Vulnerabilities Faced by Women Widowed by Kedarnath Disaster: An Explorative Case Study

This paper is aimed at exploring the vulnerabilities of women widowed during the Uttarakhand floods of India in 2013. Generally, widows in the Northern States of India, are perceived as a second-class citizen and is usually associated with social neglect, isolation, restrictions and poverty. The study consisted of 20 women who lost their husband in the floods. The results indicate that they are facing financial difficulties and profound helplessness. Their economic concerns primarily revolved around providing primary education and decent nutrition for their children. Governmental compensation and pension were reported to be insufficient to cover daily needs. Keywords: Widowhood; Vulnerability; Disaster; Floods eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bsby e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI3.253

A lattice of double wells for manipulating pairs of cold atoms

We describe the design and implementation of a 2D optical lattice of double wells suitable for isolating and manipulating an array of individual pairs of atoms in an optical lattice. Atoms in the square lattice can be placed in a double well with any of their four nearest neighbors. The properties of the double well (the barrier height and relative energy offset of the paired sites) can be dynamically controlled. The topology of the lattice is phase stable against phase noise imparted by vibrational noise on mirrors. We demonstrate the dynamic control of the lattice by showing the coherent splitting of atoms from single wells into double wells and observing the resulting double-slit atom diffraction pattern. This lattice can be used to test controlled neutral atom motion among lattice sites and should allow for testing controlled two-qubit gates.Comment: 9 pages, 11 figures Accepted for publication in Physical Review

Watershed regulation and local action: analysis of the Senegal River watershed management by a regional organisation and public participation

International audienceSeveral social scientists have dealt with the usefulness of a participative approach in development plans. The call for sustainable development has increased the focus on this type of approach in a very classical way, which is the case for the creation of new water tanks. Most of these scientists have also pinpointed the major difficulties and failures faced during the execution of this new approach in developing countries. This study is a concrete example which underlines the lack of this type of approach as far as water management in the Senegal River is concerned, mainly in relation to watershed. We base our study on the analysis and criticism of the regional organization OMVS (Organization for the Development of the Senegal River) which is in charge of water management in the Senegal River. The results of the study can, therefore, be summed up as follows: (i) An on-site direct observation, individual interviews, group discussion and information analysis point out the lack of participation of local people in water management in the Senegal River and, in general, the harmful socio-economic impacts resulting from it. (ii) The reasons for this lack of participative approach are mainly due to the model set up by the OMVS in terms of water management in the Senegal River, a model that has excluded or tackled in a very light way the issue of public participation in decision-making through out its juridical and regulation instruments. (iii) Elements of consideration on some measures, which could possibly improve the level of participation of local people in river water management

In stage II/III lymph node positive breast cancer patients less than 55 years of age, keratin 8 expression in lymph node metastases but not in the primary tumor is an indicator of better survival

Axillary lymph node status is one of the most important prognostic variables for breast cancer (BC). To investigate and understand the clinical, histopathological and biological factors that affect prognosis in node positive young breast cancer patients, we compared the phenotype of 100 primary tumours with their corresponding loco- regional lymph node (LN) metastases using conventional immunohistochemistry (IHC) markers currently in use for molecular classification of breast cancer. By comparing the expression of ER, PR, HER-2, Ki67, K8, K5/6 and vimentin, we found that expression of HER-2, Ki67, K8 and vimentin is frequently lost in lymph node metastases. Between the primary tumour and corresponding lymph node metastases expression of keratins K8 and K5/6 significantly changed. Expression of K8 in lymph node metastases, but not in primary tumours, segregates patients in two sub-groups with different outcome. Survival of patients with K8 positive LN metastases at 5 years in comparison with patients with K8 negative LN metastases was 75% vs 48%, at 10 years 62% vs 22% and at 20 years 53% vs 14%(p<0.001). K8 immunostaining of tissue from the lymph node metastasis allows defining a sub-group of lymph node positive BC patients with a highly unfavourable outcome, for whom therapeutic options might have to be reconsidered

Attosecond tracking of light absorption and refraction in fullerenes

The collective response of matter is ubiquitous and widely exploited, e.g. in plasmonic, optical and electronic devices. Here we trace on an attosecond time scale the birth of collective excitations in a finite system and find distinct new features in this regime. Combining quantum chemical computation with quantum kinetic methods we calculate the time-dependent light absorption and refraction in fullerene that serve as indicators for the emergence of collective modes. We explain the numerically calculated novel transient features by an analytical model and point out the relevance for ultra-fast photonic and electronic applications. A scheme is proposed to measure the predicted effects via the emergent attosecond metrology.Comment: 11 pages, 3 figures, accepted in Phys. Rev.

