Matrix String Theory, 2D SYM Instantons and affine Toda systems

Extending a recent result of S.B. Giddings, F. Hacquebord and H. Verlinde, we show that in the U(N) SYM Matrix theory there exist classical BPS instantons which interpolate between different closed string configurations via joining/splitting interactions similar to those of string field theory. We construct them starting from branched coverings of Riemann surfaces. For the class of them which we analyze in detail the construction can be made explicit in terms U(N) affine Toda field theories.Comment: 12 pages, 1 eps figure, JHEP.cls LaTeX2e class file; sign corrected, ref. and acknowledgements update

Heterotic Matrix String Theory and Riemann Surfaces

We extend the results found for Matrix String Theory to Heterotic Matrix String Theory, i.e. to a 2d O(N) SYM theory with chiral (anomaly free) matter and N=(8,0) supersymmetry. We write down the instanton equations for this theory and solve them explicitly. The solutions are characterized by branched coverings of the basis cylinder, i.e. by compact Riemann surfaces with punctures. We show that in the strong coupling limit the action becomes the heterotic string action plus a free Maxwell action. Moreover the amplitude based on a Riemann surface with p punctures and h handles is proportional to g^{2-2h-p}, as expected for the heterotic string interaction theory with string coupling g_s=1/g.Comment: 17 pages, JHEP LaTeX style, sentence delete

Counting Yang-Mills Instantons by Surface Operator Renormalization Group Flow

We show that the nonperturbative dynamics of N=2 super-Yang-Mills theories in a self-dual ω background and with arbitrary simple gauge group is fully determined by studying renormalization group equations of vacuum expectation values of surface operators generating one-form symmetries. The corresponding system of equations is a nonautonomous Toda chain, the time being the renormalization group scale. We obtain new recurrence relations which provide a systematic algorithm computing multi-instanton corrections from the tree-level one-loop prepotential as the asymptotic boundary condition of the renormalization group equations. We exemplify by computing the E6 and G2 cases up to two instantons

Extracellular vesicles in cardiac repair and regeneration: Beyond stem-cell-based approaches.

The adult human heart poorly regenerate after injury due to the low self-renewal capability retained by adult cardiomyocytes. In the last two decades, several clinical studies have reported the ability of stem cells to induce cardiac regeneration. However, low cell integration and survival into the tissue has limited stem-cell-based clinical approaches. More recently, the release of paracrine mediators including extracellular vesicles (EV) has been recognized as the most relevant mechanism driving benefits upon cell-based therapy. In particular, EV have emerged as key mediators of cardiac repair after damage, in terms of reduction of apoptosis, resolution of inflammation and new blood vessel formation. Herein, mechanisms involved in cardiac damage and regeneration, and current applications of EV and their small non-coding RNAs (miRNAs) in regenerative medicine are discussed

Combining environmental niche models, multi-grain analyses, and species traits identifies pervasive effects of land use on butterfly biodiversity across Italy.

Understanding how species respond to human activities is paramount to ecology and conservation science, one outstanding question being how large-scale patterns in land use affect biodiversity. To facilitate answering this question, we propose a novel analytical framework that combines environmental niche models, multi-grain analyses, and species traits. We illustrate the framework capitalizing on the most extensive dataset compiled to date for the butterflies of Italy (106,514 observations for 288 species), assessing how agriculture and urbanization have affected biodiversity of these taxa from landscape to regional scales (3-48 km grains) across the country while accounting for its steep climatic gradients. Multiple lines of evidence suggest pervasive and scale-dependent effects of land use on butterflies in Italy. While land use explained patterns in species richness primarily at grains ≤12 km, idiosyncratic responses in species highlighted "winners" and "losers" across human-dominated regions. Detrimental effects of agriculture and urbanization emerged from landscape (3-km grain) to regional (48-km grain) scales, disproportionally affecting small butterflies and butterflies with a short flight curve. Human activities have therefore reorganized the biogeography of Italian butterflies, filtering out species with poor dispersal capacity and narrow niche breadth not only from local assemblages, but also from regional species pools. These results suggest that global conservation efforts neglecting large-scale patterns in land use risk falling short of their goals, even for taxa typically assumed to persist in small natural areas (e.g., invertebrates). Our study also confirms that consideration of spatial scales will be crucial to implementing effective conservation actions in the Post-2020 Global Biodiversity Framework. In this context, applications of the proposed analytical framework have broad potential to identify which mechanisms underlie biodiversity change at different spatial scales

BPS Quivers of Five-Dimensional SCFTs, Topological Strings and q-Painlevé Equations

We study the discrete flows generated by the symmetry group of the BPS quivers for Calabi–Yau geometries describing five-dimensional superconformal quantum field theories on a circle. These flows naturally describe the BPS particle spectrum of such theories and at the same time generate bilinear equations of q-difference type which, in the rank one case, are q-Painlevé equations. The solutions of these equations are shown to be given by grand canonical topological string partition functions which we identify with τ-functions of the cluster algebra associated to the quiver. We exemplify our construction in the case corresponding to five-dimensional SU(2) pure super Yang–Mills and Nf= 2 on a circle

Matrix String Theory and its Moduli Space

The correspondence between Matrix String Theory in the strong coupling limit and IIA superstring theory can be shown by means of the instanton solutions of the former. We construct the general instanton solutions of Matrix String Theory which interpolate between given initial and final string configurations. Each instanton is characterized by a Riemann surface of genus h with n punctures, which is realized as a plane curve. We study the moduli space of such plane curves and find out that, at finite N, it is a discretized version of the moduli space of Riemann surfaces: instead of 3h-3+n its complex dimensions are 2h-3+n, the remaining h dimensions being discrete. It turns out that as $N$ tends to infinity, these discrete dimensions become continuous, and one recovers the full moduli space of string interaction theory.Comment: 30 pages, LaTeX, JHEP.cls class file, minor correction

Bronchoalveolar lavage fluid cytological findings in healthy Amiata donkeys

Background: The approach to respiratory diseases in donkeys is similar to that for horses; nevertheless, Bronchoalveolar lavage fluid (BALF) and tracheal wash cytology in this species have been described only a few times in the literature. Aim: To describe BALF cytological findings in a cohort of 24 healthy Amiata donkeys. Methods: Bronchoalveolar lavage (BAL) was carried out via standing sedation with a large animal where the BAL catheter passed blindly through the nasal passage into the trachea. Results: The total nucleated cell count of the BALF was found similar to that already described in healthy horses and donkeys. No differences in the differential count were observed according to age and sex. A decreased macrophage percentage and an increased eosinophil percentage were observed in our donkey population when compared to the existing reference range for horses. Conclusion: The reference intervals for BAL cytology in donkeys may be significantly different for those referred for horses