Enoxaparin therapy for arterial thrombosis in infants with congenital heart disease

Objective: To investigate efficacy and safety of enoxaparin for catheter-related arterial thrombosis in infants with congenital heart disease. Design: Prospective observational study. Setting: Pediatric Intensive Care and Cardiology Unit at the University Children's Hospital of Zurich. Patients: Acohort of 32 infants aged 0-12 months treated with enoxaparin for catheter-related arterial thrombosis from 2002 to 2005. Measurements: Dose requirements of enoxaparin, resolution of thrombosis by Doppler ultrasound, and bleeding complications. Results: Catheter-related arterial thrombosis was located in the iliac/femoral arteries in 31 (97%) infants and aorta in 1 infant, and was related to indwelling catheters and cardiac catheterization in 17 (53%) and 15 (47%) cases, respectively. Newborns required increased doses of enoxaparin to achieve therapeutic anti-FXa levels (mean 1.62 mg/kg per dose) compared with infants aged 2-12 months (mean 1.12 mg/kg per dose; p = 0.0002). Complete resolution of arterial thrombosis occurred in 29 (91%) infants at amean of 23 days after initiation of enoxaparin therapy. Partial or no resolution was observed in 1 (3%) and 2 (6%) infants, respectively, at amean follow-up time of 4.3 months. Bleeding complications occurred in 1 (3%) infant. Conclusion: Enoxaparin is efficient and safe for infants with congenital heart disease and catheter-related arterial thrombosis, possibly representing avalid alternative to the currently recommended unfractionated hepari

Identification of two novel mutations in CDHR1 in consanguineous Spanish families with autosomal recessive retinal dystrophy.

Inherited retinal dystrophies present extensive phenotypic and genetic heterogeneity, posing a challenge for patients' molecular and clinical diagnoses. In this study, we wanted to clinically characterize and investigate the molecular etiology of an atypical form of autosomal recessive retinal dystrophy in two consanguineous Spanish families. Affected members of the respective families exhibited an array of clinical features including reduced visual acuity, photophobia, defective color vision, reduced or absent ERG responses, macular atrophy and pigmentary deposits in the peripheral retina. Genetic investigation included autozygosity mapping coupled with exome sequencing in the first family, whereas autozygome-guided candidate gene screening was performed by means of Sanger DNA sequencing in the second family. Our approach revealed nucleotide changes in CDHR1; a homozygous missense variant (c.1720C > G, p.P574A) and a homozygous single base transition (c.1485 + 2T > C) affecting the canonical 5' splice site of intron 13, respectively. Both changes co-segregated with the disease and were absent among cohorts of unrelated control individuals. To date, only five mutations in CDHR1 have been identified, all resulting in premature stop codons leading to mRNA nonsense mediated decay. Our work reports two previously unidentified homozygous mutations in CDHR1 further expanding the mutational spectrum of this gene

Procrastination : continuité de soi et projections mentales dans le futur

La procrastination, ou la tendance à remettre au lendemain, touche le quotidien de tout un chacun et notamment celui des étudiants. Les théories récentes sur ce phénomène suggèrent des liens entre la tendance générale à procrastiner, un faible sentiment de continuité du soi (Blouin-Hudon & Pychyl, 2015) et une façon moins riche et détaillée de se projeter mentalement dans le futur (Rebetez, Barsics, Rochat, D'Argembeau, & Van der Linden, 2016). Dans cette recherche, nous avons examiné et approfondi ces relations dans le contexte académique. Pour ce faire, nous avons administré à 108 étudiants âgés entre 20 et 53 ans, une tâche de projection mentale dans le futur ainsi que divers questionnaires (continuité de soi, procrastination et facteurs associés). Compte tenu des données de la littérature, les analyses statistiques ne confirment que partiellement nos attentes, ne montrant qu'un lien significatif (corrélation négative) avec les caractéristiques qualitatives des projections mentales..

Engineering economy, ed. 11/ Sullivan

xxi, 662 hal,: ill.; 24 c

Engineering economy, ed. 11/ Sullivan

xxi, 662 hal,: ill.; 24 c

Engineering economy

IndeksBibliografi hlm. 551xxi,662 hlm. : il. ; 25 cm

Ekonomi Teknik: Engineering Economy Tenth Edition

xvi+322hlm.;25c