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Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature.
Fragile X syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and cognitive deficits, as well as populations with endocannabinoid deficiencies, such as those who suffer from FXS. The objective of this study was to provide a brief narrative review of recent literature on endocannabinoids and FXS and to present a case series describing three patients with FXS who were treated with oral CBD-enriched (CBD+) solutions. We review recent animal and human studies of endocannabinoids in FXS and present the cases of one child and two adults with FXS who were treated with various oral botanical CBD+ solutions delivering doses of 32.0 to 63.9 mg daily. Multiple experimental and clinical models of FXS combine to highlight the therapeutic potential of CBD for management of FXS. All three patients described in the case series exhibited functional benefit following the use of oral CBD+ solutions, including noticeable reductions in social avoidance and anxiety, as well as improvements in sleep, feeding, motor coordination, language skills, anxiety, and sensory processing. Two of the described patients exhibited a reemergence of a number of FXS symptoms following cessation of CBD+ treatment (e.g., anxiety), which then improved again after reintroduction of CBD+ treatment. Findings highlight the importance of exploring the therapeutic potential of CBD within the context of rigorous clinical trials
Frequency of Marijuana Use and Anxious and Fearful Responding to Bodily Sensations: a Laboratory Test
The current investigation examined the relation between frequency of marijuana use (no history of use, regular low-frequency use, and regular high-frequency use) and anxious and fearful responding to a biological challenge paradigm. Ninety-six participants (mage = 22.60, SD = 9.01, 45 females) were recruited from the greater Burlington, Vermont community and matched on gender, alcohol, and tobacco use. Primary results indicated that frequency of marijuana use was not significantly related to post-challenge panic attack symptoms, interest in returning for another challenge (behavioral avoidance), or changes in anxiety focused on bodily sensations, heart rate, or respiration rate (breaths per minute). Post hoc analyses suggested that, among current users of marijuana, those who were dependent on marijuana had greater panic attack symptoms post-challenge than those who abused marijuana. Further analyses indicated that, among current marijuana users, those who used the drug for coping reasons were significantly more likely to exhibit greater avoidance post-challenge as well as greater panic attack symptoms post-challenge than those who primarily used for other motives. Additionally, greater frequency of marijuana use among current users was related to less avoidance post-challenge. Findings of the investigation are discussed in relation to clarifying which factors of marijuana use may play a role in anxious and fearful responding to bodily sensations
Microwave Spectroscopy of Thermally Excited Quasiparticles in YBa_2Cu_3O_{6.99}
We present here the microwave surface impedance of a high purity crystal of
measured at 5 frequencies between 1 and 75 GHz. This data
set reveals the main features of the conductivity spectrum of the thermally
excited quasiparticles in the superconducting state. Below 20 K there is a
regime of extremely long quasiparticle lifetimes, due to both the collapse of
inelastic scattering below and the very weak impurity scattering in the
high purity -grown crystal used in this study. Above 20 K, the
scattering increases dramatically, initially at least as fast as .Comment: 13 pages with 10 figures. submitted to Phys Rev
Generalized Statistics and High Tc Superconductivity
Introducing the generalized, non-extensive statistics proposed by
Tsallis[1988], into the standard s-wave pairing BCS theory of superconductivity
in 2D yields a reasonable description of many of the main properties of high
temperature superconductors, provided some allowance is made for non-phonon
mediated interactions.Comment: 14 pages, 5 figure
Melting and Dimensionality of the Vortex Lattice in Underdoped YBa2Cu3O6.60
Muon spin rotation measurements of the magnetic field distribution in the
vortex state of the oxygen deficient high-Tc superconductor YBa{2}Cu{3}O{6.60}
reveal a vortex-lattice melting transition at much lower temperature than that
in the fully oxygenated material. The transition is best described by a model
in which adjacent layers of ``pancake'' vortices decouple in the liquid phase.
Evidence is also found for a pinning-induced crossover from a solid 3D to
quasi-2D vortex lattice, similar to that observed in the highly anisotropic
superconductor Bi{2+x}Sr{2-x}CaCu{2}O{8+y}.Comment: 8 pages, 4 figures, 5 postscript file
Outcomes in a community sex offender treatment program: A comparison between polygraphed and matched non-polygraphed offenders. Sexual Abuse: A
Abstract This study compared a group of 104 adult male sex offenders who received community cognitive-behavioral treatment, correctional supervision, and periodic polygraph compliance exams with a matched group of 104 sex offenders who received the same type of treatment and supervision services but no polygraph exams. Polygraph exams focused on whether participants were following their conditions of community supervision and treatment and had avoided committing new sexual offenses. The two groups were exact pair-wise matched on three variables: (1) Static-99 risk score (Hanson & Thornton 2000, Law and Human Behavior, 24, 119-136), (2) status as a completer of prison sex offender treatment, and (3) date placed in the community. At fixed 5-year follow-up periods, the number of individuals in the polygraph group charged with committing a new non-sexual violent offense was significantly lower than in the no polygraph group (2.9% versus 11.5%). However, there were no significant between-group differences for the number of individuals charged for new sexual (5.8% versus 6.7%), any sexual or violent (8.7% versus 16.3%), or any criminal offense (39.4% versus 34.6%). The results are discussed in terms of their clinical and research implications
Evidence for Static Magnetism in the Vortex Cores of Ortho-II YBaCuO
Evidence for static alternating magnetic fields in the vortex cores of
underdoped YBaCuO is reported. Muon spin rotation measurements
of the internal magnetic field distribution of the vortex state of
YBaCuO in applied fields of T and T reveal a
feature in the high-field tail of the field distribution which is not present
in optimally doped YBaCuO and which fits well to a model with
static magnetic fields in the vortex cores. The magnitude of the fields is
estimated to be 18(2) G and decreases above K. We discuss possible
origins of the additional vortex core magnetism within the context of existing
theories.Comment: Submitted to PRL; corresponding author: [email protected]
Background risk of breast cancer and the association between physical activity and mammographic density
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MRI investigation of granular interface rheology using a new cylinder shear apparatus
The rheology of granular materials near an interface is investigated through
proton magnetic resonance imaging. A new cylinder shear apparatus has been
inserted in the MRI device, which allows the control of the radial confining
pressure exerted by the outer wall on the grains and the measurement of the
torque on the inner shearing cylinder. A multi-layer velocimetry sequence has
been developed for the simultaneous measurement of velocity profiles in
different sample zones, while the measurement of the solid fraction profile is
based on static imaging of the sample. This study describes the influence of
the roughness of the shearing interface and of the transverse confining walls
on the granular interface rheology
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