Asymptotic safety with Majorana fermions and new large N equivalences

Using Majorana fermions and elementary mesons we find new massless quantum field theories with weakly interacting ultraviolet fixed points. We also find new classes of large N equivalences among SU, SO, and Sp gauge theories with different types of matter fields and Yukawa interactions. Results include a triality of asymptotically safe theories and dualities between asymptotically free matter-gauge theories with identical fixed points, phase diagrams, and scaling exponents. Implications for conformal field theory and orbifold reductions are indicated

FAA Perspective

This viewgraph presentation describes the Federal Aviation Administration's perspective on improvements on aircraft icing. The most important areas that are discussed include: 1) Improvements in SLD engineering tools to meet concerns about means of compliance (MOC); and 2) 3-D iced aerodynamics

Proceedings of the 38th Annual Meeting, Southern Soybean Disease Workers (March 9-10, 2011, Pensacola Beach, Florida)

Contents Southern United States Soybean Disease Loss Estimates for 2010. Compiled by SR Koenning Poster presentation Soybean Varieties and Breeding Lines Shown With Resistance to Reniform Nematode in Greenhouse Tests, 1998-2010 R. T. Robbins, and L. E. Jackson Oral presentations Frogeye Leaf Spot (Cercorosa sojina) symposium (Boyd Padgett, moderator) Development of Baseline Cercospora sojina Sensitivity Levels to Quinone Outside Inhibitor Fungicides and Monitoring for Resistance. GR Zhang and CA Bradley Soybean Pathogen Found to be Resistant to Fungicides MA Newman and CA Bradley Strobilurin-resistant Cercospora sojina in Kentucky: Field History. D Hershman Graduate student paper competition (Tom Allen, moderator) Mycoparasitism of Phakopsora pachyrhizi by Simplicillium lanosoniveum and Its Effects on Soybean Rust: A Microscopy Study. NA Ward, K Maruthachalam, KV Subbarao, M Brown, Y Xiao, CL Robertson, CG Giles, and RW Schneider Relationship Between Stink Bugs and Phomopsis Seed Decay in Mississippi Soybean Production. JL Jones, A Catchot, and F Musser Survey of Multiple Seed Isolates of Cercospora kikuchii from Louisiana, Arkansas, and Missouri for Resistance to Thiophanate-methyl, Azoxystrobin, and Pyraclostrobin in vitro. PP Price, MA Purvis, GB Padgett, and RW Schneider Assessing the Validity of Diagnostic Quantitative PCR Assays for Phakopsora pachyrhizi and P. meibomiae. TA Rush, RW Schneider, MC Aime, and GL Hartman Southern Soybean Disease Workers paper session (Jason Bond and Tom Allen, moderators) Review of the 2010 Sudden Death Syndrome Outbreak in Iowa. L Leandro Managing Frogeye Leaf Spot in Illinois. C Vick, A Vick, B Hoene, M Butera, H Sabo, A Ward, and JP Bond The Fusarium Root Rot Complex on Soybean in Minnesota. D Malvick The Influence of Fungicide Seed Treatments on Plant Establishment and Grain Quality and Yield. GB Padgett, M Purvis, and P Price, III Yield Loss Relationships for Several Soybean Diseases and Development of a Cost:Benefit Calculator. RW Schneider, GB Padgett, KM Guidry, and PK Bollich NCSRP Update. D Wright Monitoring for Soybean Rust at Guantanamo Bay. EJ Sikora Fungicide Efficacy Against the 2010 Aerial Blight Epidemic in Louisiana. CA Hollier Foliar Fungicides Impact on Arkansas’ Endemic Soybean Diseases. CM Coker and AM Greer USB Funding update. R Joost Pythium spp., Phytophthora sojae, Macrophomina, and SCN: Just a Few Challenges While Waiting for Soybean Rust in Ohio. A Dorrance, M Ellis, and K Gearhart Fluxapyroxad: New Fungicide for Soybean Disease Control. G Fellows and N Fassler Maturity Group IV Soybean Seed Quality: Mississippi Perspectives from 2009 and 2010. TW Allen, CH Koger, A Catchot, D Cook, J Gore, N Buehring, HR Smith, and F Musser S05-11482: a high yielding soybean with resistance to multiple diseases and nematode species. JG Shannon, JA Wrather, MA Woolard, SL Smothers, SM Pathan, HT Nguyen, and RT Robbins Proceedings of the Southern Soybean Disease Workers are published annually by the Southern Soybean Disease Workers. Text, references, figures, and tables are reproduced as they were submitted by authors. The opinions expressed by the participants at this conference are their own and do not necessarily represent those of the Southern Soybean Workers. Mention of a trademark or proprietary products in this publication does not constitute a guarantee, warranty, or endorsement of that product by the Southern Soybean Disease Workers

Extracellular matrix stiffness controls cardiac fibroblast proliferation via the nuclear factor-Y (NF-Y) transcription factor

