Uncertainty In Radar-rainfall Composite And Its Impact On Hydrologic Prediction For The Eastern Iowa Flood Of 2008

Key Points A significant potential source of error exists in mosaicked radar-rainfall maps. Different radar calibration offsets lead to misestimation of rainfall amounts. Systematic error in rainfall significantly affects hydrologic predictions. This study addresses a significant potential source of error that exists in radar-rainfall maps that are combined using data from multiple WSR-88D radars of the Next Generation Radar (NEXRAD) national network in the United States. This error stems from different radar calibration offsets that create a border within discontinuous rainfall fields at the equidistance zone among radars. The discontinuity in rainfall fields could lead to misestimation of rainfall over basins and subsequently, to significant errors in streamflow predictions through a hydrologic model. In this study, we produce enhanced radar-rainfall estimates (HN3) based on a novel approach that allows us to reduce the effects of the relative radar calibration bias. We use the relative bias information previously presented in a radar reflectivity comparison study. To investigate the effects of the relative bias adjustment, we evaluate the HN3 and Stage IV radar-rainfall by comparing them with rain gauge data and analyzing their ability to simulate streamflow for an extreme flood case. While the HN3 estimates are statistically comparable to the Stage IV estimates in the rain gauge data comparison, the borderline that identifies discontinuous rainfall fields disappears in the HN3 estimates. We performed hydrological simulations using a physically based, data-intensive, calibration-free, hillslope-link hydrologic model called CUENCAS and demonstrated CUENCAS\u27s ability to accurately simulate flows by comparing results with observed and predicted streamflow generated by the Sacramento (SAC) model. SAC is the operational flood forecast model that has been used by the National Weather Service since 1969, and it was extensively calibrated based on historical data. The simulation results show that the adjustment improves streamflow predictions in the regions where the misestimation of rainfall quantity is considerable. We conclude that systematic error arising from different calibration offsets in rainfall fields can significantly affect hydrologic predictions. ©2013. American Geophysical Union. All Rights Reserved

Inter-comparison Of Reflectivity Measurements Between GPM DPR And NEXRAD Radars

This study demonstrates the potential use of the NASA\u27s Global Precipitation Measurement (GPM) Dual-frequency Precipitation Radar (DPR) to examine ground radar (GR) miscalibration and other uncertainty sources (e.g., partial beam blockage). We acquired the GPM Ground Validation System Validation Network reflectivity matchups between the DPR and three GRs (two in Iowa and one in South Dakota) for 2014–2017. We then refined the matching parameters (e.g., time separation) to reduce uncertainty in the matchup samples by analyzing the sensitivity of the matchup statistical properties to changes in these parameters. To reconcile the same observables (i.e., reflectivity) with different observational properties among the space- and ground-based radars, we developed a statistically integrated framework using inter-comparisons of them all with a Monte Carlo simulation. This method verifies the absolute calibration bias estimated from the refined DPR–GR matchups using relative calibration biases between GRs. We found that taking samples with a narrow temporal gap, estimated by actual measurement time of the DPR and GRs, can significantly reduce sample variability. Through inter-comparisons among the DPR and GRs, we observed that reflectivity differences among GRs in a similar environment (e.g., climatology and geography) are likely to be affected primarily by the calibration mismatch. In this case, the inter-comparison results demonstrated good agreement, and we inferred that the differences can be mitigated by calibration bias correction against the DPR. On the other hand, when the disagreement level of the inter-comparison results is significant, the authors found that other factors, such as partial beam blockage even in relatively plain regions, are more dominant than the calibration bias. In fact, the partial beam blockage effects can manifest themselves as a seasonal pattern in the GR inter-comparison results

Comprehensive Evaluation Of The IFloodS Radar Rainfall Products For Hydrologic Applications

This study describes the generation and testing of a reference rainfall product created from field campaign datasets collected during the NASA Global Precipitation Measurement (GPM) mission Ground Validation Iowa Flood Studies (IFloodS) experiment. The study evaluates ground-based radar rainfall (RR) products acquired during IFloodS in the context of building the reference rainfall product. The purpose of IFloodS was not only to attain a high-quality ground-based reference for the validation of satellite rainfall estimates but also to enhance understanding of flood-related rainfall processes and the predictability of flood forecasting. We assessed the six RR estimates (IFC, Q2, CSU-DP, NWS-DP, Stage IV, and Q2-Corrected) using data from rain gauge and disdrometer networks that were located in the broader field campaign area of central and northeastern Iowa. We performed the analyses with respect to time scales ranging from 1 h to the entire campaign period in order to compare the capabilities of each RR product and to characterize the error structure at scales that are frequently used in hydrologic applications. The evaluation results show that the Stage IV estimates perform superior to other estimates, demonstrating the need for gauge-based bias corrections of radar-only products. This correction should account for each product\u27s algorithm-dependent error structure that can be used to build unbiased rainfall products for the campaign reference. We characterized the statistical error structures (e.g., systematic and random components) of each RR estimate and used them for the generation of a campaign reference rainfall product. To assess the hydrologic utility of the reference product, we performed hydrologic simulations driven by the reference product over the Turkey River basin. The comparison of hydrologic simulation results demonstrates that the campaign reference product performs better than Stage IV in streamflow generation

