Relationship Attitudes and Conflict Resolution Styles of Adult Children of Divorce

(Statement of Responsibility) by Bonnie Strelitz(Thesis) Thesis (B.A.) -- New College of Florida, 2003(Electronic Access) RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE(Bibliography) Includes bibliographical references.(Source of Description) This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.(Local) Faculty Sponsor: Barton, Michell

Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination

Multiple factors may be associated with immune responses to SARS-CoV-2 vaccines. Factors potentially related to magnitude and durability of response include age, time, and vaccine reactogenicity. This study analyzed SARS-CoV-2 IgG spike antibody responses following the second dose of vaccine in healthcare workers (HCWs). Data were collected from participants enrolled in a longitudinal SARS-CoV-2 serology study over a 12-month period. Participants completed a survey documenting symptoms post-vaccination. Serum specimens were tested for SARS-CoV-2 IgG antibodies using the Abbott Architect AdvisdeDx SARS-CoV-2 IgGII assay. Antibody levels were compared against time from second vaccine dose, and symptoms following vaccination. Altogether, 335 women (86.6%) and 52 men (13.4%) participated. Median age was 37 years (IQR 30-43). Overall median antibody level was 2150.80 [1246.12, 3556.98] AU/mL (IQR). Age was not associated with antibody concentration (p-value = 0.10). Higher antibody responses (2253 AU/mL vs. 1506 AU/mL; p = 0.008) were found in HCWs with one or more symptoms after the second dose of the vaccine (n = 311). Antibody responses persisted throughout the study period post-vaccination; statistically significant decreases in antibody responses were observed over time (p < 0.001). Higher antibody response was associated with reactogenicity post-vaccine. Age and sex were not associated with higher antibody responses

Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination

Multiple factors may be associated with immune responses to SARS-CoV-2 vaccines. Factors potentially related to magnitude and durability of response include age, time, and vaccine reactogenicity. This study analyzed SARS-CoV-2 IgG spike antibody responses following the second dose of vaccine in healthcare workers (HCWs). Data were collected from participants enrolled in a longitudinal SARS-CoV-2 serology study over a 12-month period. Participants completed a survey documenting symptoms post-vaccination. Serum specimens were tested for SARS-CoV-2 IgG antibodies using the Abbott Architect AdvisdeDx SARS-CoV-2 IgGII assay. Antibody levels were compared against time from second vaccine dose, and symptoms following vaccination. Altogether, 335 women (86.6%) and 52 men (13.4%) participated. Median age was 37 years (IQR 30-43). Overall median antibody level was 2150.80 [1246.12, 3556.98] AU/mL (IQR). Age was not associated with antibody concentration (p-value = 0.10). Higher antibody responses (2253 AU/mL vs. 1506 AU/mL; p = 0.008) were found in HCWs with one or more symptoms after the second dose of the vaccine (n = 311). Antibody responses persisted throughout the study period post-vaccination; statistically significant decreases in antibody responses were observed over time (p < 0.001). Higher antibody response was associated with reactogenicity post-vaccine. Age and sex were not associated with higher antibody responses

ELECTRONIC SCREENING FOR ADOLESCENT RISK BEHAVIORS IN THE EMERGENCY DEPARTMENT: A RANDOMIZED CONTROLLED TRIAL

ABSTRACT Introduction This study aimed to assess the prevalence of risk behaviors and the impact of electronic risk behavior screening with personalized feedback among adolescents seeking care in the emergency department (ED). Methods Randomized control trial of tablet-based screening and feedback among adolescents presenting to the ED. Intervention youth received screening with individualized feedback. Control youth completed risk behavior screening only. All participants received 3-month online follow up surveys re-assessing health behaviors. Results 296 subjects were enrolled and randomized. Approximately half were female (52.4%) and half white (54.4%) with a mean age of 15.4 years. The response rate at 3-month follow-up was 70.6%. &nbsp;The most frequently reported risk behaviors were those negatively impacting long-term health: sleeping less than 8 hours per night (142/296=48%), drinking more than 2 sugary drinks per day (99/296=33.4%) and getting less than 3 days of physical activity per week (96/296=32.4%). The prevalence of high-risk behaviors with more immediate health consequences were depression (92/296 =31.1%); high alcohol (47/296=15.9%) or marijuana use (55/296=18.6%); texting when driving (41/296=13.8%) and inconsistent birth control or condom use (42/296=14.2%). There was no significant difference between groups in risk behavior changes from baseline to 3 months. Conclusions While risk behavior prevalence was high in this population, electronic personalized feedback alone was insufficient to induce change in behaviors. More research is warranted to understand the best strategies for reducing risk among youth presenting to the ED

Disposable Autonomous Device for Swab-to-Result Diagnosis of Influenza

A prototype of a self-contained, automated, disposable device for chemically amplified protein-based detection of influenza virus from nasal swab specimens was developed and evaluated in a clinical setting. The device required only simple specimen manipulation without any dedicated instrumentation or specialized training by the operator for interpretation. The device was based on a sandwich immunoassay for influenza virus nucleoprotein; it used an enzyme-labeled antibody and a chromogenic substrate to provide an amplified visible signal, in a two-dimensional paper network format. All reagents were stored within the device. Device performance was assessed at Seattle Children’s Hospital; clinical staff collected nasal swab samples from 25 patients and then operated test devices on site to detect influenza A and B in those specimens. The total test time from device initiation to result was approximately 35 min. Device performance for influenza A detection was ∼70% accurate using in-house qRT-PCR influenza A as a gold-standard comparison. The ratio of valid to total completed device runs yielded a success rate of 92%, and the negative predictive value for both the influenza A and B assay was 81%. The ability to diagnose respiratory infections rapidly and close to the patient was well received by hospital staff, inspiring further optimization of device function