Tumour heterogeneity: principles and practical consequences

Two major reasons compel us to study tumour heterogeneity: firstly, it represents the basis of acquired therapy resistance, and secondly it may be one of the major sources of the low level of reproducibility in clinical cancer research. The present review focuses on the heterogeneity of neoplastic disease, both within the primary tumour, and between primary tumour and metastases. We discuss different levels of heterogeneity and the current understanding of the phenomenon, as well as imminent developments relevant for clinical research and diagnostic pathology. It is necessary to develop new tools to study heterogeneity and new biomarkers for heterogeneity. Established and new in situ methods will be very useful. In future studies, not only clonal heterogeneity needs to be addressed, but also non-clonal phenotypic heterogeneity which might be important for therapy resistance. We also review heterogeneity established in major tumour types, in order to explore potential similarities that might help to define new strategies for targeted therapy

Colossal magnetoresistance in an ultra-clean weakly interacting 2D Fermi liquid

We report the observation of a new phenomenon of colossal magnetoresistance in a 40 nm wide GaAs quantum well in the presence of an external magnetic field applied parallel to the high-mobility 2D electron layer. In a strong magnetic field, the magnetoresistance is observed to increase by a factor of ~300 from 0 to 45T without the system undergoing any metal-insulator transition. We discuss how this colossal magnetoresistance effect cannot be attributed to the spin degree-of-freedom or localization physics, but most likely emanates from strong magneto-orbital coupling between the two-dimensional electron gas and the magnetic field. Our observation is consistent with a field-induced 2D-to-3D transition in the confined electronic system

The Impact of Telemedicine in the Diagnosis of Erythema Migrans during the COVID Pandemic: A Comparison with In-Person Diagnosis in the Pre-COVID Era

Background: Erythema migrans (EM) is the hallmark manifestation of the Lyme borreliosis (LB), and therefore its presence and recognition are sufficient to make a diagnosis and to start proper antibiotic treatment to attempt to eradicate the infection. Methods: In this study we compared the clinical data of 439 patients who presented an EM either according to the diagnostic modality through physical assessment or through telemedicine. Conclusions: Our data clearly show that telemedicine for EM diagnosis is useful as it enables prompt administration of appropriate antibiotic therapy, which is critical to avoid complications, especially for neurologic and articular entities. Therefore, telemedicine is a tool that could be adopted for the diagnosis of Lyme disease both by specialized centers but also by general practitioners

PI3K/AKT Signaling in Breast Cancer Molecular Subtyping and Lymph Node Involvement

Lymph node metastatic involvement persists to be among the most important predictors of recurrence and survival in breast carcinoma (BC). This study aimed at investigating possible gene expression differences in primary BC between patients with or without lymph node involvement at the time of diagnosis. In a retrospective study, we investigated the potential prognostic role of 9 candidate biomarkers at mRNA level in a cohort of 305 breast cancer patients, 151 lymph node-negative (LN-) and 154 lymph node-positive (LN+). The analyzed genes belonged to the RAS pathway (RAF1, ERBB2, PIK3CB, AKT1, AKT2, AKT3), RB pathway (RB1 and CDK2) and cellular differentiation (KTR8). Their expression profiles were investigated by RT-qPCR and were correlated to immunohistochemically-based molecular subtypes and BC clinical and pathological features. The differential expression of several genes in the primary tumor tissue was related to the LN involvement. Some of those genes, including PIK3CB, RB1, and AKT3, were more expressed in LN- BC patients, while some others, notably ERBB2 and AKT1, in LN+ ones. Among the candidate biomarkers, the expression levels of AKTs isoforms influenced also patients\u2019 survival rates. In detail, higher expression levels of AKT1 and AKT2 negatively influenced overall patients\u2019 survival and in particular AKT2 expression levels defined a group of luminal B BC patients with shorter cancer-specific survival. On the contrary, longer cancer-specific survival was recorded in luminal A BC patients with higher expression levels of AKT3. That finding was also confirmed by Cox multivariate analysis. The same AKT3 resulted to be a possible candidate predictive biomarker for Tamoxifen response. In conclusion, our study highlighted the complex regulation of the PI3K/AKT pathway in BC and its differences in BC patients with and without lymph node involvement