Towards better utilization of NEXRAD data in hydrology: An overview of hydro-NEXRAD

With a very modest investment in computer hardware and the open-source local data manger (LDM) software from UCAR\u27s Unidata Program Center, an individual researcher can receive a variety of NEXRAD Level III gridded rainfall products, and the unprocessed Level II data in real-time from most NEXRAD radars. Additionally, the National Climatic Data Center has vast archives of these products and Level II data. Still, significant obstacles remain in order to unlock the full potential of the data. One set of obstacles is related to effective management of multi-terabyte data sets: storing, compressing, and backing up. A second set of obstacles, for hydrologists and hydrometeorologists in particular, is that the NEXRAD Level III products are not well suited for application in hydrology. There is a strong need for the generation of high-quality products directly from the Level II data with well-documented steps that include quality control, removal of false echoes, rainfall estimation algorithms with variety of corrections, coordinate conversion and georeferencing, conversion to a convenient data format(s), and integration with GIS. For hydrologists it is imperative that these procedures are basin-centered as opposed to radar-centered. Thirdly, the amount of data present in a multi-year, multi-radar dataset is such that simple cataloging and indexing of the data is not sufficient. Rather, sophisticated metadata extraction and management techniques are required. The authors describe and discuss the Hydro-NEXRAD software system that addresses the above three challenges. With support from the National Science Foundation through its ITR program, the authors are developing a basin-centered framework for addressing all these issues in a comprehensive manner, tailored specifically for use of NEXRAD data in hydrology and hydrometeorology. Through a flexible web interface users can search a large metadata database base, managed by a relational database, for subsets of interest. Well-chosen and documented defaults are provided for the flow from unprocessed NEXRAD data to basin-centered rainfall estimates at a desired space-time resolution. In addition to the web interface, there are web services that provide access to scripts and compiled programs. © 2007 ASCE

EGb761, a Ginkgo Biloba Extract, Is Effective Against Atherosclerosis In Vitro, and in a Rat Model of Type 2 Diabetes

BACKGROUND: EGb761, a standardized Ginkgo biloba extract, has antioxidant and antiplatelet aggregation and thus might protect against atherosclerosis. However, molecular and functional properties of EGb761 and its major subcomponents have not been well characterized. We investigated the effect of EGb761 and its major subcomponents (bilobalide, kaemferol, and quercetin) on preventing atherosclerosis in vitro, and in a rat model of type 2 diabetes. METHODS AND RESULTS: EGb761 (100 and 200 mg/kg) or normal saline (control) were administered to Otsuka Long-Evans Tokushima Fatty rats, an obese insulin-resistant rat model, for 6 weeks (from 3 weeks before to 3 weeks after carotid artery injury). Immunohistochemical staining was performed to investigate cell proliferation and apoptosis in the injured arteries. Cell migration, caspase-3 activity and DNA fragmentation, monocyte adhesion, and ICAM-1/VCAM-1 levels were explored in vitro. Treatment with EGb761 dose-dependently reduced intima-media ratio, proliferation of vascular smooth muscle cells (VSMCs) and induced greater apoptosis than the controls. Proliferation and migration of VSMCs in vitro were also decreased by the treatment of EGb761. Glucose homeostasis and circulating adiponectin levels were improved, and plasma hsCRP concentrations were decreased in the treatment groups. Caspase-3 activity and DNA fragmentation increased while monocyte adhesion and ICAM-1/VCAM-1 levels decreased significantly. Among subcomponents of EGb761, kaemferol and quercetin reduced VSMC migration and increased caspase activity. CONCLUSIONS: EGb761 has a protective role in the development of atherosclerosis and is a potential therapeutic agent for preventing atherosclerosis

Effect of a Dipeptidyl Peptidase-IV Inhibitor, Des-Fluoro-Sitagliptin, on Neointimal Formation after Balloon Injury in Rats

