Принципы семейной медицины и их практическое применение в Республике Молдова

Department of Family Medicine, Nicolae Testemitanu State Medical and Pharmaceutical University, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaFamily medicine is the medical specialty which provides continuous health care, encompassing for individual and family. Although the principles are the same, family medicine, family doctor skills depend on the location of the medical cabinet, the prevalence of disease in the territory, the resources available and the proximity to other medical centers and hospitals differ on the preparation of physicians worldwide. This study included 100 primary consultations to primary care provider, of which 50 consultations into a CMF type, and 50 in the CMF model. The results obtained have demonstrated significant differences in some bins in terms of the degree of compliance and application of the principles in the daily practice of the specialty.Семейная медицина — медицинская специальность, которая обеспечивает постоянное медицинское обслуживание, всеобъемлющее для индивидума и семьи. Хотя принципы семейной медицины являются те же, необходимые навыки семейного врача, зависят от местоположения медицинского кабинета, распространенности заболевания на территории, имеющихся ресурсов и близости к другим медицинским центрам и больницам, также различаются по подготовке врачей во всем мире. Это исследование включает 100 первичных консультаций у семейного врача, из которых 50 консультаций в типичном Центре Семейных Врачей и 50 в образцовом Центре Семейных Врачей. Полученные результаты продемонстрировали существенные различия в некоторых ячейках с точки зрения степени соблюдения и применения принципов в повседневной практике по специальности

Influence of ESP collector configuration on reduction of particulate emissions from biomass combustion facility

Development of compact electrostatic precipitators (ESPs) for reduction of particulate emissions from small scale biomass combustion is an actual task. Particle mass collection efficiency of an ESP depends from combustion conditions, geometry of precipitator ionizer, collector stage configuration and ESP operation parameters. The investigation of the influence of collector stage configuration on particle mass collection efficiency of a pilot space charge ESP was in the focus of the study. It was shown that the use of tube collector with integrated grounded plates enhanced particle mass collection efficiency. The loading of plates with aerosol provoked particle re-entrainment and decreased long-term ESP mass collection efficiency. The use of grounded brush electrodes ensured effective reduction of particle emissions but resulted in increase of pressure drop in the precipitator. The optimization of cleaning intervals of the ionizer and collector stages increased particle mass collection efficiency. It was shown, that the integration of automatic systems for ionizer and collector cleaning into the space charge ESP enhanced precipitator long-term operation stability and ensured effective reduction of particulate emissions form small scale biomass combustion

Heat and mass transfer in the process of electrofractionation of secondary milk products

Paper presented at the 6th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 30 June - 2 July, 2008.Complete and wasteless processing of milk envisages a complex utilization and recovery of raw products, including secondary resources, taking into account ecological factors due to high indices of biological and chemical oxygen demand of whey. Electrical activation of whey is one of the promising methods of processing of secondary milk raw products that we have studied and used for recovery of protein-mineral concentrate, inversion of lactose into lactulose and their subsequent application. The working regimes of heat and mass transfer, characteristics of the obtained products and advantages of electrophysical treatment are described.vk201

Study of electrohydrodynamic phenomena in high temperature high pressure nitrogen

The study of corona discharge current-voltage characteristics (CVCs) in high temperature high pressure (HTHP) gases is an important step in development of compact HTHP electrostatic equipment. The scope of the current work was the study of corona discharge CVCs in HTHP nitrogen. Corona discharge ionizer was installed inside of a HTHP casing. Ionizer included star-shaped high voltage electrodes installed inside of a grounded tube electrode. The grounded electrode could be heated. Tests were carried out at various gas pressure and grounded electrode temperatures. The CVC-direct and CVC-indirect characteristics were measured for positive and negative polarity of applied voltage. For the same values of applied voltage, current for negative corona was higher than for positive one. The increase of gas pressure stabilized corona discharge and increased corona onset voltage. Operation of the ionizer at CVC-indirect ensured stable corona discharge. Corona discharge CVCs have shown hysteresis loop which area depended on gas pressure and temperature

Caracteristica imunităţii humorale şi microbiocenoza intestinală la bolnavii cu tuberculoză pulmonară

A fost apreciat statutul imun humoral la 44 de pacienţi cu tuberculoză pulmonară, care au fost repartizaţi în 3 grupe: disbioză de gradu 1 – 13 bolnavi; gradul 2 -11 bolnavi şi gradul 3 -20 bolnavi. La toţi pacienţii a fost studiat subclasele de imunoglobuline A, M, G, nivelul complexelor imune circulante, concentraţia ALAT şi ASAT, indexul intoxicaţiei Kalf-Kalif şi indexul leucocitar al reactivităţii imune. S-a demonstrat că în dependenţă de gradul disfuncţiei microbiocenozei intestinale se agravează indicii statutului imun umoral, fermenţii ALAT şi ASAT. La bolnavii cu disfuncţie intestinală de gradul 3 s-a depistat cele mai vădite dereglări ale statutului imun şi funcţiei de detoxicare ale fi catului

TIN-X:target importance and novelty explorer

Abstract Motivation The increasing amount of peer-reviewed manuscripts requires the development of specific mining tools to facilitate the visual exploration of evidence linking diseases and proteins. Results We developed TIN-X, the Target Importance and Novelty eXplorer, to visualize the association between proteins and diseases, based on text mining data processed from scientific literature. In the current implementation, TIN-X supports exploration of data for G-protein coupled receptors, kinases, ion channels, and nuclear receptors. TIN-X supports browsing and navigating across proteins and diseases based on ontology classes, and displays a scatter plot with two proposed new bibliometric statistics: Importance and Novelty. Availability and Implementation http://www.newdrugtargets.org </jats:sec

