CULTURAL HERITAGE DISSEMINATION: BIM MODELLING AND AR APPLICATION FOR A DIACHRONIC TALE

The research purpose is to present a project of cultural dissemination and enhancement of the “Madonna della Pace” Sanctuary at Rocchetta di Airuno (Lecco - Italy), based on an immersive experience of knowledge of the history and places that characterize not only the sanctuary but also the “Cammino di Sant’Agostino” (of which it is one of the stages). The research goal focuses on the direct employment and exploitation of HBIM models for the digital fruition project. An integrated digital survey based on a terrestrial laser scanner and photogrammetry was conducted to provide a complete geometrical representation of the sanctuary and its surroundings. Both output point clouds were employed as metric and geometric references to create the reality-based parametric model. Specifically, the work focuses on creating a three-dimensional chronological model of the sanctuary, which not only represents the current state of the cultural asset but is also enriched through the definition of different evolutionary phases of the architectural artifact based on an indepth study of the photographic and bibliographic documentations. Four Project Phasing has been identified to represent the most significant transformations of the building and were managed using the time parameter in the same BIM project. The sanctuary geometric and parametric models were displayed and navigable thanks to the aid of Virtual and Augmented Reality applications. A VR environment was defined to display in the first person the textured model. Finally, an AR smartphone app prototype was developed to show tourists the sanctuary’s historical transformation over time

Point cloud management for a holographic visualization

This document aims to describe and verify the workflow from a digital survey of a building of historical value to its set up in an innovative holographic view. Via Lulli is a low-cost building of the beginning of the century organized in a closed-block part of a complex with rather small courtyards; the research topic concerns the verification of the process from acquisition with digital survey to convert the survey dataset into a hologram, considering the huge potential of this display system. Comparison among different point clouds, with different accuracy and dimension are related to the final navigation when transformed in holograms; several tests have been carried out to compare cloud density with the ability to see holograms in details with different zooms in to display small details, and zooms out in real time to view the entire model. First possibility to extend workflow with unity support and other plug-ins are supposed

Holographic visions for architecture in a park.

The Monza Park, with its more than 7 square meters of green area, divided between lawn and woods, its 110,000 tall trees, its 13 farmhouses, 3 historic villas, 13 m of fences and 90,000 visitors on spring Sundays, represents an irreplaceable source of wellness and sustainability for those who live near it. The pandemic situation of the 20s and 21s by reducing the movements and the possibility of coexistence of a large public in an open space has suggested the possibility of new forms of use and interaction of the same, even remotely, reproducing accurate Virtual Reality experiences. With this paper, the authors intend to illustrate a workflow from Scan to VR applications, taking advantage of the opportunity to explore digital acquisitions and additional materials available and functional to convey the values of open space and historical monuments immersed in them. The VR experiences have been structured for the navigation from the scale of architectural detail to the environmental one, with the goal of using the accurate model results for two different and remote instrumentations: a 7m diameter 360° theatre and a Holographic table, Euclideon Hologram Table©. Both situations, as opposed to hardware tools such as headset, favour the fruition for small groups of users

DNA damage induced by 7,12-dimethylbenz[a]anthracene in the liver and the mammary gland of rats exposed to polycyclic aromatic hydrocarbon enzyme inducers during perinatal life

The long-lasting modulating effect induced by the prenatal or neonatal exposure to phenobarbital (PB) and aroclor on the genotoxic activity of 7,12-dimethylbenz[a]anthracene (DMBA) in female Sprague-Dawley rats was studied. The effect was measured as DNA damage evaluated in the liver and in the mammary gland of 55-day-old animals, 4 and 24 h after an i.g. injection of 80 mg/kg of DMBA. PB was given per os, i.g. or in drinking water to pregnant females and by i.g. only to neonates or in adult progeny. Aroclor was injected i.g. in prenatal and in neonatal life, and a second dose was given in adult life. Under these experimental conditions it was shown that DNA damage kinetics caused by DMBA are modulated by exposure to PB and, to a minor extent, by aroclor. The amount and persistence of DNA damage were highest when PB was administered to neonates. An average 2-fold increase in the elution constants (K) of DNA in the liver and the mammary gland was observed 4 h after DMBA treatment, as compared to uninduced animals. Repeated enzyme induction by PB seems to reduce DMBA genotoxicity, as shown by a decrease in DNA damage and persistence in the liver and mammary gland. The inducibility of the monooxygenase enzyme system in perinatal life favouring metabolic activation of inactivation of polycyclic aromatic hydrocarbons might be critical in determining individual susceptibility of adult progeny to chemical carcinogenesis by DMB

