An S

Aronica E.

Bongaarts A

Bucur S

Honavar M

Jacques T

Jäger HR

Liu J

Marsdon D

McEvoy A

Miserocchi A

Newman F

Paradiso B

Reeves C

Reinten RJ

Somani A

Thom M

Thorne L

English

Multinodular and vacuolating neuronal tumor (MVNT) is a new pattern of neuronal tumour included in the recently revised WHO 2016 classification of tumors of the CNS. There are 15 reports in the literature to date. They are typically associated with late onset epilepsy and a neoplastic vs. malformative biology has been questioned. We present a series of ten cases and compare their pathological and genetic features to better characterized epilepsy-associated malformations including focal cortical dysplasia type II (FCDII) and low-grade epilepsy-associated tumors (LEAT). Clinical and neuroradiology data were reviewed and a broad immunohistochemistry panel was applied to explore neuronal and glial differentiation, interneuronal populations, mTOR pathway activation and neurodegenerative changes. Next generation sequencing was performed for targeted multi-gene analysis to identify mutations common to epilepsy lesions including FCDII and LEAT. All of the surgical cases in this series presente..

Jäger HR

Archivio istituzionale della ricerca - Università di Padova

Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?

https://www.research.unipd.it/bitstream/11577/3277546/2/BP%20Thom2017.pdf

Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?

Abstract

Similar works

Full text

Available Versions

Archivio istituzionale della ricerca - Università di Padova