779 research outputs found
Molecular features of low-grade developmental brain tumours:Focusing on subependymal giant cell astrocytomas in tuberous sclerosis complex
CA2 Pyramidal Layer
This report contains a gene expression summary of the CA2 pyramidal cell layer (CA2sp), derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the CA2sp were compared to the values of the macro/parent-structure, in this case the pyramidal layer of Ammon’s Horn, for the purpose of extracting regionally selective gene expression data. The genes with the highest ranking selectivity ratios were manually curated and verified. 50 genes were then selected and compiled for expression characterization. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the CA2sp and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report
Facial Motor Nucleus
This report contains a summary of expression patterns for genes that are enriched in the facial motor nucleus (VII) of the medulla. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the facial motor nucleus were compared to the values of its larger parent structure, in this case the medulla, for the purpose of extracting regionally selective gene expression data. The highest ranking genes were manually curated and verified. 50 genes were then selected and compiled for expression analysis. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the facial motor nucleus and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report
Dentate Gyrus
This report contains a gene expression summary of the dentate gyrus (DG), derived from the Allen Brain Atlas (ABA) _in situ_ hybridization mouse data set. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the dentate gyrus were compared to the values of the macro/parent-structure, in this case the hippocampal region, for the purpose of extracting regionally selective gene expression data. The genes with the highest ranking selectivity ratios were manually curated and verified. 50 genes were then selected and compiled for expression characterization. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the dentate gyrus and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report
Motor Nucleus of the Trigeminal Nerve
This report contains a summary of expression patterns for genes that are enriched in the motor nucleus of the trigeminal nerve (V) of the pons. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the motor nucleus of the trigeminal nerve were compared to the values of its larger parent structure, in this case the pons, for the purpose of extracting regionally selective gene expression data. The highest ranking genes were manually curated and verified. 50 genes were then selected and compiled for expression analysis. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the motor nucleus of the trigeminal nerve and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report. 

Bohmian trajectories and Klein's paradox
We compute the Bohmian trajectories of the incoming scattering plane waves
for Klein's potential step in explicit form. For finite norm incoming
scattering solutions we derive their asymptotic space-time localization and we
compute some Bohmian trajectories numerically. The paradox, which appears in
the traditional treatments of the problem based on the outgoing scattering
asymptotics, is absent.Comment: 14 pages, 3 figures; minor format change
Proximate determinants of fertility in Ethiopia: comparative analysis of the 2005 and 2011 DHS
Fertility is one of the elements in population dynamics that makes a significant contribution towards changing population size and structure over time. In Ethiopia, for the last 10 years the total fertility rate (TFR) has declined slightly from 5.5 to 4.8 children in 2011. But, the TFR in urban areas has increased from 2.4 to 2.6 per 1000 live births. The Bongaarts model was applied to estimate the indices of the four main proximate determinants of fertility. Bongaarts defines the TFR of a population as a function of the total fecundity rate (TF), index of marriage (Cm), index of contraception (Cc), index of postpartum infecundability (Ci), and index of abortion (Ca); this can be written as TFR = Cm × Cc × Ci × Ca × TF. In 2005, the index of married women in urban areas was lower than rural, but it was unfortunately the same in urban and rural areas in 2011. For the last decade, the index of postpartum infecundability had a great fertility reduction effect compared with the contraception index and marriage index in rural Ethiopia. The lower the four indices of proximate determinants, the more fertility will be reduced. As such, the Ethiopian government, international non-governmental organizations and policy-makers must pay attention to increase the prevalence of contraceptive use and educate society to fight against child marriage. Permanent contraceptive use, such as female sterilization, should be promoted; moreover, legal organizations and the community must work together to raise the legal age of marriage to 18 years.IS
The linked survival prospects of siblings : evidence for the Indian states
This paper reports an analysis of micro-data for India that shows a high correlation in infant mortality
among siblings. In 13 of 15 states, we identify a causal effect of infant death on the risk of infant death of the
subsequent sibling (a scarring effect), after controlling for mother-level heterogeneity. The scarring effects
are large, the only other covariate with a similarly large effect being mother’s (secondary or higher)
education. The two states in which evidence of scarring is weak are Punjab, the richest, and Kerala, the
socially most progressive. The size of the scarring effect depends upon the sex of the previous child in three
states, in a direction consistent with son-preference. Evidence of scarring implies that policies targeted at
reducing infant mortality will have social multiplier effects by helping avoid the death of subsequent
siblings. Comparison of other covariate effects across the states offers some interesting new insights
Consensus and contention in the priority setting process: examining the health sector in Uganda.
Health priority setting is a critical and contentious issue in low-income countries because of the high burden of disease relative to the limited resource envelope. Many sophisticated quantitative tools and policy frameworks have been developed to promote transparent priority setting processes and allocative efficiency. However, low-income countries frequently lack effective governance systems or implementation capacity, so high-level priorities are not determined through evidence-based decision-making processes. This study uses qualitative research methods to explore how key actors' priorities differ in low-income countries, using Uganda as a case study. Human resources for health, disease prevention and family planning emerge as the common priorities among actors in the health sector (although the last of these is particularly emphasized by international agencies) because of their contribution to the long-term sustainability of health-care provision. Financing health-care services is the most disputed issue. Participants from the Ugandan Ministry of Health preferentially sought to increase net health expenditure and government ownership of the health sector, while non-state actors prioritized improving the efficiency of resource use. Ultimately it is apparent that the power to influence national health outcomes lies with only a handful of decision-makers within key institutions in the health sector, such as the Ministries of Health, the largest bilateral donors and the multilateral development agencies. These power relations reinforce the need for ongoing research into the paradigms and strategic interests of these actors
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