On the Possibility of a Trans-Planckian Duality

We investigate the possibility of a trans-Planckian duality, which exchanges a manifold of events (space-time), with a manifold of momenta (energy-momentum). Gravity has a dual counter-part, that is, a geometric theory defined on the manifold of momenta. We provide a mathematical framework that can possibly realize this idea, and analyze its classical behaviour.Comment: 21 pages, 4 figure

Enhanced Interaction Experience for Holographic Visualization

Nowadays, holographic visualization pushes further the limits in exploring tri-dimensional digital con-tent. 3D models typically displayed through a computer screen now enter the real world as holograms. The Hologram Table allows users to visualize and manipulate huge 3D models as if they were in the space in front of them. Its use has already proved helpful for the virtual fruition and presentation of complex cultural heritage buildings and their design interventions, but it surely can do more. The work aims at exploring the possibility of expanding the capabilities of the Hologram Table interaction by developing a custom-designed experience to interact with 3D point cloud data coming from survey activity. The test case was the interesting building of the Santa Maria delle Grazie (Milan, Italy) basilica. Initial results are encouraging and show that the point model can be enriched with associated information and additional content (images and texts) available for holographic visualization

Structure and Computation in Immunoreagent Design : From Diagnostics to Vaccines

Novel immunological tools for efficient diagnosis and treatment of emerging infections are urgently required. Advances in the diagnostic and vaccine development fields are continuously progressing, with reverse vaccinology and structural vaccinology (SV) methods for antigen identification and structure-based antigen (re)design playing increasingly relevant roles. SV, in particular, is predicted to be the front-runner in the future development of diagnostics and vaccines targeting challenging diseases such as AIDS and cancer. We review state-of-the-art methodologies for structure-based epitope identification and antigen design, with specific applicative examples. We highlight the implications of such methods for the engineering of biomolecules with improved immunological properties, potential diagnostic and/or therapeutic uses, and discuss the perspectives of structure-based rational design for the production of advanced immunoreagents. Immunodiagnostic-based serological tests offer rapid and high-throughput diagnosis of multiple pathogens and can ascertain disease progression.3D structures of protein antigens can be used to predict epitope location using computational biology methods.Computationally designed synthetic epitopes can provide new chemical tools with distinct applications, from diagnosis and patient profiling to therapeutic approaches based on new vaccines.Structure-based antigen design is predicted to deliver future vaccines targeting challenging diseases such as HIV and cancer.As an alternative to nanoparticle epitope presentation systems, structure-based in silico epitope grafting and design methods may be adopted to transplant epitopes onto protein scaffolds to generate antigens that stimulate more potent immune responses

Digital Transformation in the Construction Sector: From BIM to Digital Twin

In the next years, perhaps more than ever before, a technological revolution will transform the construction sector in all its aspects, greatly affecting services, production, and supplies. With BIM, and even more considering the Digital Twin topic, the innovation of tools has entailed a methodological innovation for the whole sector, owing to virtual reality simulations and actual dynamic real-time monitoring. This research, starting from an integrated analysis between the current research trends and some relevant national and European projects about the digitalization of construction sector, aims at providing a systematic analysis of some of the pillars that are guiding this phenomenon. In detail, the state of the art, activities, and trends of standardization and platform development in construction sector are considered and intersected to provide a clear background towards the future trends in the sector

Compositional Performance Modelling with the TIPPtool

Stochastic process algebras have been proposed as compositional specification formalisms for performance models. In this paper, we describe a tool which aims at realising all beneficial aspects of compositional performance modelling, the TIPPtool. It incorporates methods for compositional specification as well as solution, based on state-of-the-art techniques, and wrapped in a user-friendly graphical front end. Apart from highlighting the general benefits of the tool, we also discuss some lessons learned during development and application of the TIPPtool. A non-trivial model of a real life communication system serves as a case study to illustrate benefits and limitations