Эпидемиологические и вирусологические аспекты гриппа, острых респираторных вирусных инфекций и тяжелых острых респираторных инфекций в Республике Молдова, сезон 2018/2019

Agenția Națională pentru Sănătate Publică, Congresul al VIII-lea al specialiștilor din domeniul sănătății publice și managementului sanitar 24-25 octombrie 2019 Chișinău, Republica MoldovaSezonul de gripă 2018/2019 a debutat mai devreme în comparație cu sezoanele precedente. Perioada epidemică a debutat în săptămâna 03/2019, atingând apogeul în săptămâna 06/2019 și s-a terminat în săptămâna 11/2019. Virusul gripal A(H1)pdm09 a fost predominant, fi ind detectat în 79,8% din cazurile de gripă confi rmate de laborator. Virusul gripal A(H3) a fost detectat în 20,2% cazuri. Virusurile gripale de tip B nu au fost detectate în acest sezon. Toate (4) virusurile gripale A(H1)pdm09 caracterizate genetic aparțin subgrupei 6B.1 (reprezentată prin A/Michigan/45/2015). Principalele caracteristici ale virusurilor din grupa 6B.1 sunt prezența substituțiilor aminoacizilor S84N, S162N (cu apariția unui nou loc potențial de glicozilare) și I216T în HA1. Virusurile gripale A/H3 detectate aparțin subclaselor 3C.2a1b și 3C.2a2. În ceea ce privește virusurile H3N2 circulante în prezent, caracterizarea lor antigenică prin reacția de hemaglutinoinhibare rămâne dificilă din cauza aglutinării instabile a globulelor roșii de cobai, curcan și umane. Nivelul morbidității prin gripă a sporit de 2,2 ori față de sezonul 2017/2018. Nivelul morbidității prin IACRS în sezonul 2018/2019 s-a majorat de 1,07 ori, iar prin SARI – de 1,17 ori față de sezonul precedent. Începând cu săptămâna 40/2018, virusurile respiratorii negripale au fost detectate în 37,7% (130/345) din probe colectate în timpul monitoringului în sistemul de tip santinelă. Au predominat rinovirusurile, adenovirusurile și virusul respirator sincițial.The influenza season started earlier that previous seasons. The epidemic period started at week 03/2019, peaked in week 06/2019 and ended in week 11/2019. Influenza A(H1)pdm09 was the predominant virus detected in 79,8% of ILI cases. Influenza A(H3) was detected in 20,2%. Influenza B viruses were not detected this season. All (4) of the A(H1)pdm09 viruses genetically characterized, belonged to the subgroup 6B.1 (represented by A/Michigan/45/2015). The main characteristics of viruses in the 6B.1 group are that the viruses carry the amino acid substitutions S84N, S162N (introducing a new potential glycosylation site) and I216T in HA1. Detected influenza A/ H3 viruses belonged to subclades 3C.2a1b and 3C.2a2. In the case of currently circulating H3N2 virus’s antigenic characterization continues to be difficult by HI assay due to variable agglutination of red blood cells from guinea pig, turkey and humans. The level of influenza morbidity increased 2,2 times compared to 2017/2018 season. The level of ARI morbidity in this season increased 1,07 times and the SARI recorded increased 1,17 times compared to the previous season. Since week 40/2018 other respiratory viruses were detected in 37,7% (130/345) of samples in sentinel surveillance. Rhinovirus, adenovirus and respiratory syncytial virus was detected in higher level during this season.Сезон гриппа 2018/2019 начался раньше, чем в предыдущие сезоны. Эпидемический период начался на неделе 03/2019, достигнув максимума на неделе 06/2019, и завершился на неделе 11/2019. Вирус гриппа A(H1)pdm09 был доминирующим и выявлен в 79,8% случаев гриппа. Вирус гриппа A(H3) был обнаружен в 20,2% случаев. Вирусы гриппа B не были выявлены в этом сезоне. Все (4) вирусы гриппа A(H1)pdm09б охарактеризованные генетически, относятся к подгруппе 6B.1 (представленную вирусом A/Michigan/45/2015). Основные характеристики вирусов из подгруппы 6B.1 – это наличие аминокислотных замен S84N, S162N (с появлением нового потенциального места гликозилирования) и I216T в HA1. Выявленные вирусы гриппа A/H3 относятся к подклассам 3C.2a1b и 3C.2a2. В случае циркулирующих в настоящее время H3N2, их антигенная характеристика с помощью реакции торможения гемаглютинации по-прежнему затруднена из за нестабильной агглютинации эритроцитов морской свинки, индейки и человека. Уровень заболеваемости гриппом повысился в 2,2 раза по сравнению с сезоном 2017/2018. Заболеваемость ОРВИ в сезоне 2018/2019 увеличилась в 1,07 раз по сравнению с предыдущим сезоном, а количество случаев ТОРИ увеличилось в 1,17 раз. Начиная с недели 40/2018 другие респираторные вирусы были выявлены в 37,7% (130/345) образцов, собранных во время дозорного надзора. Риновирусы, аденовирусы и респираторно-синцитиальные вирусы выявлялись в большом количестве в течении этого сезона