was honored several times as a high-impact author, was a renowned scholar in quantitative and health psychology, and had more than 300 scholarly publications and 54,000+ citations of his work, advancing the arenas of quantitative methodology and behavioral health. In his methodological work, Velicer sought out ways to measure, synthesize, categorize, and assess people and constructs across behaviors and time, largely through principal components analysis, time series, and cluster analysis. Further, he and several colleagues developed a method called Testing Theory-based Quantitative Predictions, successfully applied to predicting outcomes and effect sizes in smoking cessation, diet behavior, and sun protection, with the potential for wider applications. With $60,000,000 in external funding, Velicer also helped engage a large cadre of students and other colleagues to study methodological models for a myriad of health behaviors in a widely applied Transtheoretical Model of Change. Unwittingly, he has engendered indelible memories and gratitude to all who crossed his path. Although Wayne Velicer left this world on October 15, 2017 after battling an aggressive cancer, he is still very present among us

Evaluation of Asthma Control using Patient Based Measures and Peak Expiratory Flow Rate: " Evaluación del Control del Asma usando Medidas Basadas en el Paciente y Tasas de flujo Expiratorio Máximo"

Objective: Asthma control has not been formally evaluated in the Caribbean. This study evaluated disease control on The Asthma Control Test (ACT), The Royal College of Physicians “Three questions” for Assessing Asthma Control (RCP), peak expiratory flow rate (PEFR) and patients’ self-assessment of control. Subjects and Methods: Asthma control was examined in a cross-section of 205 asthmatics above 16 years of age using the ACT, RCP and on the PEFR % predicted. Scores below 20 and equal to or above 1 on the ACT and RCP respectively, and PEFR below 80% predicted indicated uncontrolled asthma. Patients stated whether they perceived their asthma was controlled or uncontrolled. Results: Overall there were more females (63.9%, p 0.05). Fewer patients (13.2%) achieved control on PEFR > 80% predicted than on the ACT (22.4%) and RCP (18%). The Kappa statistic indicated good reproducibility of the RCP and ACT and concordance between the PEFR and RCP (0.63) and the PEFR and ACT (0.56). Higher education was associated with control on the ACT (p 0.05). Conclusion: Approximately 80% of study asthmatics were uncontrolled, and patients tended to overestimate their disease control. The ACT and RCP instruments were comparable with the PEFR. Efforts to study their validity and formal evaluation of asthma control in Trinidad are recommended. RESUMEN Objetivo: El control del asma no ha sido evaluado formalmente en el Caribe. El estudio evaluó el control de la enfermedad utilizando el Test de Control del Asma (TCA), las “tres preguntas” del Colegio Real de Médicos para evaluar el control del asma (CRM), y la tasa de flujo expiratorio máximo (FEM) así como la autoevaluación del control por parte de los pacientes. Sujetos y métodos: El control del asma fue examinado en una sección transversal de 205 asmáticos de más de 16 años de edad, mediante el TCA, el CRM, y la predicción del FEM%. Las puntuaciones por debajo de 20 e iguales o por encima de 1 en el TCA y el CRM respectivamente, por debajo del 80% de predicción de la FEM, indicaban asma no controlada. Los pacientes informaban si percibían su asma como controlada o no controlada. Resultados: En general hubo más (p 0.05). Menos pacientes (13.2%) lograron un control con FEM > 80% de predicción que con TCA (22.4%) y CRM (18%). La estadística Kappa indicó una buena reproductibilidad de CRM y TCA, así como concordancia entre FEM y CRM (0.63) y FEM y TCA (0.56). Un nivel de educación más alto estuvo asociado con el control en TCA (p 0.05). Conclusión: Aproximadamente el 80% de los asmáticos fueron no controlados, y los pacientes sobrestiman su control de la enfermedad. Los instrumentos TCA y CRM fueron comparables con la FEM. Se recomienda hacer esfuerzos por estudiar la validez de estos, así como la evaluación formal del control del asma en Trinidad