N=2 SYM RG Scale as Modulus for WDVV Equations

We derive a new set of WDVV equations for N=2 SYM in which the renormalization scale $\Lambda$ is identified with the distinguished modulus which naturally arises in topological field theories.Comment: 6 pages, LaTe

Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection

Functional magnetic resonance imaging can demonstrate the functional anatomy of cognitive processes. In patients with refractory temporal lobe epilepsy, evaluation of preoperative verbal and visual memory function is important as anterior temporal lobe resections may result in material specific memory impairment, typically verbal memory decline following left and visual memory decline after right anterior temporal lobe resection. This study aimed to investigate reorganization of memory functions in temporal lobe epilepsy and to determine whether preoperative memory functional magnetic resonance imaging may predict memory changes following anterior temporal lobe resection. We studied 72 patients with unilateral medial temporal lobe epilepsy (41 left) and 20 healthy controls. A functional magnetic resonance imaging memory encoding paradigm for pictures, words and faces was used testing verbal and visual memory in a single scanning session on a 3T magnetic resonance imaging scanner. Fifty-four patients subsequently underwent left (29) or right (25) anterior temporal lobe resection. Verbal and design learning were assessed before and 4 months after surgery. Event-related functional magnetic resonance imaging analysis revealed that in left temporal lobe epilepsy, greater left hippocampal activation for word encoding correlated with better verbal memory. In right temporal lobe epilepsy, greater right hippocampal activation for face encoding correlated with better visual memory. In left temporal lobe epilepsy, greater left than right anterior hippocampal activation on word encoding correlated with greater verbal memory decline after left anterior temporal lobe resection, while greater left than right posterior hippocampal activation correlated with better postoperative verbal memory outcome. In right temporal lobe epilepsy, greater right than left anterior hippocampal functional magnetic resonance imaging activation on face encoding predicted greater visual memory decline after right anterior temporal lobe resection, while greater right than left posterior hippocampal activation correlated with better visual memory outcome. Stepwise linear regression identified asymmetry of activation for encoding words and faces in the ipsilateral anterior medial temporal lobe as strongest predictors for postoperative verbal and visual memory decline. Activation asymmetry, language lateralization and performance on preoperative neuropsychological tests predicted clinically significant verbal memory decline in all patients who underwent left anterior temporal lobe resection, but were less able to predict visual memory decline after right anterior temporal lobe resection. Preoperative memory functional magnetic resonance imaging was the strongest predictor of verbal and visual memory decline following anterior temporal lobe resection. Preoperatively, verbal and visual memory function utilized the damaged, ipsilateral hippocampus and also the contralateral hippocampus. Memory function in the ipsilateral posterior hippocampus may contribute to better preservation of memory after surgery

Multiple effects of CDK4/6 inhibition in cancer: From cell cycle arrest to immunomodulation

Dysregulation of the cell cycle is a hallmark of cancer that leads to aberrant cellular proliferation. CDK4/6 are cyclin-dependent kinases activated in response to proliferative signaling, which induce RB hyper-phosphorylation and hence activation of E2F transcription factors, thus promoting cell cycle progression through the S phase. Pharmacologic inhibition of CDK4/6 by palbociclib, ribociclib, or abemaciclib has been showing promising activity in multiple cancers with the best results achieved in combination with other agents. Indeed, CDK4/6 inhibitors are currently approved in combination with endocrine therapy for the treatment of estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. Moreover, a number of clinical trials are currently underway to test the efficacy of combining CDK4/6 inhibitors with different drugs not only in breast but also in other types of cancer. Beyond the inhibition of cell proliferation, CDK4/6 inhibitors have recently revealed new effects on cancer cells and on tumor microenvironment. In particular, it has been reported that these agents induce a senescent-like phenotype, impact on cell metabolism and exert both immunomodulatory and immunogenic effects. Here we describe recent data on the anti-tumor effects of CDK4/6 inhibitors as single agents or in combined therapies, focusing in particular on their metabolic and immunomodulatory activities

Nonperturbative Relations in N=2 SUSY Yang-Mills and WDVV equation

We find the nonperturbative relation between $\langle {\rm tr} \phi^2 \rangle$, $\langle {\rm tr} \phi^3\rangle$ the prepotential ${\cal F}$ and the vevs $\langle \phi_i\rangle$ in $N=2$ supersymmetric Yang-Mills theories with gauge group $SU(3)$. Nonlinear differential equations for ${\cal F}$ including the Witten -- Dijkgraaf -- Verlinde -- Verlinde equation are obtained. This indicates that $N=2$ SYM theories are essentially topological field theories and that should be seen as low-energy limit of some topological string theory. Furthermore, we construct relevant modular invariant quantities, derive canonical relations between the periods and investigate the structure of the beta function by giving its explicit form in the moduli coordinates. In doing this we discuss the uniformization problem for the quantum moduli space. The method we propose can be generalized to $N=2$ supersymmetric Yang-Mills theories with higher rank gauge groups.Comment: 12 pages, LaTex. Expanded version. New results, corrections, references and acknowledgements adde

Taming open/closed string duality with a Losev trick

A target space string field theory formulation for open and closed B-model is provided by giving a Batalin-Vilkovisky quantization of the holomorphic Chern-Simons theory with off-shell gravity background. The target space expression for the coefficients of the holomorphic anomaly equation for open strings are obtained. Furthermore, open/closed string duality is proved from a judicious integration over the open string fields. In particular, by restriction to the case of independence on continuous open moduli, the shift formulas of [7] are reproduced and shown therefore to encode the data of a closed string dual.Comment: 22 pages, no figures; v.2 Refs. and a comment added

Purification of recombinant hepatitis delta antigen expressed in E. coli cells

AbstractRecombinant DNA technology enables the massive production of recombinant hepatitis delta antigen (recHDAg) retaining immunological properties and transport functions. However, purification procedures of the recombinant delta antigen have, to date, not been described in the literature. We present a purification procedure allowing one to obtain highly purified recHDAg from bacterial cells expressing the hepatitis delta antigen

N=2 gauge theories on toric singularities, blow-up formulae and W-algebrae

We compute the Nekrasov partition function of gauge theories on the (resolved) toric singularities C2/\u393 in terms of blow-up formulae. We discuss the expansion of the partition function in the e1,e2 \u2192 0 limit along with its modular properties and how to derive them from the M-theory perspective. On the two-dimensional conformal field theory side, our results can be interpreted in terms of representations of the direct sum of Heisenberg plus W_N -algebrae with suitable central charges, which can be computed from the fan of the resolved toric variety. We provide a check of this correspondence by computing the central charge of the two-dimensional theory from the anomaly polynomial of M5-brane theory. Upon using the AGT correspondence our results provide a candidate for the conformal blocks and three-point functions of a class of the two-dimensional CFTs which includes parafermionic theories

The stringy instanton partition function

We perform an exact computation of the gauged linear sigma model associated to a D1-D5 brane system on a resolved A 1 singularity. This is accomplished via supersymmetric localization on the blown-up two-sphere. We show that in the blow-down limit the partition function reduces to the Nekrasov partition function evaluating the equivariant volume of the instanton moduli space. For finite radius we obtain a tower of world-sheet instanton corrections, that we identify with the equivariant Gromov-Witten invariants of the ADHM moduli space. We show that these corrections can be encoded in a deformation of the Seiberg-Witten prepotential. From the mathematical viewpoint, the D1-D5 system under study displays a twofold nature: the D1-branes viewpoint captures the equivariant quantum cohomology of the ADHM instanton moduli space in the Givental formalism, and the D5-branes viewpoint is related to higher rank equivariant Donaldson-Thomas invariants