138 research outputs found
Differenzielle Wirksamkeit einer unterstützenden Gruppenintervention versus einer kognitiven Verhaltenstherapie (Cue-Exposure) bei verschiedenen Persönlichkeitsausprägungen alkoholabhängiger Männer
dl-canaline and 5-fluoromethylornithine. Comparison of two inactivators of ornithine aminotransferase
Разработка подсистемы администрирования для системы управления активами предприятия
В компании "Rubius" разрабатывается система управления активами (Enterprise Asset Management) "Rubius DrEAM". В данной системе отсутствует подсистема администрирования, вследствие чего администрирование выполняется вручную с излишними затратами труда времени и денег.
Целью выпускной квалификационной работы является разработка подсистемы администрирования, позволяющая настраивать конфигурацию и метаданные, необходимые для функционирования данной системой управления активами.
В выпускной квалификационной работе рассматриваются теоретические основы вышеперечисленных систем, проектирование и программная реализация подсистемы администрирования, вопросы социальной ответственности и ресурсоэффективности.In the company "Rubius" an asset management system "Rubius DrEAM" is being developed. In this system there is no subsystem of administration, as a result of which administration is performed manually with unnecessary expenditure of time and money.
The goal of the final qualification work is the development of the administration subsystem, which allows configuring the configuration and metadata necessary for the functioning of this asset management system.
The final qualification work examines the theoretical foundations of the above systems, design and software implementation of the administration subsystem, issues of social responsibility and resource efficiency
Experimental research of double-sided solar modules efficiency In the climatic conditions of central Kazakhstan
The article presents studies of double-sidedsolar modules in Kazakhstan. To conduct an experimental research of double-sided solar modules efficiency in the climatic conditions of Central Kazakhstan we have created an experimental solar power plant (SPP) located on the territory of Karaganda State Technical University. The solar power plant consists of four photovoltaic modules of KZ PV 270 M72 type and four photovoltaic modules of FSM-185D type. The rotary system was not used; solar panels are southward (directed to the south). The comparison was made with the solar power plantwithout orientation system which uses four photovoltaic modules of KZ PV 270 M72 type produced by Astana Solar LLP. The statistical analysis of information with an assessment of parameters of distribution and criteria for processing of results of scientific experiment is carried out. The correlation and regression analysis is performed. The least square method (coefficient calculation) is used in data processing. We have developed the computational model simulating the SPP by means of which the theoretical averaged values of energy amount generated in kWh/day have been obtained, and the actual values have been received by in-use measurements of SPP parameters within a year. The results of this work showed that the use of double-sided solar modules in Kazakhstan is very promising and can be a decisive factor for their widespread use with the tendency to lower prices
11Beta‐hydroxysteroid dehydrogenase‐1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis
Current clinical practice and outcome of neoadjuvant chemotherapy for early breast cancer: analysis of individual data from 94,638 patients treated in 55 breast cancer centers
Neoadjuvant chemotherapy (NACT) is frequently used in patients with early breast cancer. Randomized controlled trials have demonstrated similar survival after NACT or adjuvant chemotherapy (ACT). However, certain subtypes may benefit more when NACT contains regimes leading to high rates of pathologic complete response (pCR) rates. In this study we analyzed data using the OncoBox research from 94,638 patients treated in 55 breast cancer centers to describe the current clinical practice of and outcomes after NACT under routine conditions. These data were compared to patients treated with ACT. 40% of all patients received chemotherapy. The use of NACT increased over time from 5% in 2007 up to 17.3% in 2016. The proportion of patients receiving NACT varied by subtype. It was low in patients with HR-positive/HER2-negative breast cancer (5.8%). However, 31.8% of patients with triple-negative, 31.9% with HR-negative/HER2-positive, and 26.5% with HR-positive/HER2-positive breast cancer received NACT. The rates of pCR were higher in patients with HR-positive/HER2-positive, HR negative/HER2-positive and triple-negative tumors (36, 53 and 38%) compared to HR-positive/HER2-negative tumors (12%). PCR was achieved more often in HER2-positive and triple-negative tumors over time.
This is the largest study on use and effects of NACT in German breast cancer centers. It demonstrates the increased use of NACT based on recommendations in current clinical guidelines. An improvement of pCR was shown in particular in HER2-positive and triple-negative breast cancer, which is consistent with data from randomized controlled trails
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