The proliferative expansion of cardiac fibroblasts (CF) contributes towards cardiac fibrosis, which results in myocardial stiffening, cardiac dysfunction, and heart failure. CF sense and respond to increased stiffness of their local extracellular matrix, modulating their phenotype towards increased collagen synthesis and higher proliferation, leading potentially to a vicious circle of positive feedback. Here we describe a novel mechanism that mediates increased CF proliferation in response to a pathologically stiff Exteracellular matrix (ECM). The mechanism we describe is independent of the well-characterised mechano-sensitive transcript factors, YAP-TEAD and MKL1-SRF, which our data indicate are only responsible for part of the genes induced by stiffened ECM. Instead, our data identify Nuclear Factor-Y (NF-Y) as a novel mechanosensitive transcription factor, which mediates enhanced CF proliferation in response to a stiff ECM. We show that levels of NF-YA protein, the major regulatory subunit of NF-Y, and NF-Y transcriptional activity, are increased by a stiff ECM. Indeed, NF-Y activity drives the expression of multiple cell-cycle genes. Furthermore, NF-YA protein levels are dependent on FAK signalling suggesting a mechanistic link to ECM composition. Consistent with its role as a mechano-sensor, inhibition of NF-Y using siRNA or dominant negative mutant blocks CF proliferation on plastic in vitro, which models a stiff ECM, whereas ectopic expression of NF-YA increases the proliferation of cells interacting under conditions that model a physiologically soft ECM. In summary, our data demonstrate that NF-Y is a biomechanically sensitive transcription factor that promotes CF proliferation in a model of pathologically stiffened ECM

Pancreatic transplantation at the University of Pittsburgh.

Campath-1H preconditioning with tacrolimus monotherapy is an effective immunosuppressive regimen for pancreas transplantation, with acceptable patient and graft survival rates early after transplantation. Rejection rates are low under this protocol if the tacrolimus level is kept consistently >10 ng/ml. This immunosuppressive protocol, combined with recent technical refinements, has resulted in lower rates of thrombosis and overall complications. Pancreatic transplantation en-bloc with visceral grafts has the following unique features: Diabetes is a rare indication, and HLA matching is not required. The gland is immunologically protected by the simultaneously transplanted visceral organs. Disease gravity, surgical complexity and gut alloimmunity influence the overall pancreatic allograft survival. The current UNOS listing criteria and data registry should be modified for obvious logistic and scientific reasons

Splink: Latest developments and applications

Funded by ADR UK, a new data linking team at the Ministry of Justice set out to link administrative datasets across the justice space, for internal use and sharing with external researchers. To achieve this aim we sought a linkage implementation that was probabilistic, flexible, scalable and ideally open source. Taking into account the tools available at the MoJ, existing open-source software (and paid alternatives) failed to meet our desired criteria. It was decided to develop a software package that builds on FastLink’s implementation in R of an Expectation-Maximisation algorithm to estimate a Fellegi-Sunter linkage model, adding a range of technical improvements, increased functionality and customisation options. Distributed computing offered by Spark could facilitate comparable linkage jobs that run on much larger datasets and much faster. Working with government data, accountability and transparency are vital, so the data and models are made accessible by a range of intuitive visualizations. The Splink python package has been downloaded over 6 million times. This initially used Spark to deliver its superior performance, but Splink v3 caters for various SQL backends and more potential users. As we have made Splink more intuitive, more accessible, and more extensively documented we continue to receive feedback and contributions from around the world, driving further continuous development. Through technical innovation and user-focused development, Splink has improved access to cutting-edge data linkage, and created groundbreaking research opportunities at MoJ and beyond. The team is grateful to ONS and other collaborators for testing and adopting these tools, and we will present some of the latest developments as well as examples of how Splink has been used worldwide

The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations

Abstract Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however, the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-directional MR on ADHD liability and six obesity-related traits using summary statistics from the largest available meta-analyses of genome-wide association studies. We also examined the shared genetic aetiology between ADHD symptoms (inattention and hyperactivity) and body mass index (BMI) by PRS association analysis using longitudinal data from Northern Finland Birth Cohort 1986 (NFBC1986, n = 2984). Lastly, we examined the impact of the prenatal environment by association analysis of maternal pre-pregnancy BMI and offspring ADHD symptoms, adjusted for PRS of both traits, in NFBC1986 dataset. Through MR analyses, we found evidence for bidirectional causality between ADHD liability and obesity-related traits. PRS association analyses showed evidence for genetic overlap between ADHD symptoms and BMI. We found no evidence for a difference between inattention and hyperactivity symptoms, suggesting that neither symptom subtype is driving the association. We found evidence for association between maternal pre-pregnancy BMI and offspring ADHD symptoms after adjusting for both BMI and ADHD PRS (association p-value = 0.027 for inattention, p = 0.008 for hyperactivity). These results are consistent with the hypothesis that the co-occurrence between ADHD and obesity has both genetic and prenatal environmental origins