Background: Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related mechanisms. Methods and Findings: Otsuka Long-Evans Tokushima Fatty rats were grouped into four: control (normal saline) and sitagliptin 100, 250 and 500 mg/kg per day (n = 10 per group). Sitagliptin or normal saline were given orally from 1 week before to 2 weeks after carotid injury. After 3 weeks of treatment, sitagliptin treatment caused a significant and dose-dependent reduction in intima-media ratio (IMR) in obese diabetic rats. This effect was accompanied by improved glucose homeostasis, decreased circulating levels of high-sensitivity C-reactive protein (hsCRP) and increased adiponectin level. Moreover, decreased IMR was correlated significantly with reduced hsCRP, tumor necrosis factor-$\alpha$ and monocyte chemoattractant protein-1 levels and plasminogen activator inhibitor-1 activity. In vitro evidence with vascular smooth muscle cells (VSMCs) demonstrated that proliferation and migration were decreased significantly after sitagliptin treatment. In addition, sitagliptin increased caspase-3 activity and decreased monocyte adhesion and NFκB activation in VSMCs. Conclusions: Sitagliptin has protective properties against restenosis after carotid injury and therapeutic implications for treating macrovascular complications of diabetes

The Function of Heterodimeric AP-1 Comprised of c-Jun and c-Fos in Activin Mediated Spemann Organizer Gene Expression

BACKGROUND:Activator protein-1 (AP-1) is a mediator of BMP or FGF signaling during Xenopus embryogenesis. However, specific role of AP-1 in activin signaling has not been elucidated during vertebrate development. METHODOLOGY/PRINCIPAL FINDINGS:We provide new evidence showing that overexpression of heterodimeric AP-1 comprised of c-jun and c-fos (AP-1(c-Jun/c-Fos)) induces the expression of BMP-antagonizing organizer genes (noggin, chordin and goosecoid) that were normally expressed by high dose of activin. AP-1(c-Jun/c-Fos) enhanced the promoter activities of organizer genes but reduced that of PV.1, a BMP4-response gene. A loss of function study clearly demonstrated that AP-1(c-Jun/c-Fos) is required for the activin-induced organizer and neural gene expression. Moreover, physical interaction of AP-1(c-Jun/c-Fos) and Smad3 cooperatively enhanced the transcriptional activity of goosecoid via direct binding on this promoter. Interestingly, Smad3 mutants at c-Jun binding site failed in regulation of organizer genes, indicating that these physical interactions are specifically necessary for the expression of organizer genes. CONCLUSIONS/SIGNIFICANCE:AP-1(c-Jun/c-Fos) plays a specific role in organizer gene expression in downstream of activin signal during early Xenopus embryogenesis

Pregled AC-DC i DC-DC pretvarača za primjene u LED rasvjeti

High-Brightness Light Emitting Diodes (HB-LEDs) are considered the future trend in lighting not only due to their high efficiency and high reliability, but also due to their other outstanding characteristics: chromatic variety, shock and vibration resistance, etc. Nevertheless, they need the development of new power supplies especially designed for boosting and taking advantage of their aforementioned characteristics. Besides, their behaviour is completely different from the rest of lighting devices and, consequently, it should be also taken into account in the design of the converters used to drive them. As a result, many well-known topologies have been optimized or redesigned in order to be used in LED–lighting applications and many new topologies have come up in the recent years with the same purpose. In this paper, the main HB-LED characteristics will be explained, highlighting how they influence the design of their power supplies. After, the main topologies will be presented from the simplest to the most complex ones, analysing their advantages and disadvantages.Svjetleće diode s visokom razinom svjetline (HB-LED) smatraju se budućim trendom u rasvjeti zahvaljujući ne samo visokom stupnju efikasnosti i pouzdanosti, nego i njihovim izvanrednim svojstvima: raznolikost boja, otpornost na udarce i vibracije i sl. Ipak, s ciljem potpunog iskorištenja prethodno spomenutih svojstava, potrebno je razviti nove, posebno osmišljene izvore napajanja. Osim toga, ponašanje im se posve razlikuje od ostalih tipova rasvjete što je potrebno uzeti u obzir pri projektiranju pretvarača za njihovo napajanje. Kao posljedica toga, mnoge su poznate topologije pretvarača optimirane ili preoblikovane posebno za primjenu u LED rasvjeti, a zadnjih nekoliko godina mnoge nove su se tek pojavile. U ovom članku objašnjena su osnovna HB-LED svojstva naglašavajući njihov utjecaj na razvoj izvora napajanja. Uz to, prikazane su osnovne topologije, od najjednostavnijih do najsloženijih, ujedno analizirajući prednosti i nedostatke pojedinih