Phylogenomic assessment prompts recognition of the Serianthes clade and confirms the monophyly of Serianthes and its relationship with Falcataria and Wallaceodendron in the wider ingoid clade (Leguminosae, Caesalpinioideae)

The Indo-Pacific legume genus Serianthes was recently placed in the Archidendron clade (sensu Koenen et al. 2020), a subclade of the mimosoid clade in subfamily Caesalpinioideae, which also includes Acacia, Archidendron, Archidendropsis, Falcataria, Pararchidendron, Paraserianthes and Wallaceodendron. Serianthes comprises ca. 18 species, five subspecies and two varieties that are characterised by bipinnately compound leaves with alternate sessile leaflets, branched axillary corymbiform panicles and woody indehiscent pods. Generic relationships, as well as species relationships within genera in the Archidendron clade, remain uncertain. While the sister relationship between Serianthes and the genus Falcataria is strongly supported by molecular data, the distinction between Serianthes and the monotypic genus Wallaceodendron has been questioned, based on their similar flower and fruit morphologies. We combined three gene-enriched hybrid capture DNA sequence datasets (generated from the 964 mimobaits v1 probe set, the expanded 997 mimobaits v2 probe set and the GoFlag angiosperm 408 probe set) and used their overlapping markers (77 loci of the target exonic and flanking regions) to test the monophyly of Serianthes and to investigate generic relationships within the Archidendron clade using 55 ingoid plus two outgroup taxa. We show that Serianthes is monophyletic, confirm the Serianthes + Falcataria sister relationship to Wallaceodendron and recognise this combined clade as the Serianthes clade within the Archidendron clade. We also evaluated the use of overlapping loci across datasets in combination with concordance analyses to test generic relationships and further investigate previously unresolved relationships across the wider ingoid clade. Concordance analysis revealed limited gene tree conflicts near the tips of the Archidendron clade, but increased discordance at the base of the clade, which could be attributed to rapid lineage divergence (radiation) and/or incomplete lineage sorting

Cosmological Hydrodynamics with Multi-Species Chemistry and Nonequilibrium Ionization and Cooling

We have developed a method of solving for multi-species chemical reaction flows in non--equilibrium and self--consistently with the hydrodynamic equations in an expanding FLRW universe. The method is based on a backward differencing scheme for the required stability when solving stiff sets of equations and is designed to be efficient for three-dimensional calculations without sacrificing accuracy. In all, 28 kinetic reactions are solved including both collisional and radiative processes for the following nine separate species: H, H+, He, He+, He++, H-, H2+, H2, and e-. The method identifies those reactions (involving H- and H2+) ocurring on the shortest time scales, decoupling them from the rest of the network and imposing equilibrium concentrations to good accuracy over typical cosmological dynamical times. Several tests of our code are presented, including radiative shock waves, cosmological sheets, conservation constraints, and fully three-dimensional simulations of CDM cosmological evolutions in which we compare our method to results obtained when the packaged routine LSODAR is substituted for our algorithms.Comment: Latex and postscript, 24 pages, with 6 figures. The paper is also available at http://zeus.ncsa.uiuc.edu:8080/~abel/PGas/bib.html Submitted to New Astronom

Associations of changes in physical activity and sedentary time with weight recurrence after bariatric surgery: a 5-year prospective study

Background Increasing physical activity and limiting sedentary time may minimize weight recurrence after bariatric surgery. However, few studies have evaluated potential associations of objectively-measured physical activity and sedentary time with post-surgical weight recurrence over time. Aims To evaluate associations of change in physical activity and sedentary time with weight recurrence after bariatric surgery. Methods Participants from the Oslo Bariatric Surgery Study, a prospective cohort study, wore an ActiGraph monitor for seven days at 1- and 5 years after surgery to assess daily physical activity and sedentary time. Participants’ weight was measured at in-person clinic visits. Chi-square Test and Paired-samples T-test evaluated group differences and change over time, while Pearson’s Correlation, multiple logistic and linear regression investigated associations between variables. Results Five years after surgery 79 participants (70.5% response rate, 81% female) (mean (sd) age: 54.0 (±9.3), BMI: 32.1 (±4.7)) had valid monitor data. Participants increased their sedentary time (71.4 minutes/day (95% CI: 54.2–88.6, p = <0.001)) and reduced daily steps (−1411.1 (95% CI: 737.8–208.4), p = <0.001), light physical activity (−54.1 min/day (95% CI: 40.9–67.2, p = <0.001)), and total physical activity (−48.2 (95% CI: 34.6–63.3), p = <0.001) from 1- to 5 years after surgery. No change was found for moderate-to-vigorous intensity physical activity. No associations were found between changes in steps, physical activity or sedentary time and weight recurrence. Conclusion Participants increased sedentary time and decreased light- and total physical activity between 1- and 5 years post-surgery. Overall, changes in physical activity and sedentary time were not associated with weight recurrence. Interventions to help patients increase physical activity and limit sedentary time after bariatric surgery are needed.publishedVersio